Owen F J Hovey,Gilles A Lajoie,Tyler T Cooper
Owen F J Hovey
Introduction: Middle-down proteomics (MDP) bridges bottom-up and top-down proteomics, analyzing 3-10 kDa peptides to enhance sequence coverage and post-translational modification (PTM) localization. This approach is cruci...
Future of clinical proteomics: could targeted multi-protein panels supplant low-throughput methods? [0.03%]
临床蛋白质组学的未来：能否用靶向型多蛋白谱系替代低通量方法？
Poornima Ramesh,Thottethodi Subrahmanya Keshava Prasad
Poornima Ramesh
Introduction: Mass spectrometry (MS)-based proteomics, especially the targeted applications, hold great potential as Laboratory Developed Tests (LDTs) for clinical applications. They are suitable for widespread clinical u...
Mass spectrometry (MS)-based proteomics and the sulfome: clinical potential [0.03%]
基于质谱(MS)的蛋白质组学与硫醇组：临床应用潜力
Sally O Oswald,Leonard A Daly,Shahram Mesdaghi et al.
Sally O Oswald et al.
Introduction: Protein tyrosine sulfation is of growing scientific interest due to its biological and clinical significance, yet it remains an underexplored post-translational modification (PTM). Catalyzed by Golgi-localiz...
An interview with William Cho [0.03%]
对威廉赵的访谈
William C Cho
William C Cho
Discovery and targeted Mass spectrometry-based proteomics of Ovarian cancer [0.03%]
卵巢癌的发现及基于质谱法的蛋白质组学分析
Nicole E Platzer,Amanda B Hummon
Nicole E Platzer
Introduction: Ovarian cancer is the most lethal gynecologic malignancy and has seen little progress in early detection and treatment. Mass spectrometry-based proteomics is a powerful technique that can be used to understa...
Integrative analysis of proteomic and mri data reveals protein associations with brain imaging features in Alzheimer's disease [0.03%]
整合蛋白质组学和MRI数据揭示阿尔茨海默病的蛋白质与脑影像表型关联
Sotiroula Afxenti,Marilena M Bourdakou,Eleni M Loizidou et al.
Sotiroula Afxenti et al.
Background: Alzheimer's disease (AD) is a progressive neurodegenerative disorder and the leading cause of dementia worldwide. Despite extensive research, the complex molecular mechanisms underlying AD remain incompletely ...
Toward real clinical utility: leveraging comprehensive proteomic datasets for clinical insight [0.03%]
面向真正的临床实用性：利用全面的蛋白质组数据集进行临床洞察
Karin D Rodland,Bing Zhang
Karin D Rodland
Introduction: Recent advances in multi-omic technologies and computational tools have enabled comprehensive studies of cancer that integrate proteomics, genomics, transcriptomics, and metabolomics to improve disease under...
Contribution of metaproteomics to unveiling the functional role of the gut microbiome in human physiology and metabolism [0.03%]
代谢组学在揭示肠道微生物组在人体生理和新陈代谢中的功能作用方面的贡献
Alessandro Tanca,Sergio Uzzau
Alessandro Tanca
Introduction: The human gut microbiome (HGM) profoundly influences human physiology. In recent years, it has become clearer that a healthy HGM is much better defined by its functional profile than by its taxonomic composi...
Salwa Alshehri,Rui Vitorino,Ohud Saleh et al.
Salwa Alshehri et al.
Introduction: Clinical proteomics has become a pivotal component of precision medicine, significantly advancing the understanding of disease mechanisms and informing therapeutic strategies. This review explores how clinic...