MRMAssayDB: a comprehensive integrated resource for targeted proteomics assays [0.03%]
MRMAssayDB：靶向蛋白质组定量的全面资源库
Yassene Mohammed,Pallab Bhowmick,Christoph H Borchers
Yassene Mohammed
Introduction: Targeted quantitative proteomics is vital for accurate protein measurement in biological samples. Techniques like Multiple Reaction Monitoring (MRM or SRM) and Parallel Reaction Monitoring (PRM), often used ...
A 2025 perspective on the role of machine learning for biomarker discovery in clinical proteomics [0.03%]
从临床蛋白质组学生物标志物发现角度看机器学习的作用(至2025年)
Charlotte Adams,Wout Bittremieux
Charlotte Adams
Introduction: Machine learning holds significant promise for accelerating biomarker discovery in clinical proteomics, yet its real-world impact remains limited by widespread methodological pitfalls and unrealistic expecta...
Amal Mohamed Kamal,Amy Carfagno,Cynthia Nagy et al.
Amal Mohamed Kamal et al.
Introduction: The investigation of different proteoforms in clinical samples is a promising approach to elucidate the molecular mechanisms of diseases. Furthermore, proteoform analysis holds great potential for identifyin...
Proteomic profiling of cerebrospinal fluid reveals pathophysiology changes and diversity of treatment response in pediatric streptococcus pneumoniae meningitis [0.03%]
脑脊液蛋白质组分析揭示了儿童肺炎链球菌脑膜炎的病理生理变化和治疗反应的多样性
Jing Wei,Binglin Jian,Liang Zhu et al.
Jing Wei et al.
Background: Streptococcus pneumoniae meningitis (SPM) is a critical pediatric infection with a high mortality rate. This study aimed to investigate changes in the cerebrospinal fluid (CSF) proteome in SPM patients and ide...
HDL proteome: from its characterization to quantitative measurements in particle subspecies and functional associations [0.03%]
从颗粒亚型的表征到定量测量及其功能关联的HDL蛋白组学研究
Tomáš Vaisar,Graziella Eliza Ronsein
Tomáš Vaisar
Introduction: Recent failures of therapeutic interventions aimed at elevating high-density lipoprotein cholesterol (HDL-C) have renewed the need to reconceptualize HDL. The HDL proteome constitutes over 50% of the HDL mas...
Repurposing proteomic nanolc-ms platforms for untargeted metabolomics: evaluating dia and polarity switching performance in human plasma [0.03%]
蛋白质组纳米LC-MS平台的再利用：在人血浆中评估DIA和极性转换性能用于非靶向代谢组学研究
Frederico G Pinto,Alexander D Giddey,Nesrin Mohamed et al.
Frederico G Pinto et al.
Background: Many of the advanced MS methods applied in proteomics such as nanoflow LC-MS with data-independent acquisition have yet to be verified and/or optimized on metabolomics applications. ...
Mapping of volatile organic compounds in children's saliva using headspace sorbent extraction coupled to TD-GC-MS [0.03%]
采用顶空吸附萃取结合热脱附气相色谱-质谱法绘制儿童唾液中挥发性有机物图谱
Efstathios A Elia,Anna Zissimou,Photini Papaioakeim et al.
Efstathios A Elia et al.
Objectives: Saliva, an easily accessible biofluid, has emerged as a promising source of biomarkers for noninvasive disease diagnostics. Human saliva comprises a complex mixture of volatile organic compounds (VOCs) origina...
Proteomic technologies for profiling cell-membrane/secretome interactions in brain metastatic cancer progression [0.03%]
脑转移性癌症进展中用于检测细胞膜/分泌组相互作用的蛋白质组学技术
Iulia M Lazar
Iulia M Lazar
Introduction: . The ability of cancer cells to disseminate from the primary tumor and form metastatic lesions frequently leads to fatal outcomes. Recently, however, it has been recognized that this process is driven by co...
Proteomic blood-biomarkers for personalized risk stratification of diabetic retinopathy patients [0.03%]
糖尿病视网膜病变患者个性化风险分层的蛋白组学血液生物标志物
Bent Honoré,Lasse Jørgensen Cehofski,Steffen Heegaard et al.
Bent Honoré et al.
Introduction: Diabetes mellitus (DM) is a challenging chronic disease worldwide. The incidence is expected to rise dramatically by 2030 due to smoking, obesity and aging population. This increases public health burden in ...