Mutational signatures in appendiceal adenocarcinomas: potential for future personalization in hyperthermic intraperitoneal chemotherapy? [0.03%]
阑尾腺癌中的突变特征：未来腹腔热灌注化疗个体化的潜力？
Mason Vierra,Ryan Morgan,Oliver Eng
Mason Vierra
Cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (CRS/HIPEC) has become increasingly utilized in the treatment of appendiceal adenocarcinoma (AA) with peritoneal metastases. There are multiple intraperitoneal chemotherap...
Association of platelet ADP receptor variant rs1371097 with inadequate platelet response to aspirin in Indian patients [0.03%]
血小板ADP受体多态性rs1371097与印度患者阿司匹林反应不足相关性研究
Pandarisamy Sundaravadivel,Rita Christopher,Sadanandavalli Retnaswami Chandra et al.
Pandarisamy Sundaravadivel et al.
Aim: On-aspirin platelet reactivity, wherein patients show sub-optimal or no response to antiplatelet therapy, occurs in 5-60% of subjects. The genetic etiology of such reactivity in patients with vascular diseases, espec...
Hadi Mostafaei,Hanieh Salehi-Pourmehr,Fatemeh Sadeghi Ghyassi et al.
Hadi Mostafaei et al.
Objective: The study aims to develop an Evidence Gap Map (EGM) to summarize the current evidence cited in personalized medicine (PM) in bladder cancer, focusing on systematic reviews and high-level evidence syntheses. ...
Perceived understanding and psychosocial outcomes: employees' responses to learning results of workplace genetic testing [0.03%]
感知的理解和心理社会结果：员工对工作场所基因检测学习结果的反应
Elizabeth Charnysh,Sarah McCain,Alexandra Truhlar et al.
Elizabeth Charnysh et al.
Aims: This study explored employees' understanding of, and psychosocial responses to, workplace genetic testing (wGT) results. Materials & methods: ...
Regional disparities in access to gene therapies in the European Union, the United States, Japan, and China [0.03%]
欧盟、美国、日本和中国的基因治疗准入地区差异
Riya Mohan,Margaux Reckelbus,Pascal Borry
Riya Mohan
Understanding the regional differences in approved gene therapies, clinical trial development, and regulatory frameworks is crucial for ensuring equitable access and addressing justice issues in advanced therapeutics. This review aimed to e...
Clarifying a working definition for 'precision communication': a scoping review of medical literature on communication [0.03%]
澄清精准沟通的定义：医学文献中关于沟通的界定研究综述
Bao-Lam Pham,Brigitte N Durieux,Amanda Bianco et al.
Bao-Lam Pham et al.
Aims: While "tailored communication" and "precision medicine" have been well-defined in medical literature, the concept of "precision communication" in healthcare has yet to be clarified. We sought to review how "precisio...
Bridging the United States population diversity gaps in clinical research: roadmap to precision health and reducing health disparities [0.03%]
弥合美国人口多样性在临床研究中的差距：迈向精准医疗和减少健康差异之路地图
Youssef Roman
Youssef Roman
Precision medicine promises improved health outcomes by tailoring treatments to individual genetic and environmental factors. However, achieving this potential is hindered by persistent health disparities and the underrepresentation of raci...
Precision acute medical care through "-omic" analyses: a scoping review [0.03%]
组学分析在精准急性期医疗中的应用——系统综述研究
Cole Ettingoff,Megan Von Isenburg,Drew Birrenkott et al.
Cole Ettingoff et al.
Background: -Omics technologies - including genomics, transcriptomics, proteomics, and metabolomics - are increasingly used in acute care settings. However, the current extent of this research has not been systematically ...
Vancomycin individual dosing regimens via Bayesian simulation: a 5-year retrospective study on preterm and term neonates [0.03%]
基于贝叶斯模拟的万古霉素个体化剂量方案：一项为期5年的早产儿及足月婴儿回顾性研究
Lu Tan,Ailing Chao,Heng Liang et al.
Lu Tan et al.
Aim: Vancomycin dosing in neonates is challenging due to developmental pharmacokinetic variability. The study was to characterize vancomycin pharmacokinetics in a large cohort of preterm and term neonates and develop indi...
Global harmonization in advanced therapeutics: balancing innovation, safety, and access [0.03%]
全球先进治疗的协调化：平衡创新、安全和使用范围
Ankit Dahiya,Kartikey Singh,Anunav Ashish et al.
Ankit Dahiya et al.
Introduction: Advanced Therapy Medicinal Products (ATMPs), which include gene therapies, somatic cell therapies, and tissue-engineered products, are a new paradigm for treating previously intractable diseases. Their regen...