The evolution of analytical techniques for multiplex analysis of protein biomarkers [0.03%]
蛋白质生物标志物多重分析的分析技术的发展演变
Hyeyoon Kim,David Ross Hall,Lorenz Nierves et al.
Hyeyoon Kim et al.
Introduction: The landscape of biomarker development has evolved with advanced analytical technologies, particularly affinity- and mass spectrometry-based techniques. These advancements have deepened our understanding of ...
The potential of proteomics for in-depth molecular investigations of progressive supranuclear palsy [0.03%]
蛋白质组学在进行性核上性麻痹分子深入研究中的潜力
Silvia Romero-Murillo,Seojin Lee,Joaquín Fernández-Irigoyen et al.
Silvia Romero-Murillo et al.
Introduction: Progressive supranuclear palsy (PSP) is a rare neurodegenerative disorder. The lack of comprehension about the pathogenesis of the disease, its heterogeneity, and the complex clinical evaluation in early sta...
Shaping the future of precision medicine: plasma proteomics to uncover insights in thrombosis [0.03%]
精准医疗的未来：运用血浆蛋白质组学揭示血栓的新见解
Emil Johansson,Maria Jesus Iglesias,Jacob Odeberg et al.
Emil Johansson et al.
Introduction: Advances in various proteomics technologies, especially high-throughput and reproducibility, have enabled the systematic exploration of the circulating thrombosis proteome. This includes dissecting biologica...
Extracellular vesicle proteomics in brain solid tumors: future strategy for personalized medicine [0.03%]
脑部实体肿瘤的细胞外囊泡蛋白质组学：精准医学未来策略
Sonia Spinelli,Andrea Garbarino,Marco Pavanello et al.
Sonia Spinelli et al.
Introduction: Brain solid tumors are a leading cause of cancer-related mortality at all ages. The updated 2021WHO Central Nervous System tumor classification is based on genomic diagnostics. Nonetheless, extracellular ves...
Optimization of bottom-up proteomic sample preparation by design of experiments for absolute quantification of 257 proteins in human plasma using UPLC-MRM-MS [0.03%]
基于实验设计优化底物蛋白质组样品制备以实现人血浆中257种蛋白的绝对定量分析-UPLC-MRM-MS法
Kari Arnarson,Kristrun Y Holm,Valdis Gunnarsdottir Thormar et al.
Kari Arnarson et al.
Introduction: Targeted protein absolute quantification using mass spectrometry holds promise for identifying biomarkers for diagnosis, prognosis, and personalized medicine. However, complex and time-consuming workflows, p...
Immobilized metal ion affinity chromatography: waltz of metal ions and biomacromolecules [0.03%]
金属离子亲和色谱：金属离子与生物大分子之舞
Rui Yan,Yan-Ming Xu,Andy T Y Lau
Rui Yan
Introduction: Immobilized metal ion affinity chromatography (IMAC) is an effective method developed in the 1980s for the separation and purification of proteins. The system consists of a solid-phase matrix, a linking liga...
Recent implementations of data-independent acquisition for cancer biomarker discovery in biological fluids [0.03%]
近期基于数据无关型采集的癌症生物标志物发现（应用于生物流体）
Annie Ha,Michael Woolman,Matthew Waas et al.
Annie Ha et al.
Introduction: Cancer is the second leading cause of death worldwide and accurate biomarkers for early detection and disease monitoring are needed to improve outcomes. Biological fluids, such as blood and urine, are ideal ...
Utilization of high-resolution mass spectrometry and data-independent analysis to track the monoclonal antibody spatial stability [0.03%]
利用高分辨率质谱和数据非依赖性分析追踪单克隆抗体的稳定性分布
Valerie Prochazkova,Michal Rosulek,Michael Karpisek et al.
Valerie Prochazkova et al.
Objectives: Chemical cross-linking coupled with mass spectrometry (CXMS) offers the distance constraints critical for building the structural model of protein and protein complexes and understanding dynamics of biological...
Unravelling disease complexity: integrative analysis of multi-omic data in clinical research [0.03%]
解开疾病复杂性：临床研究中多组学数据的综合分析
Ornella Cominetti,Loïc Dayon
Ornella Cominetti
Introduction: A holistic view on biological systems is today a reality with the application of multi-omic technologies. These technologies allow the profiling of genome, epigenome, transcriptome, proteome, metabolome as w...
Acoustic ejection Mass spectrometry: the potential for personalized medicine [0.03%]
声射流质量测量技术在精准医疗中的应用潜力
Chang Liu
Chang Liu
Introduction: The emergence of personalized medicine (PM) has shifted the focus of healthcare from the traditional 'one-size-fits-all' approach to strategies tailored to individual patients, accounting for genetic, enviro...