Association of XRCC gene family and CDH1 gene polymorphisms with gastric cancer risk in a Chinese population [0.03%]
XRCC基因家族和CDH1基因多态性与中国人胃癌风险的相关性研究
Yalan Sun,Ying Wang,Mengqiu Xiong et al.
Yalan Sun et al.
Background: Gastric carcinogenesis is associated with defects in DNA damage repair pathways, in which the XRCC gene family (XRCC1, XRCC5, and XRCC6) play an important role in DNA repair. It is also well known that the CDH...
The correlation between the polymorphism of lysolecithin acyltransferase (MBOAT7) rs641738 and liver fibrosis [0.03%]
溶血磷脂酰胆碱酰基转移酶(MBOAT7)rs641738多态性与肝纤维化的关系研究
Yuxia Yang,Xiang Chen,Huiqin Zhang et al.
Yuxia Yang et al.
Objective: We aimed to explore the relationship between the MBOAT7 rs641738 gene polymorphism and liver fibrosis and inflammation. Methods: ...
Head-to-head comparison of tyrosine kinase inhibitors in renal cell carcinoma using patient-derived cell culture [0.03%]
使用患者衍生的细胞培养物进行肾细胞癌中酪氨酸激酶抑制剂的对比研究
Aaron J Urquhart,Christian H Glass,Tyrone L R Humphries et al.
Aaron J Urquhart et al.
Background: Metastatic renal cell carcinoma (RCC) is often treated with a combination of immunotherapy and tyrosine kinase inhibitors (TKIs). Patient-derived RCC cells were cultured and inter-individual differences to tre...
The effect of genetic polymorphisms of AKT1 on PE susceptibility: a case-control study and insilico analysis [0.03%]
AKT1基因多态性对妊高征易感性的影响：一项病例对照研究和计算分析
Mahnaz Rezaei,Marzieh Ghasemi,Mohsen Saravani et al.
Mahnaz Rezaei et al.
Background: Preeclampsia (PE) is a gestational disease associated with developing hypertension and proteinuria. Aim: This study investi...
Personalized medicine in colorectal cancer: a comprehensive study of precision diagnosis and treatment [0.03%]
结直肠癌的精准诊断与治疗研究综述——个体化医学时代的到来
Fatemeh Gila,Somayeh Khoddam,Zahra Jamali et al.
Fatemeh Gila et al.
Colorectal cancer is a common and fatal disease that affects many people globally. CRC is classified as the third most prevalent cancer among males and the second most frequent cancer among females worldwide. The purpose of this article is ...
Technological advances in clinical individualized medication for cancer therapy: from genes to whole organism [0.03%]
临床个体化抗癌药物治疗的科技进步：从基因到整体机体
Jiejing Kai,Xueling Liu,Meijia Wu et al.
Jiejing Kai et al.
Efforts have been made to leverage technology to accurately identify tumor characteristics and predict how each cancer patient may respond to medications. This involves collecting data from various sources such as genomic data, histological...
Genetic and non-genetic factors influencing the therapeutic response of valproic acid in pediatric epileptic patients [0.03%]
影响丙戊酸盐治疗儿童癫痫患者的遗传和非遗传因素
Changsong Wu,Jianghuan Zheng,Yanling Pan et al.
Changsong Wu et al.
Aims: Considerable inter-individual variability in the efficacy of valproic acid (VPA) has been reported, with approximately 20-45% of patients failing to achieve satisfactory seizure control after VPA monotherapy. The ai...
Individualized psychiatric care: integration of therapeutic drug monitoring, pharmacogenomics, and biomarkers [0.03%]
个体化精神疾病诊疗：治疗性药物监测、药物基因组学和生物标志物的整合
Sara Salatin,Ali Reza Shafiee-Kandjani,Samin Hamidi et al.
Sara Salatin et al.
Personalized treatment optimization considers individual clinical, genetic, and environmental factors influencing drug efficacy and tolerability. As evidence accumulates, these approaches may become increasingly integrated into standard psy...
Pharmacogenomics education in China and the United States: advancing personalized medicine [0.03%]
中美药理基因组学教育：推进个性化医疗
Quanlin Wang,Shusen Sun,Wei Zhang et al.
Quanlin Wang et al.
Pharmacogenomics (PGx), an integral part of functional genomics and molecular pharmacology, has evolved significantly over the past decade. Our study reveals that PGx education in China and the United States has made substantial progress, w...
Identification of novel variants of XPA and POLH/XPV genes in xeroderma pigmentosum patients in Vietnam [0.03%]
越南着色性干皮病患者中XPA和POLH/XPV基因新变异的鉴定
Thi Lan Anh Luong,Thu Lan Hoang,Duc Phan Tran et al.
Thi Lan Anh Luong et al.
Xeroderma pigmentosum (XP) disorder is recognized as a genetic condition inherited by autosomal recessive fashion. XP results from a defective DNA repair mechanism that significantly increases skin cancer risk. Fifteen Vietnamese patients w...