Two decades of advances in sequence-based prediction of MoRFs, disorder-to-order transitioning binding regions [0.03%]
基于序列的预测二十年：MoRFs和构象转换结合区域的进展
Jiangning Song,Lukasz Kurgan
Jiangning Song
Introduction: Molecular recognition features (MoRFs) are regions in protein sequences that undergo induced folding upon binding partner molecules. MoRFs are common in nature and can be predicted from sequences based on th...
Blood plasma proteomic markers of Alzheimer's disease, current status and application prospects [0.03%]
血浆蛋白质组学标记物在阿尔茨海默病中的应用现状及前景展望
Polina A Strelnikova,Natalia V Zakharova,Alexey S Kononikhin et al.
Polina A Strelnikova et al.
Introduction: Identifying early risks of developing Alzheimer's disease (AD) is a major challenge as the number of patients with AD steadily increases and requires innovative solutions. Current molecular diagnostic modali...
Yumi Kwon,James M Fulcher,Ljiljana Paša-Tolić et al.
Yumi Kwon et al.
Introduction: Spatial biology is an emerging interdisciplinary field facilitating biological discoveries through the use of spatial omics technologies. Recent advancements in spatial transcriptomics, spatial genomics (e.g...
Zachery R Gregorich
Zachery R Gregorich
The path to anti-vector vaccines: current advances and limitations in proteomics and bioinformatics [0.03%]
反向疫苗学之路：蛋白质组学和生物信息学的最新进展与局限性
Isidro Sobrino,Margarita Villar,José de la Fuente
Isidro Sobrino
Patient-responsive protein biomarkers for cartilage degeneration and repair identified in the infrapatellar fat pad [0.03%]
膝髌脂肪垫中鉴定出的软骨退变和修复相关的患者响应蛋白标志物
Kaj S Emanuel,Luojiao Huang,Mirella J J Haartmans et al.
Kaj S Emanuel et al.
Objectives: Cartilage defects (CDs) are regarded as early manifestation of osteoarthritis (OA). The infrapatellar fat pad (IPFP) is an important mediator in maintaining joint homeostasis, disease progression and tissue re...
Urine proteomics in cardiovascular disease: advances in biomarker discovery and clinical applications [0.03%]
心血管疾病中的尿液蛋白质组学：生物标志物发现和临床应用的进展
Xiaohong Song,Zhaoran Chen,Yuehong Zheng et al.
Xiaohong Song et al.
Introduction: Cardiovascular diseases (CVDs) are the leading causes of mortality and morbidity worldwide, making early diagnosis and effective treatment essential. As a promising and noninvasive research method, urine pro...
Identifying therapeutic strategies for triple-negative breast cancer via phosphoproteomics [0.03%]
通过磷酸蛋白质组学鉴定三阴性乳腺癌的治疗策略
Yuhan Sheng,Gordon Mills,Xuejiao Zhao
Yuhan Sheng
Introduction: Given the poor prognosis of patients with TNBC, it is urgent to identify new biomarkers and therapeutic targets to enable personalized treatment strategies and improve patient survival. Comprehensive insight...
Proteogenomic profiling of acute myeloid leukemia to identify therapeutic targets [0.03%]
急性髓系白血病的蛋白质基因组分析以确定治疗靶点
Heather C Murray,Jonathan Sillar,Maddison Chambers et al.
Heather C Murray et al.
Introduction: Acute myeloid leukemia (AML) is an aggressive and poor-prognosis blood cancer. Despite a low mutation burden compared to other cancers, AML is heterogenous and identifying robust therapeutic targets has been...
Proteomic profiling of oral squamous cell carcinoma tissues reveals altered immune-related proteins: implications for personalized therapy [0.03%]
口腔鳞状细胞癌组织的蛋白质谱分析发现与免疫相关的蛋白发生改变：对个性化治疗的意义
Akhina Palollathil,Sreeranjini Babu,Chandran S Abhinand et al.
Akhina Palollathil et al.
Objectives: Oral squamous cell carcinoma poses a substantial global health challenge marked by rising mortality rate. Recently, immunotherapy has shown promising results in cancer management by enhancing immune response. ...