Preconception carrier screening and prenatal diagnosis in thalassemia and hemoglobinopathies: challenges and future perspectives [0.03%]
地中海贫血和血红蛋白病的孕前携带者筛查与产前诊断：挑战及未来前景
Joanne Traeger-Synodinos,Cornelis L Harteveld
Joanne Traeger-Synodinos
Hemoglobinopathies constitute the most common severe monogenic disorders worldwide, with an increasing global burden each year. The benefit of applying programmes for preconception carrier screening, with the option of prenatal diagnosis, t...
Paper-based analytical devices for clinical diagnosis: recent advances in the fabrication techniques and sensing mechanisms [0.03%]
临床诊断用纸基分析器件：制备技术和传感机制的最新进展
Mazhar Sher,Rachel Zhuang,Utkan Demirci et al.
Mazhar Sher et al.
There is a significant interest in developing inexpensive portable biosensing platforms for various applications including disease diagnostics, environmental monitoring, food safety, and water testing at the point-of-care (POC) settings. Cu...
W Michael Dunne Jr,Magali Jaillard,Olivier Rochas et al.
W Michael Dunne Jr et al.
Antimicrobial susceptibility testing is key in modern clinical microbiology. With pandemic emergence of (multi-)antibiotic resistance, methods to detect and quantify resistance of clinically important bacterial species are imperative. Histo...
The effect of main urine inhibitors on the activity of different DNA polymerases in loop-mediated isothermal amplification [0.03%]
主要尿抑制剂对环介导等温扩增中不同DNA聚合酶活性的影响研究
Jekaterina Jevtuševskaja,Katrin Krõlov,Indrek Tulp et al.
Jekaterina Jevtuševskaja et al.
Background: The use of rapid amplification methods to detect pathogens in biological samples is mainly limited by the amount of pathogens present in the sample and the presence of inhibiting substances. Inhibitors can aff...
Using biomarkers to predict and to prevent cardiotoxicity of cancer therapy [0.03%]
应用生物标志物预测和预防癌症治疗的心脏毒性
Daniela Cardinale,Gina Biasillo,Michela Salvatici et al.
Daniela Cardinale et al.
Cardiotoxicity is a common complication that may compromise the clinical effectiveness of anticancer therapy. The current standard for monitoring cardiac function detects cardiotoxicity only when a functional impairment has already occurred...
Genomics pipelines and data integration: challenges and opportunities in the research setting [0.03%]
基因组学流水线和数据集成：研究中的挑战与机遇
Jeremy Davis-Turak,Sean M Courtney,E Starr Hazard et al.
Jeremy Davis-Turak et al.
The emergence and mass utilization of high-throughput (HT) technologies, including sequencing technologies (genomics) and mass spectrometry (proteomics, metabolomics, lipids), has allowed geneticists, biologists, and biostatisticians to bri...
Clinical performance of the Solana® Point-of-Care Trichomonas Assay from clinician-collected vaginal swabs and urine specimens from symptomatic and asymptomatic women [0.03%]
Solana床旁滴虫检测笔在有症状和无症状女性阴道拭子和尿液标本中的临床验证研究
C A Gaydos,J Schwebke,J Dombrowski et al.
C A Gaydos et al.
Background: Solana® (Quidel) is a new rapid (
Paul C Adams
Paul C Adams
Michael A Arnold,Fredric G Barr
Michael A Arnold
A classification of rhabdomyosarcoma (RMS) with prognostic relevance has primarily relied on clinical features and histologic classification as either embryonal or alveolar RMS. The PAX3-FOXO1 and PAX7-FOXO1 gene fusions occur in 80% of cas...
The cobas® 6800/8800 System: a new era of automation in molecular diagnostics [0.03%]
全自动分子诊断平台cobas 6800/8800系统：开启自动化分子诊断新时代
Bryan Cobb,Christian O Simon,Susan L Stramer et al.
Bryan Cobb et al.
Molecular diagnostics is a key component of laboratory medicine. Here, the authors review key triggers of ever-increasing automation in nucleic acid amplification testing (NAAT) with a focus on specific automated Polymerase Chain Reaction (...