Clinical utility of blood-based biomarkers in pregnant women with inflammatory bowel disease [0.03%]
血基生物标志物在炎症性肠病孕妇中的临床应用价值
Hannah J Holstein,Dianne G Bouwknegt,Sanne J Gordijn et al.
Hannah J Holstein et al.
Introduction: Pregnancy in women with inflammatory bowel disease (IBD) is common, and active disease remains a key driver of adverse maternal and fetal outcomes. Maintaining remission throughout pregnancy is therefore ess...
What is the future of nanoparticles as a clinical theranostic tool for glioblastoma? [0.03%]
纳米颗粒在未来胶质母细胞瘤临床治疗中的应用展望
Maxim Shevtsov,Viacheslav Fedorov,Natalia Yudintceva et al.
Maxim Shevtsov et al.
Introduction: Despite a combined approach to manage malignant brain tumors (including glioblastoma), which includes surgical removal of the tumor followed by cycles of radiotherapy and chemotherapy, patient survival remai...
CRISPR-Cas system: recent advancements in prompt diagnosis of high-risk HPV genotypes in cervical cancer [0.03%]
CRISPR-Cas系统在宫颈癌高危HPV基因型快速诊断中的最新进展
Pushpendra Singh,Kuldeep Sharma,Vaibhav K Tamrakar et al.
Pushpendra Singh et al.
Introduction: The CRISPR/Cas system has emerged as a highly versatile platform for diagnosing infectious diseases, particularly viral pathogens. Human papillomavirus (HPV) comprises of more than 200 types, with persistent...
Translation of scRNA-seq to a clinical blood test for infection diagnostics [0.03%]
用于感染诊断的scRNA-seq血液检测翻译技术
Nelson L S Tang,Tsz-Ki Kwan,Jinghan Huang et al.
Nelson L S Tang et al.
Introduction: Early and accurate triage of patients with febrile illness is crucial for appropriate treatment. While standard inflammatory biomarkers are often nonspecific, transcriptome analysis of peripheral blood has d...
Bringing liquid biopsy to the clinic: diagnostic utility of circulating tumor cells, circulating tumor DNA, and extracellular vesicles in personalized cancer care [0.03%]
液体活检的临床应用：循环肿瘤细胞、循环肿瘤DNA和胞外囊泡在个性化癌症诊疗中的诊断作用
Nivedita N Kaorey,Julia V Burnier
Nivedita N Kaorey
Prognostic value of dynamic sST2 and immune-coagulation biomarkers in severe community-acquired pneumonia: insights from a prospective cohort study [0.03%]
动态sST2和免疫-凝血标志物在严重社区获得性肺炎预后中的价值：一项前瞻性队列研究的启示
Shanshan Liu,Jian Dong,Jia Hao Wu
Shanshan Liu
Background: Effective risk stratification in community-acquired pneumonia (CAP) remains challenging. We evaluated soluble suppression of tumorigenicity 2 (sST2) dynamics for predicting 90-day all-cause mortality and hospi...
Artificial intelligence in cancer screening: a narrative review of current evidence and future directions [0.03%]
人工智能在癌症筛查中的应用：现有证据及未来方向的叙述性回顾
Yigit Yazarkan,Gamze Sonmez,Taha Koray Sahin et al.
Yigit Yazarkan et al.
Introduction: Cancer remains one of the leading causes of death worldwide, with outcomes improving significantly when the disease is detected at an early stage. Screening programs have demonstrated clear benefits, yet the...
Challenges facing genetic diagnostics of Huntington's disease: an update [0.03%]
亨廷顿舞蹈病基因诊断面临的挑战：最新研究进展
Larissa Arning,Carsten Saft,Huu Phuc Nguyen
Larissa Arning
Introduction: Since 1993, when a polymorphic CAG trinucleotide repeat was established as the cause of Huntington's disease (HD), fragment analysis has been the first-tier test in genetic diagnosis of HD. However, in recen...
Beyond the laboratory: how COVID-19 reshaped specimen collection, testing workflows, and diagnostic algorithms [0.03%]
疫情之下检验医学的发展与挑战：样本采集、实验室检测流程和诊断算法改变了吗？
Alexander Domnich,Elena Pariani
Alexander Domnich
Introduction: The SARS-CoV-2 pandemic forced a radical expansion of essential public health laboratory services that went beyond basic testing. This perspective highlights key shifts in laboratory function, specifically t...
Advances in ovarian cancer screening and early detection: from biomarkers to multivariate Index Assays [0.03%]
卵巢癌筛查和早期检测的新进展：从中标志物到多元指数检测法
Carlos Salomon,Melissa Razo-Azamar,Aleksandra Gentry-Maharaj et al.
Carlos Salomon et al.
Introduction: Ovarian cancer remains one of the leading causes of cancer-related death in women, largely due to nonspecific symptoms and late-stage diagnosis. Improving outcomes through early detection, both earlier diagn...