Jian-Ying Zhou,Geoffrey P Dann,Chong Wee Liew et al.
Jian-Ying Zhou et al.
The pancreatic islets of Langerhans play a critical role in maintaining blood glucose homeostasis by secreting insulin and several other important peptide hormones. Impaired insulin secretion due to islet dysfunction is linked to the pathog...
Benjamin C Orsburn,Luke H Stockwin,Dianne L Newton
Benjamin C Orsburn
The response to extracellular stimuli often alters the phosphorylation state of plasma membrane- associated proteins. In this regard, generation of a comprehensive membrane phosphoproteome can significantly enhance signal transduction and d...
Proteomics to study the diversity and dynamics of proteasome complexes: from fundamentals to the clinic [0.03%]
利用蛋白质组学研究蛋白酶体复合物的多样性和动态变化：从基础到临床
Marie-Pierre Bousquet-Dubouch,Bertrand Fabre,Bernard Monsarrat et al.
Marie-Pierre Bousquet-Dubouch et al.
This article covers the latest contributions of proteomics to the structural and functional characterization of proteasomes and their associated proteins, but also to the detection of proteasomes as clinical biomarkers in diseases. Proteaso...
Neurochemical dementia diagnostics in Alzheimer's disease: where are we now and where are we going? [0.03%]
阿尔茨海默病的神经化学痴呆诊断：现状与未来方向何处去？
Piotr Lewczuk,Johannes Kornhuber
Piotr Lewczuk
Neurochemical dementia diagnostics (NDD) is a routine laboratory tool used in the diagnostic process for patients with neurodegenerative disorders, such as Alzheimer's disease. Currently, two groups of biomarkers analyzed in the cerebrospin...
Isabella Panfoli,Maurizio Bruschi,Silvia Ravera et al.
Isabella Panfoli et al.
Evaluation of: Di Girolamo F, Boschetti E, Chung MC, Guadagni F, Righetti PG. 'Proteomineering' or not? The debate on biomarker discovery in sera continues. J. Proteomics 74(5), 589-594 (2011). The combinatorial peptide ligand library in as...
Identification and evaluation of a panel of serum biomarkers for predicting response to thalidomide in multiple myeloma patients [0.03%]
识别并评估一组血清生物标志物以预测多发性骨髓瘤患者对沙利度胺的反应
Qian Xiong,Feng Ge
Qian Xiong
Evaluation of: Rajpal R, Dowling P, Meiller J et al. A novel panel of protein biomarkers for predicting response to thalidomide-based therapy in newly diagnosed multiple myeloma patients. Proteomics 11(8), 1391-1402 (2011). Predicting respo...
Celso A Reis,Diana Campos,Hugo Osório et al.
Celso A Reis et al.
Evaluation of: Pedersen JW, Blixt O, Bennett EP et al. Seromic profiling of colorectal cancer patients with novel glycopeptide microarray. Int. J. Cancer 128(8), 1860-1871 (2011). Autoantibodies to cancer-associated antigens hold promise as...
The identification of protein biomarkers for oxidative stress in Down syndrome [0.03%]
用于唐氏综合症氧化应激的蛋白质生物标志物鉴定
Marzia Perluigi,D Allan Butterfield
Marzia Perluigi
The SODyssey: superoxide dismutases from biochemistry, through proteomics, to oxidative stress, aging and nutraceuticals [0.03%]
超氧歧化酶研究之旅：从生化到蛋白质组学，再到氧化应激、衰老和营养补充剂
Angelo D&#x;Alessandro,Lello Zolla
Angelo D&#x;Alessandro
A total of 40 years have already passed since the pioneering work of McCord and Fridovich on erythrocuprein superoxide dismutase (SOD) activity. This modern scientific 'Odyssey' has been accompanied by a series of successes in the fields of...
Pufeng Du,Tingting Li,Xin Wang
Pufeng Du
In the last two decades, the number of the known protein sequences increased very rapidly. However, a knowledge of protein function only exists for a small portion of these sequences. Since the experimental approaches for determining protei...