Study suggests new topoisomerase inhibitors are capable of unsilencing dormant UBE3A in mouse neurons [0.03%]
研究发现新型拓扑异构酶抑制剂能够唤醒小鼠神经元中的休眠UBE3A基因
Andreas Hadjivasiliou
Andreas Hadjivasiliou
Peptide retention prediction in reversed-phase chromatography: proteomic applications [0.03%]
反相色谱中的肽保留预测：蛋白质组学应用
Oleg Krokhin
Oleg Krokhin
Cara Sutton
Cara Sutton
Agilent Technologies provides support to influential protein function researcher [0.03%]
安捷倫科技支持著名功能蛋白研究學者
Cara Sutton
Cara Sutton
Giulia Bernardini,Daniela Braconi,Paola Lusini et al.
Giulia Bernardini et al.
Neisseria meningitidis infection still remains a major life-threatening bacterial disease worldwide. The availability of bacterial genomic sequences generated a paradigm shift in microbiological and vaccines sciences, and post-genomics (com...
Intact proteome fractionation strategies compatible with mass spectrometry [0.03%]
与质谱相兼容的完整蛋白质组分离策略
Alan A Doucette,John C Tran,Mark J Wall et al.
Alan A Doucette et al.
Proteome fractionation refers to separation at the level of intact proteins. Proteome fractionation may precede sample digestion and subsequent peptide-level separation and detection (i.e., bottom-up mass spectrometry [MS]). For top-down MS...
Janine Mok,Xiaowei Zhu,Michael Snyder
Janine Mok
Protein phosphorylation continues to be regarded as one of the most important post-translational modifications found in eukaryotes and has been implicated in key roles in the development of a number of human diseases. In order to elucidate ...
Mass spectrometry-based functional proteomics of poly(ADP-ribose) polymerase-1 [0.03%]
基于质谱的多腺苷二磷酸核糖转移酶-1功能蛋白质组学研究
Emilie Pic,Jean-Philippe Gagné,Guy G Poirier
Emilie Pic
PARP-1 is an abundant nuclear protein that plays an essential role in the regulation of many genome integrity and chromatin-based processes, such as DNA repair, replication or transcriptional regulation. PARP-1 modulates the function of chr...