Proteomic insights into the extracellular matrix: a focus on proteoforms and their implications in health and disease [0.03%]
蛋白质组学视角下的细胞外基质研究:focus于蛋白变体及其对健康和疾病的影响
Amanpreet Kaur Bains,Alexandra Naba
Amanpreet Kaur Bains
Introduction: The extracellular matrix (ECM) is a highly organized and dynamic network of proteins and glycosaminoglycans that provides critical structural, mechanical, and biochemical support to cells. The functions of t...
Protein biomarkers for subtyping breast cancer and implications for future research: a 2024 update [0.03%]
2024年乳腺癌亚型蛋白质生物标志物及对未来研究的影响的更新报告
Claudius Mueller,Justin B Davis,Virginia Espina
Claudius Mueller
Introduction: Breast cancer subtyping is used clinically for diagnosis, prognosis, and treatment decisions. Subtypes are categorized by cell of origin, histomorphology, gene expression signatures, hormone receptor status,...
Optimization of glycopeptide enrichment techniques for the identification of clinical biomarkers [0.03%]
甘肽富集技术的优化以识别临床生物标志物
Sherifdeen Onigbinde,Cristian D Gutierrez Reyes,Vishal Sandilya et al.
Sherifdeen Onigbinde et al.
Introduction: The identification and characterization of glycopeptides through LC-MS/MS and advanced enrichment techniques are crucial for advancing clinical glycoproteomics, significantly impacting the discovery of disea...
Eleven shades of PASEF [0.03%]
PASEF的十一级色彩
Marta L Mendes,Klara F Borrmann,Gunnar Dittmar
Marta L Mendes
Introduction: The introduction of trapped ion mobility spectrometry (TIMS) in combination with fast high-resolution time-of-flight (TOF) mass spectrometry to the proteomics field led to a jump in protein identifications a...
Understanding metabolic resistance strategy of clinically isolated antibiotic-resistant bacteria by proteomic approach [0.03%]
采用蛋白质组学方法分析临床分离耐药细菌的代谢耐药机制
Bo Peng,Hui Li,Xuanxian Peng
Bo Peng
Introduction: Understanding the metabolic regulatory mechanisms leading to antibacterial resistance is important to develop effective control measures. Ar...
Validating proteomic biomarkers in saliva: distinguishing between health and periodontal diseases [0.03%]
口腔唾液蛋白质组生物标志物的验证：健康与牙周病的区别
Büşra Yılmaz,Gülnur Emingil
Büşra Yılmaz
Introduction: Periodontitis is a chronic inflammatory disease characterized by progressive soft tissue and alveolar bone loss due to interactions between microbial dental plaque and the host response. Despite extensive re...
Sara Khorami-Sarvestani,Samir M Hanash,Johannes F Fahrmann et al.
Sara Khorami-Sarvestani et al.
Introduction: Glycosylation, the process of glycan synthesis and attachment to target molecules, is a crucial and common post-translational modification (PTM) in mammalian cells. It affects the protein's hydrophilicity, c...
Formation of the Canadian Artificial Intelligence and Mass Spectrometry for systems biology (CAN-AIMS) consortium [0.03%]
加拿大人工智能和生物质谱系统生物学联盟（CAN-AIMS）的建立
Jennifer Geddes-McAlister,Arnaud Droit
Jennifer Geddes-McAlister
Nandha Kumar Balasubramaniam,Scott Penberthy,David Fenyo et al.
Nandha Kumar Balasubramaniam et al.
Introduction: Biomarker discovery is increasingly moving from single omics to multiomics, as well as from multi-cell omics to single-cell omics. These transitions have increasingly adopted digital transformation technolog...
Cellular thermal shift assay: an approach to identify and assess protein target engagement [0.03%]
细胞热位移测定法：一种鉴定和评估蛋白质靶向结合的方法
Liying Zhang,Yuchuan Wang,Chang Zheng et al.
Liying Zhang et al.
Introduction: A comprehensive and global knowledge of protein target engagement is of vital importance for mechanistic studies and in drug development. Since its initial introduction, the cellular thermal shift assay (CET...