Arnoud J Groen,Kathryn S Lilley
Arnoud J Groen
Membrane proteins are key molecules in the cell and are important targets for drug development. Much effort has, therefore, been directed towards research of this group of proteins, but their hydrophobic nature can make working with them ch...
Lipid raft proteome reveals that oxidative phosphorylation system is associated with the plasma membrane [0.03%]
脂筏蛋白组学表明氧化磷酸化系统与质膜相关
Bong-Woo Kim,Chang Seok Lee,Jae-Sung Yi et al.
Bong-Woo Kim et al.
Although accumulating proteomic analyses have supported the fact that mitochondrial oxidative phosphorylation (OXPHOS) complexes are localized in lipid rafts, which mediate cell signaling, immune response and host-pathogen interactions, the...
The proteome of sickle cell disease: insights from exploratory proteomic profiling [0.03%]
镰状细胞疾病的蛋白质组:来自探索性蛋白质组学分析的见解
Susan Yuditskaya,Anthony F Suffredini,Gregory J Kato
Susan Yuditskaya
The expanding realm of exploratory proteomics has added a unique dimension to the study of the complex pathophysiology involved in sickle cell disease. A review of proteomic studies published on sickle cell erythrocytes and plasma shows tre...
Venous and arterial endothelial proteomics: mining for markers and mechanisms of endothelial diversity [0.03%]
血管和动脉内皮蛋白质组学：挖掘内皮多样性的标志物和机制
Matthew R Richardson,Xianyin Lai,Frank A Witzmann et al.
Matthew R Richardson et al.
Endothelial cells (ECs) line the inside of arterial and venous blood vessels in a continuous monolayer and have the important function of responding to environmental cues to regulate vascular tone and new blood vessel formation. They also h...
PI3K-based molecular signatures link high PI3K pathway activity with low ER levels in ER+ breast cancer [0.03%]
基于PI3K的分子特征连接了ER阳性乳腺癌中的高PI3K通路活性和低ER水平
Alex Sanchez,Josep Villanueva
Alex Sanchez
Resistance to endocrine therapy is a major clinical problem in estrogen receptor (ER)(+) breast cancer. Endocrine resistance can be caused by multiple mechanisms but unfortunately is not fully understood. The work reported by Creighton et a...
Mehdi Mesri,Christopher Kinsinger,Emily Boja et al.
Mehdi Mesri et al.
The 3rd annual 'Cancer Proteomics Conference', organized by Select Biosciences (Sudbury, UK), was held in Berlin, Germany, 8-9 June 2010. With the aim of strengthening the links between scientists from Europe, as well as international inves...
Highlights from the 2010 BAS/BSCR spring meeting: New Frontiers in Cardiovascular Research [0.03%]
2010年BAS/BSCR春季会议亮点——心血管研究的新领域
Mélanie Abonnenc,Christin Stegemann,Manuel Mayr
Mélanie Abonnenc
The British Atherosclerosis Society (BAS)/British Society for Cardiovascular Research (BSCR) spring meeting was held in Manchester, UK, on 7-8 June 2010. Experts in the field of systems biology, proteomics, metabolomics and miRNAs presented...
The extracellular matrix: an underexplored but important proteome [0.03%]
细胞外基质：一个尚未被深入探索但十分重要的蛋白质组学领域
Richard Wilson
Richard Wilson
Wei Wang,Lantu Gou,Jinliang Yang
Wei Wang
Verena Prokosch,Carolin Chiwitt,Karin Rose et al.
Verena Prokosch et al.
Neurons of the mammalian CNS, including retinal ganglion cells, lack, in contrast to the PNS, the ability to regenerate axons spontaneously after injury. Regeneration of the CNS is extremely complex and involves various molecular factors an...