AI and the digital pathology revolution: clinical applications in cancer diagnosis and assessment [0.03%]
人工智能与数字病理学革命：癌症诊断与评估的临床应用
Somnath Paul,H Michael Isaacs,Richard J Cote
Somnath Paul
Introduction: Hematoxylin & Eosin (H&E) stained slides are the gold standard for cancer diagnosis but are subject to labor-intensive review and inter-observer variability. Whole-slide imaging (WSI) and digital pathology a...
Evaluation of cell free DNA methylation as a biomarker to differentiate different liver diseases [0.03%]
评估游离细胞DNA甲基化作为区分不同肝病生物标志物的价值
Jing Zuo,Xin-Hua Guo,Hang-Yu Ma et al.
Jing Zuo et al.
Introduction: A major challenge in many liver diseases is the lack of highly sensitive, specific, and minimally invasive biomarkers. Cell-free DNA (cfDNA) methylation compensates for the limitations of existing biomarkers...
Bio-interfaces-based detection of gastric carcinogenic bacterium Helicobacter pylori: enabling early and high precision diagnosis [0.03%]
基于生物界面的胃癌致病菌幽门螺旋杆菌检测：实现早期和高精度诊断
Akshita Singla,Utkarsh Jain,Nidhi Chauhan
Akshita Singla
Introduction: Helicobacter pylori (H. pylori) infection is widespread globally, affecting more than half of the world's population. However, traditional detection methods, which have been used for decades, have several li...
LncRNA HAR1A in triple-negative breast cancer: mechanisms and the role of polymorphism rs 6089838 in susceptibility [0.03%]
长链非编码RNA HAR1A在三阴性乳腺癌中的作用机制及其多态性rs 6089838的作用
Xiaobing Yi,Lina Huang,Linna Kong et al.
Xiaobing Yi et al.
Background: Long non-coding RNAs (lncRNAs) are increasingly recognized as crucial regulators and potential biomarkers in triple-negative breast cancer (TNBC). This study examined the link between the rs6089838 polymorphis...
Advances in molecular diagnostic strategies during the SARS-CoV-2 pandemic [0.03%]
新型冠状病毒肺炎疫情期间分子诊断策略的发展趋势
Sushil Kumar Shukla,Amit Singh,Ramakant Yadav et al.
Sushil Kumar Shukla et al.
Introduction: The SARS-CoV-2 pandemic provided critical insights into pandemic preparedness. The community spread can be slowed down or contained through effective, rapid, and robust diagnosis of infected individuals. ...
Beyond mutations: epigenetic and fragmentomic landscapes of cfDNA in lung cancer [0.03%]
超越突变：肺癌液体活检中ctDNA的表观遗传及片段组学特性
Jing Liu,Laura S E Schulz,Qing Zhou
Jing Liu
Introduction: Lung cancer is the most frequently diagnosed cancer worldwide and the leading cause of cancer-related mortality. Cell-free DNA (cfDNA) has emerged as a powerful biomarker in cancer detection. Early diagnosti...
Cell-free HPV DNA as a complementary biomarker to imaging in HPV-associated oropharyngeal squamous cell carcinoma: a narrative synthesis of key studies [0.03%]
人乳头瘤病毒相关口腔扁平苔藓鳞状细胞癌影像学检查的互补生物标志物：无细胞HPV DNA叙事综合研究的关键发现
Ingeborg Tinhofer,Franziska Hausmann
Ingeborg Tinhofer
Introduction: Human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma (OPSCC) represents a biologically distinct disease entity with superior prognosis compared with HPV-negative head and neck cancers....
Association between the uric acid-to-HDL-cholesterol ratio and diabetic kidney disease in individuals with type 2 diabetes and NAFLD: evidence from NHANES and an external hospital cohort [0.03%]
基于NHANES和医院队列的证据，2型糖尿病伴NAFLD人群中尿酸与HDL-C比值与糖尿病肾病的关系
Zhaoxin Gong,Dingding Zhang,Nan Cai et al.
Zhaoxin Gong et al.
Background: Diabetic kidney disease (DKD) is a major microvascular complication of type 2 diabetes mellitus (T2DM). Nonalcoholic fatty liver disease (NAFLD) frequently coexists with T2DM and may increase metabolic and ren...
Alpha-synuclein seed amplification assays differentiate synucleinopathies [0.03%]
α-突触核蛋白种子增殖实验可区分不同类型的α-突触核蛋白病
Wei Dai,Hao Lin,Hengxu Mao et al.
Wei Dai et al.
Introduction: Synucleinopathies are characterized by the misfolding and aggregation of α-synuclein (α-Syn) into pathogenic strains that seed Lewy-body pathology in neurons and/or glial cytoplasmic inclusions in oligoden...
Integrating epigenetic and immune biomarkers to enable dynamic precision therapy in triple-negative breast cancer [0.03%]
整合表观遗传和免疫生物标志物以在三阴性乳腺癌中实现动态精准治疗
Jabed Iqbal,Sue-Zann Chua
Jabed Iqbal