Next-generation sequencing for laboratory diagnosis of infectious diseases [0.03%]
新一代测序在传染病实验室诊断中的应用
Susanna K P Lau,Patrick C Y Woo
Susanna K P Lau
Exploring sex-specific genetic architecture of coronary artery disease in Tehran: a cardiometabolic genetic study [0.03%]
德黑兰冠心病性别特异性遗传结构探索：一项心血管代谢性遗传学研究
Leila Najd-Hassan-Bonab,Maryam S Daneshpour,Mojtaba Jafarinia et al.
Leila Najd-Hassan-Bonab et al.
Background: The development of coronary artery disease (CAD) is influenced by sex and genetic factors. Genome-wide association studies (GWAS) have linked genetic loci to CAD, mostly in European populations. The study aims...
HNF1B polymorphisms and endometrial cancer risk: validation of identified loci and evaluation of novel variants [0.03%]
遗传多态性与子宫内膜癌风险的关系：已确定位点的验证及新型变异体的评估
Fang Liu,Chunmei Li,Man Di et al.
Fang Liu et al.
Background: This study aimed to validate HNF1B single nucleotide polymorphisms (SNPs) associated with endometrial cancer risk in a Chinese Han population and explore novel SNPs. Our findings enhance the understanding of g...
Diagnosis and management of invasive fungal diseases by next-generation sequencing: are we there yet? [0.03%]
新一代测序技术在侵袭性真菌病的诊断和治疗中的应用：我们准备好了吗？
N Esther Babady,Charles Y Chiu,Arryn Craney et al.
N Esther Babady et al.
Introduction: Invasive fungal diseases (IFDs) are a serious threat to immunocompromised patients. Routine diagnostic methods have limited performance in identifying IFDs. Next-generation sequencing (NGS), including metage...
TRIB3 overexpression predicts malignant progression and poor prognosis in human solid tumors: bioinformatics validation and clinical significance [0.03%]
TRIB3过表达预测人类实体肿瘤的恶性进展和不良预后：生物信息学验证及临床意义
Kangping Yang,Benjie Li,Xuan Xu et al.
Kangping Yang et al.
Introduction: Overexpression of tribbles homolog 3 (TRIB3) has been reported in various cancers, yet its clinical significance remains contentious. This study aims to elucidate the association between TRIB3 overexpression...
Promising biomarkers of Kawasaki disease: markers that aid in diagnosis [0.03%]
有希望成为川崎病生物标志物的指标：有助于诊断的标记物
Mindy Ming-Huey Guo,Ho-Chang Kuo
Mindy Ming-Huey Guo
Introduction: Currently the diagnosis of Kawasaki disease is still heavily reliant on clinical criteria which may be subject to interpretation or mimic other common febrile diseases of childhood. Biomarkers that can aid i...
Strengths and limitations of molecular diagnostics for Pneumocystis jirovecii pneumonia [0.03%]
分子诊断治疗隐球肺孢子菌肺炎的优缺点
Lottie Brown,Alexandre Alanio,Mario Cruciani et al.
Lottie Brown et al.
Introduction: While Pneumocystis pneumonia (PcP) remains a major AIDS-defining disease, the majority of cases of PcP now present in the HIV-negative cohort, causing significant mortality. PcP PCR diagnosis is not novel, a...
Genetic-based diagnostics of Parkinson's disease and other Parkinsonian syndromes [0.03%]
基于遗传的帕金森病及其他帕金森综合征诊断方法
Emma N Somerville,Ziv Gan-Or
Emma N Somerville
Introduction: Parkinson's disease (PD) is a complex disorder with vast clinical heterogeneity. Recent genetic, imaging and clinical evidence suggest that there are multiple subtypes of PD, and perhaps even distinct clinic...
John R Heard,Michael Ahdoot,Dan Theodorescu et al.
John R Heard et al.
Introduction: There have been many recent advancements in the treatment of bladder cancer including the approval of novel intravesical agents for non-muscle-invasive disease and systemic-targeted therapeutics for muscle-i...