Molecular insights into the gut-thyroid Axis: microbiota-driven biomarkers and diagnostic applications [0.03%]
Zoran Gluvić,Sonja Zafirović,Emina Sudar-Milovanović et al.
Zoran Gluvić et al.
Introduction: New research has shown an intriguing link between the gut bacteria and the thyroid. A gut-thyroid relationship affects energy production, immunological function, and inflammation. As a result, disrupted gut ...
Role of oral microbiome in modulating immune response in oral cancer development. a systematic review [0.03%]
口腔微生物组在调节口腔癌免疫反应中的作用：系统性综述
Rezhat Abbas,Nazifa Javaid
Rezhat Abbas
Background: Oral squamous cell carcinoma, the most common head and neck cancer, is characterized by aggressive invasion, frequent lymph node metastasis, and high recurrence. ...
Liquid biopsy in meningioma: a meta-analysis of diagnostic accuracy across fluid-based biomarkers [0.03%]
基于液体活检的脑膜瘤诊断meta分析研究
Yasminn Meireles,Carlos Pilotto Heming,Veronica Aran
Yasminn Meireles
Background: This systematic review and meta-analysis of diagnostic test accuracy evaluated the performance of noninvasive liquid biopsy methods for diagnosis of meningioma, the most common primary intracranial neoplasm in...
Exploring non-sputum biosignatures for tuberculosis triage and diagnosis in children living with hiv [0.03%]
探索非咳痰生物标志物在HIV阳性儿童结核病分诊和诊断中的应用
Peter J Kitonsa,Devan Jaganath
Peter J Kitonsa
Introduction: Pediatric tuberculosis (TB), especially among children co-infected with HIV, remains a significant global health challenge. Traditional sputum-based diagnostics are less effective in this population due to d...
Guarding the genome: strategies for off-target detection and minimization in CRISPR/Cas9 system [0.03%]
护卫基因组：CRISPR/Cas9系统中的脱靶效应检测与最小化策略
Malihe Lotfi,Zahra Farshchian Yazdi,Mohammad Reza Hashemi et al.
Malihe Lotfi et al.
Introduction: CRISPR-based genome editing has revolutionized molecular diagnostics and therapeutic applications, offering precise genetic modifications. However, off-target effects remain a significant challenge, potentia...
Emmanuel J Favaloro,Gary W Moore,Leonardo Pasalic
Emmanuel J Favaloro
Harnessing host-derived biomarkers for personalized diagnosis of invasive fungal infections [0.03%]
利用宿主衍生生物标志物进行侵袭性真菌感染的个性化诊断
Jennifer Scott,Ana Machado,Agostinho Carvalho et al.
Jennifer Scott et al.
Introduction: Invasive fungal infections (IFIs) remain a major clinical challenge due to the expansion of high-risk patient groups and drawbacks of conventional diagnostics which contribute to the devastating mortality ra...
Jan Trøst Jørgensen,Kristian Egebjerg
Jan Trøst Jørgensen
Introduction: HER2-targeted antibody-drug conjugates (ADCs) have shown promising outcomes in the treatment of patients with various HER2-expressing solid tumors. The efficacy of ADCs is influenced by several factors, such...
ESR1 ctDNA testing: literature review and comparison of assays for ESR1 mutation detection in advanced hormone receptor-positive breast cancer [0.03%]
用于检测晚期激素受体阳性乳腺癌中ESR1突变的ctDNA检测方法比较及文献回顾
Alexander Yarunin,Hanna Ahlgren,Moumita Chaki et al.
Alexander Yarunin et al.
Introduction: Aromatase inhibitors (AI) plus CDK4/6 inhibitors are the current first-line standard-of-care for hormone receptor (HR)-positive/HER2-negative advanced breast cancer (ABC). However, mutations in ESR1 (ESR1m),...
Digital Pathology and ai: enhancing molecular diagnostics in low- and middle-income countries [0.03%]
数字化病理和人工智能：增强低收入和中等收入国家的分子诊断能力
Arman Rahman,Chee Leong Cheng,Reza Salim et al.
Arman Rahman et al.
Introduction: Molecular diagnostics in Low- and Middle-Income Countries (LMICs) face significant barriers: limited expertise, geographical access, and infrastructure. These impede effective disease management and public h...