Bioinformatics approaches in the discovery and understanding of reproduction-related biomarkers [0.03%]
生物信息学方法在生殖相关生物标志物发现及作用机制阐释中的应用研究进展
Athanasios K Anagnostopoulos,Georgia Tsiliki,George Spyrou et al.
Athanasios K Anagnostopoulos et al.
The emerging field of bioinformatics in proteomics is introducing new algorithms in order to handle large and heterogeneous datasets and improve the knowledge-discovery process. Management systems, software construction and application, dat...
Proteomic analysis of amniotic fluid for the diagnosis of fetal aneuploidies [0.03%]
羊水蛋白质组分析在胎儿染色体非整倍体诊断中的应用研究
Aggeliki Kolialexi,Georgia Tounta,Ariadni Mavrou et al.
Aggeliki Kolialexi et al.
Advances in technologies associated with mass spectrometry-based proteomic techniques have added a new dimension to the field of biomedical research. Most of the existing research on human gestation has focused on the application of these h...
Enrique Calvo,Emilio Camafeita,Benjamín Fernández-Gutiérrez et al.
Enrique Calvo et al.
Selected reaction monitoring (SRM) is a highly selective and sensitive mass spectrometric methodology for precise and accurate quantification of low-abundant proteins in complex mixtures and for characterization of modified peptides, and co...
Jason D Hoffert,Trairak Pisitkun,Mark A Knepper
Jason D Hoffert
Protein phosphorylation plays a critical role in the signaling pathways regulating water and solute transport in the distal renal tubule (i.e., renal collecting duct). A central mediator in this process is the antidiuretic peptide hormone a...
Proteomic analysis and in vitro developmental toxicity tests for mechanism-based safety evaluation of chemicals [0.03%]
基于机制的化学品安全评价的蛋白质组分析及体外发育毒性试验
Makoto Usami,Katsuyoshi Mitsunaga
Makoto Usami
Mechanism-based safety evaluation and reduction of animal use are important issues in recent developmental toxicology. In vitro developmental toxicity tests with proteomic analysis are the most promising solution to these issues. Groebe et ...
Juergen Kast
Juergen Kast
The regulation of protein abundance by microRNA (miRNA)-mediated repression of mRNA translation is a rapidly growing area of interest in biochemical research. In animal cells, the miRNA seed sequence does not perfectly match that of the mRN...
Proteomics research in breast cancer: balancing discovery and hypothesis-driven studies [0.03%]
乳腺癌蛋白质组学研究：探索与假设驱动型研究并重
Timothy D Veenstra
Timothy D Veenstra
Profiling for novel proteomics biomarkers in neurodevelopmental disorders [0.03%]
神经发育障碍的新蛋白质组生物标志物的特征分析
Ed Dudley,Frank Hässler,Johannes Thome
Ed Dudley
Protein biomarker discovery from biological fluids, such as serum, has been widely applied to disorders such as cancer and has more recently also been utilized in neuro-psychiatric disorders with relatively clear biological causes, such as ...
Proteomic approaches to understanding the role of the cytoskeleton in host-defense mechanisms [0.03%]
运用蛋白质组学方法研究细胞骨架在宿主防御机制中的作用
Marko Radulovic,Jasminka Godovac-Zimmermann
Marko Radulovic
The cytoskeleton is a cellular scaffolding system whose functions include maintenance of cellular shape, enabling cellular migration, division, intracellular transport, signaling and membrane organization. In addition, in immune cells, the ...
Gianfranco Mamone,Gianluca Picariello,Francesco Addeo et al.
Gianfranco Mamone et al.
Owing to its extensive use in the human diet, wheat is among the most common causes of food-related allergies and intolerances. Allergies to wheat are provoked by ingestion, inhalation or contact with either the soluble or the insoluble glu...