Searching for reliable premortem protein biomarkers for prion diseases: progress and challenges to date [0.03%]
寻找可靠的朊毒病尸前蛋白生物标志物：迄今为止的进展与挑战
Di Ma,Lingjun Li
Di Ma
Prion diseases are a unique family of fatal neurodegenerative diseases caused by abnormal folding of normal cellular prion proteins in the brain. Due to the high risk of prion disease transmission and the lack of effective treatment to cure...
Role of proteomics in biomarker discovery and psychiatric disorders: current status, potentials, limitations and future challenges [0.03%]
蛋白质组学在生物标志物发现及精神障碍中的作用：现状、潜力、局限性及其未来挑战
Suman Patel
Suman Patel
Proteomic approaches have advanced clinical research towards more reliable, sensitive and specific biological diagnostic markers for diseases. Mood disorders are most difficult to diagnose and very much prevalent in society; hence, their pr...
Isotopically labeled proteome as an internal standard for multiple reaction monitoring-based biomarker quantification [0.03%]
同位素标记蛋白质作为多重反应监测基于生物标志物量化内部标准品的研究
Andrei Turtoi,Vincent Castronovo
Andrei Turtoi
Multiple reaction monitoring is a mass spectrometry technology used to selectively identify and quantify a known molecule in a complex mixture. The technology has gained favor in proteomic applications, especially for biomarker quantificati...
Wenzhou Li,Vicki H Wysocki
Wenzhou Li
Electron transfer dissociation (ETD) is an alternative technique used in mass spectrometry-based proteomics experiments. Because it is newer, most of the protein identification algorithms for ETD are still a simple derivation of well-establ...
Newly defined toxic α-helical prion protein monomer: implications for other neurodegenerative diseases? [0.03%]
新定义的有毒α-螺旋朊蛋白单体：对其他神经退行性疾病的意义？
Corinne Lasmézas,Minghai Zhou
Corinne Lasmézas
Human mesenchymal stromal cell proteomics: contribution for identification of new markers and targets for medicine intervention [0.03%]
人基质干细胞蛋白质组学：为医学干预的新标志物和靶标的鉴定作出贡献
Vitor Marcel Faça
Vitor Marcel Faça
Mesenchymal stem or stromal cells (MSCs) have become of great interest for cell-based therapy owing to their roles in tissue repair and immune suppression. MSCs have the ability to differentiate into specialized tissues, including bone, car...
Monocyte/macrophage proteomics: recent findings and biomedical applications [0.03%]
单核细胞/巨噬细胞蛋白质组学：最近的研究成果及其在医学中的应用
Annalisa Castagna,Rita Polati,Alessandra Maria Bossi et al.
Annalisa Castagna et al.
Macrophages, originating from the migration and differentiation of circulating monocytes into virtually all tissues, are extremely flexible and plastic cells that play vital homeostatic roles, but also contribute to the pathophysiology of m...
Angiopoietin-like protein 4: health effects, modulating agents and structure-function relationships [0.03%]
血管生成素样蛋白4：健康影响、调节剂及结构功能关系
Charlotte Grootaert,Tom Van de Wiele,Willy Verstraete et al.
Charlotte Grootaert et al.
Angiopoietin-like protein 4 (ANGPTL4) has been identified as a multifunctional signal protein. It is produced by a variety of tissues, and is secreted into the bloodstream in glycosylated, oligomerized, native and cleaved isoforms to modula...
Alain J van Gool,Ronald C Hendrickson
Alain J van Gool
Cerebrospinal fluid (CSF) can be considered the most promising biosample for the discovery and analysis of biomarkers in neuroscience, an area of great medical need. CSF is a body fluid that surrounds the brain and provides a rich pool of b...
Biomarkers for cervical cancer screening: the role of p16(INK4a) to highlight transforming HPV infections [0.03%]
用于筛查宫颈癌的生物标志物：p16(INK4a)在识别致癌型HPV感染中的作用
Magnus von Knebel Doeberitz,Miriam Reuschenbach,Dietmar Schmidt et al.
Magnus von Knebel Doeberitz et al.
Biomarkers indicating the initiation of neoplastic transformation processes in human papillomavirus (HPV)-infected epithelial cells are moving into the focus of cancer prevention research, particularly for anogenital cancer, including cance...