Comparative review of diagnostic techniques for DNA methylation analysis [0.03%]
DNA甲基化分析诊断技术比较研究评审报告
Luiza Loureiro de Araújo,Hiago Azevedo Cintra,Letícia Lopes Cabral Guimarães Fonseca et al.
Luiza Loureiro de Araújo et al.
Introduction: DNA methylation is a crucial epigenetic modification regulating gene expression, essential for embryonic development, cellular differentiation, and disease susceptibility. Aberrant methylation is associated ...
Human papillomavirus viral load as promising surrogate biomarker of cervical cancer risk and clinical outcome [0.03%]
人乳头瘤病毒载量有望成为宫颈癌风险和临床结局的可靠替代生物标志物
Ralph-Sydney Mboumba Bouassa,Jonathan Muwonga Tukisadila,Hugues Loemba et al.
Ralph-Sydney Mboumba Bouassa et al.
Introduction: Cervical precancerous lesions and cancer are caused by persistent oncogenic high-risk human papillomavirus (HR-HPV). Molecular HPV DNA testing has recently replaced cytology as the preferred primary screenin...
α-synuclein PET imaging: early human evidence and the path toward clinical proof-of-concept [0.03%]
α-突触核蛋白正电子发射断层显像（PET）成像：早期人体研究证据及临床概念验证之路
Luca Filippi,Nicoletta Urbano
Luca Filippi
Introduction: Aggregation of misfolded α-synuclein is the defining pathological hallmark of synucleinopathies, including Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy (MSA). Despite major ad...
Mehmet Kayaalp,Emre Yekedüz,Yüksel Ürün
Mehmet Kayaalp
Introduction: Liquid biopsy is a noninvasive diagnostic and monitoring method that provides molecular information about disease by analyzing tumor-derived biomaterials obtained from body fluids - primarily blood, as well ...
Predicting 28-day all-cause mortality in critically ill ischemic stroke patients using white blood cell-to-hemoglobin ratio and dual-feature selection machine learning models [0.03%]
基于白细胞/血红蛋白比值和双特征选择机器学习模型预测危重缺血性卒中患者的28天全因死亡率
Hailong Yu,Aipeng Hu,Xiaoyun Huang et al.
Hailong Yu et al.
Background: The white blood cell-to-hemoglobin ratio (WHR) is a composite biomarker of inflammation and nutrition, but its prognostic role in critically ill ischemic stroke (IS) patients is unclear. ...
Evaluating emerging molecular diagnostics for severe infections in neutropenic patients with hematological malignancies [0.03%]
评估分子诊断在血液系统恶性肿瘤中性粒细胞减少症患者重症感染中的应用价值
Mariana Pitombeira Liborio,Anna Maria Peri,Patrick N A Harris
Mariana Pitombeira Liborio
Introduction: Neutropenia significantly increases infection risk in hematologic malignancies patients, when clinical signs are often subtle and fever may be the only indicator. Molecular diagnostic methods promise faster,...
Blood-based biomarkers for Alzheimer's disease. 'Treat the test, not the patient?'; are we ready to defy Osler? [0.03%]
针对阿尔茨海默病的血液生物标志物。考维德时代下的新医学原则：“检验前行为的影响比治疗更为重要”？我们准备好了挑战奥斯勒的原则吗？
Paul Connon,Mary Clare McKenna,Sandra E Black et al.
Paul Connon et al.
Fusion genes in precision oncology: prostate cancer as a diagnostic case study [0.03%]
精确肿瘤学中的融合基因：以前列腺癌为例的诊断研究
Rebecca A Morgan,Gary Hardiman
Rebecca A Morgan
Introduction: Fusion genes represent one of the most specific molecular alterations in human cancer and have long served as important diagnostic and therapeutic biomarkers. Advances in next-generation sequencing have driv...
Clinical utility of novel point-of-care Amnioquick card tests for the assessment of pre-labour rupture of fetal membranes [0.03%]
新型的胎膜早破床旁筛查方法Amnioquick卡片检测的临床应用价值研究
George Uchenna Eleje,Emmanuel Chukwubuikem Egwuatu,Chichi Ukoha et al.
George Uchenna Eleje et al.
Introduction: Pre-labor rupture of membranes (PROM) remains a major contributor to adverse maternal and neonatal outcomes, particularly in settings where diagnostic uncertainty delays appropriate intervention. Novel point...
Liquid biopsy for biliary tract cancer: available evidence and future research directions [0.03%]
液体活检技术在胆道癌中的应用：现有证据及未来研究方向
Enes Erul,Angela Dalia Ricci,Mario Della Mura et al.
Enes Erul et al.
Introduction: Biliary tract cancers (BTCs) are molecularly heterogeneous, and early genomic profiling is becoming increasingly important for treatment decisions. Because tissue sampling is often limited or inadequate, the...