Personalized medicine in colorectal cancer: a comprehensive study of precision diagnosis and treatment [0.03%]
结直肠癌的精准诊断与治疗研究综述——个体化医学时代的到来
Fatemeh Gila,Somayeh Khoddam,Zahra Jamali et al.
Fatemeh Gila et al.
Colorectal cancer is a common and fatal disease that affects many people globally. CRC is classified as the third most prevalent cancer among males and the second most frequent cancer among females worldwide. The purpose of this article is ...
Technological advances in clinical individualized medication for cancer therapy: from genes to whole organism [0.03%]
临床个体化抗癌药物治疗的科技进步：从基因到整体机体
Jiejing Kai,Xueling Liu,Meijia Wu et al.
Jiejing Kai et al.
Efforts have been made to leverage technology to accurately identify tumor characteristics and predict how each cancer patient may respond to medications. This involves collecting data from various sources such as genomic data, histological...
Genetic and non-genetic factors influencing the therapeutic response of valproic acid in pediatric epileptic patients [0.03%]
影响丙戊酸盐治疗儿童癫痫患者的遗传和非遗传因素
Changsong Wu,Jianghuan Zheng,Yanling Pan et al.
Changsong Wu et al.
Aims: Considerable inter-individual variability in the efficacy of valproic acid (VPA) has been reported, with approximately 20-45% of patients failing to achieve satisfactory seizure control after VPA monotherapy. The ai...
Individualized psychiatric care: integration of therapeutic drug monitoring, pharmacogenomics, and biomarkers [0.03%]
个体化精神疾病诊疗：治疗性药物监测、药物基因组学和生物标志物的整合
Sara Salatin,Ali Reza Shafiee-Kandjani,Samin Hamidi et al.
Sara Salatin et al.
Personalized treatment optimization considers individual clinical, genetic, and environmental factors influencing drug efficacy and tolerability. As evidence accumulates, these approaches may become increasingly integrated into standard psy...
Pharmacogenomics education in China and the United States: advancing personalized medicine [0.03%]
中美药理基因组学教育：推进个性化医疗
Quanlin Wang,Shusen Sun,Wei Zhang et al.
Quanlin Wang et al.
Pharmacogenomics (PGx), an integral part of functional genomics and molecular pharmacology, has evolved significantly over the past decade. Our study reveals that PGx education in China and the United States has made substantial progress, w...
Identification of novel variants of XPA and POLH/XPV genes in xeroderma pigmentosum patients in Vietnam [0.03%]
越南着色性干皮病患者中XPA和POLH/XPV基因新变异的鉴定
Thi Lan Anh Luong,Thu Lan Hoang,Duc Phan Tran et al.
Thi Lan Anh Luong et al.
Xeroderma pigmentosum (XP) disorder is recognized as a genetic condition inherited by autosomal recessive fashion. XP results from a defective DNA repair mechanism that significantly increases skin cancer risk. Fifteen Vietnamese patients w...
Association between PRNCR1, PAX8AS1, MEG3, and PTENP1 gene polymorphisms and breast cancer risk [0.03%]
PRNCR1、PAX8AS1、MEG3和PTENP1基因多态性与乳腺癌风险的关系研究
Anoosha Asadi,Fatemeh Barati,Alireza Nakhaee et al.
Anoosha Asadi et al.
Aim: In this study, we examined the polymorphisms of PRNCR1 (rs13252298, rs1456315), PAX8-AS1 (rs4848320) MEG3 (rs7158663), PTENP1 (rs7853346) genes in BC patients and compared it with healthy individuals in an Iranian po...
Efficacy of trastuzumab deruxtecan in treating HER2-low breast cancer leptomeningeal metastasis: a case report [0.03%]
德鲁替康治疗HER2低表达型乳腺癌脑膜转移1例报告
Zeni Kharel,Sarah Stanford,Lauryn E Hemminger et al.
Zeni Kharel et al.
accepted at SABCS 2023, poster presented at SABCS 2023We report the efficacy of trastuzumab deruxtecan (T-DXd) in treating human epidermal growth factor receptor 2 (HER2) low, type ID leptomeningeal breast cancer (LMD) (with positive cerebr...
Lung cancer, platinum analog-based frontline treatment and pharmacogenetic limitations [0.03%]
肺癌一线含铂化疗及药物基因限制因素
Maryam Saqib,Zari Salahud Din,Sehrish Zafar et al.
Maryam Saqib et al.
Lung cancer has the highest mortality rate among all the highly prevalent neoplasia globally. The major concern with its frontline treatment-cisplatin, is the rapid progression of chemoresistance and multi-organ-based toxicities including h...
The rs2275738 variant of the adiponectin receptor 1 gene is associated with biopsy-proven nonalcoholic fatty liver disease [0.03%]
载脂蛋白受体1基因的rs2275738突变型与经活检证实的非酒精性脂肪肝病相关
Mitra Rostami,Touraj Mahmoudi,Abbas Ardalani et al.
Mitra Rostami et al.
Aim: Nonalcoholic fatty liver disease (NAFLD) is a significant health issue worldwide. This study investigated the effect of the adiponectin receptor 1 gene (ADIPOR1) polymorphism on susceptibility to NAFLD.Methods: Data from 330 participan...