Tobias Meisinger,Amelie Vogt,Robin Kretz et al.
Tobias Meisinger et al.
Introduction: Ligand binding assays combining immunoaffinity enrichment steps with mass spectrometry (MS) readout have gained attention as a highly specific and sensitive tool for protein quantification. These techniques ...
Omics and rare diseases: challenges, applications, and future perspectives [0.03%]
组学与罕见病：挑战、应用及未来展望
Daniela Braconi,Haidara Nadwa,Giulia Bernardini et al.
Daniela Braconi et al.
Introduction: Rare diseases (RDs) are a heterogeneous group of diseases recognized as a relevant global health priority but posing aspects of complexity such as: geographical scattering of affected individuals, improper/l...
Metabolomics Studies in Cushing's Syndrome: Recent Developments and Perspectives [0.03%]
库欣综合征代谢组学研究的新进展及展望
Sowrabha Bhat,Vanya Kadla Narayana,T S Keshava Prasad
Sowrabha Bhat
Introduction: Exogenous Cushing's syndrome is the result of long-term exposure to glucocorticoids, while endogenous Cushing's syndrome occurs due to excessive production of glucocorticoids within the body. Cushing's syndr...
T cell population size control by coronin 1 uncovered: from a spot identified by two-dimensional gel electrophoresis to quantitative proteomics [0.03%]
经二维电泳发现的CORONIN 1调控T细胞群体大小：从点到定量蛋白质组学
Tohnyui Fabrice Ndinyanka,Katarzyna Buczak,Alexander Schmidt et al.
Tohnyui Fabrice Ndinyanka et al.
Introduction: Recent work identified members of the evolutionarily conserved coronin protein family as key regulators of cell population size. This work originated ~25 years ago through the identification, by two-dimensio...
AlphaFold and what is next: bridging functional, systems and structural biology [0.03%]
AlphaFold及未来展望——架起功能、系统与结构生物学之间的桥梁
Kacper Szczepski,Lukasz Jaremko
Kacper Szczepski
Introduction: The DeepMind's AlphaFold (AF) has revolutionized biomedical research by providing both experts and non-experts with an invaluable tool for predicting protein structures. However, while AF is highly effective...
Oncoproteins E6/E7 of the human papillomavirus types 16 & 18 synergize in modulating oncogenes and tumor suppressor proteins in colorectal cancer [0.03%]
人乳头瘤病毒16/18型癌蛋白E6/E7在结直肠癌中协同调节癌基因和抑癌蛋白
Queenie Fernandes,Lubna Therachiyil,Shahd M Younis et al.
Queenie Fernandes et al.
Objective: Our study presents a novel analysis of the oncogenes and tumor suppressor proteins directly modulated by E6/E7 of high-risk HPV types 16 and 18, in colorectal cancer (CRC). ...
Interaction and regulation of the mitochondrial proteome - in health and disease [0.03%]
线粒体蛋白质组的相互作用和调节：健康与疾病中的作用
Johan Palmfeldt
Johan Palmfeldt
Introduction: Mitochondria contain multiple pathways including energy metabolism and several signaling and synthetic pathways. Mitochondrial proteomics is highly valuable for studying diseases including inherited metaboli...
Two decades of advances in sequence-based prediction of MoRFs, disorder-to-order transitioning binding regions [0.03%]
基于序列的预测二十年：MoRFs和构象转换结合区域的进展
Jiangning Song,Lukasz Kurgan
Jiangning Song
Introduction: Molecular recognition features (MoRFs) are regions in protein sequences that undergo induced folding upon binding partner molecules. MoRFs are common in nature and can be predicted from sequences based on th...
Blood plasma proteomic markers of Alzheimer's disease, current status and application prospects [0.03%]
血浆蛋白质组学标记物在阿尔茨海默病中的应用现状及前景展望
Polina A Strelnikova,Natalia V Zakharova,Alexey S Kononikhin et al.
Polina A Strelnikova et al.
Introduction: Identifying early risks of developing Alzheimer's disease (AD) is a major challenge as the number of patients with AD steadily increases and requires innovative solutions. Current molecular diagnostic modali...
Yumi Kwon,James M Fulcher,Ljiljana Paša-Tolić et al.
Yumi Kwon et al.
Introduction: Spatial biology is an emerging interdisciplinary field facilitating biological discoveries through the use of spatial omics technologies. Recent advancements in spatial transcriptomics, spatial genomics (e.g...