Bridging the United States population diversity gaps in clinical research: roadmap to precision health and reducing health disparities [0.03%]
弥合美国人口多样性在临床研究中的差距：迈向精准医疗和减少健康差异之路地图
Youssef Roman
Youssef Roman
Precision medicine promises improved health outcomes by tailoring treatments to individual genetic and environmental factors. However, achieving this potential is hindered by persistent health disparities and the underrepresentation of raci...
Precision acute medical care through "-omic" analyses: a scoping review [0.03%]
组学分析在精准急性期医疗中的应用——系统综述研究
Cole Ettingoff,Megan Von Isenburg,Drew Birrenkott et al.
Cole Ettingoff et al.
Background: -Omics technologies - including genomics, transcriptomics, proteomics, and metabolomics - are increasingly used in acute care settings. However, the current extent of this research has not been systematically ...
Vancomycin individual dosing regimens via Bayesian simulation: a 5-year retrospective study on preterm and term neonates [0.03%]
基于贝叶斯模拟的万古霉素个体化剂量方案：一项为期5年的早产儿及足月婴儿回顾性研究
Lu Tan,Ailing Chao,Heng Liang et al.
Lu Tan et al.
Aim: Vancomycin dosing in neonates is challenging due to developmental pharmacokinetic variability. The study was to characterize vancomycin pharmacokinetics in a large cohort of preterm and term neonates and develop indi...
Global harmonization in advanced therapeutics: balancing innovation, safety, and access [0.03%]
全球先进治疗的协调化：平衡创新、安全和使用范围
Ankit Dahiya,Kartikey Singh,Anunav Ashish et al.
Ankit Dahiya et al.
Introduction: Advanced Therapy Medicinal Products (ATMPs), which include gene therapies, somatic cell therapies, and tissue-engineered products, are a new paradigm for treating previously intractable diseases. Their regen...
Artificial intelligence: its potential in personalized public health strategies and genetic data analysis: a narrative review [0.03%]
人工智能在个性化公共卫生策略和基因数据分析中的潜力：叙述性综述
Gülcan Demir,Zeynep Yegin
Gülcan Demir
This review comprehensively evaluates personalized public health strategies using artificial intelligence (AI) in disease prediction/management and genetic data analysis. In the field of healthcare, AI has achieved significant advancements ...
Francesco Pepe,Tancredi Didier Bazan Russo,Valerio Gristina et al.
Francesco Pepe et al.
Lung cancer (LC) remains the leading cause of cancer-related mortality worldwide, with most cases diagnosed at advanced stages, resulting in poor survival rates. Early detection significantly improves outcomes, yet current screening methods...
Özkan Bağcı,Batuhan Şanlıtürk,Ebru Marzioğlu Özdemir et al.
Özkan Bağcı et al.
Aim: In this study, we aimed to reveal the sequence analysis of 69 pharmacogenes in 635 patients and the clinical explanation of variants. Materials and m...
How people undergoing genomic sequencing interpret and react to varied secondary findings with limited actionability [0.03%]
基因组测序过程中的人们如何解释和应对具有有限可操作性的各种次要发现
Haoyang Yan,Christine M Rini,Ann Katherine M Foreman et al.
Haoyang Yan et al.
Purpose: To investigate patient reactions to and understanding of secondary genomic findings with limited to no medical actionability (LMA-SFs) from diagnostic genome sequencing. ...
Association of miR-21 gene polymorphisms with cognitive function in patients with systemic lupus erythematosus [0.03%]
miR-21基因多态性与系统性红斑狼疮患者认知功能的关联研究
Tiantian Wei,Jing Shen,Lijun He et al.
Tiantian Wei et al.
Objectives: The genetic variant rs13137 of miR-21 is associated with susceptibility in many diseases. However, the association with cognitive dysfunction (CD) in Chinese patients with systemic lupus erythematosus (SLE) re...
Developing the Workplace Learning Social System: considerations for genomics implementation and workforce preparedness [0.03%]
工作场所学习社会系统的开发：关于基因组学实施和劳动力准备的考虑因素
Alice Kim,Amy Nisselle,Louise Keogh et al.
Alice Kim et al.
Innovations, such as genomics, are expected to transform the practice of the healthcare workforce. Workplace learning is an established and fundamental component of healthcare workforce training. We propose that it can be leveraged to facil...