The association between DNA repair genes polymorphisms and cisplatin-induced ototoxicity in cancer patients: a systematic review [0.03%]
DNA修复基因多态性与顺铂引起的癌症患者耳毒性的关联：系统评价
Nabil E Omar,Rana Mekkawi,Salma Said et al.
Nabil E Omar et al.
Introduction: Ototoxicity is a dose-limiting toxicity of cisplatin. Several DNA repair gene polymorphisms have been investigated for their association with cisplatin-induced ototoxicity (CIO), but their predictive value r...
Lineage-specific transcriptomic signatures and therapeutic target discovery in myeloid and lymphoid leukemias [0.03%]
髓系和淋巴系白血病中的系别特异性转录特征及治疗靶点发现
Başak Özay,Onur Ateş,Yağmur Kiraz
Başak Özay
Aim: Leukemias are heterogenous hematologic malignancies broadly classified into myeloid and lymphoid lineages, each with distinct molecular and clinical features. Here we aime to identify lineage-specific molecular vulne...
A population pharmacokinetic model for early follow-up dosing of tacrolimus in Tunisian kidney transplant recipients [0.03%]
用于突尼斯肾移植受者的他克莫司早期随访剂量的群体药代动力学模型
Amani Abderahmene,Marith I Francke,Meriam Ammar et al.
Amani Abderahmene et al.
Introduction: Tacrolimus is the cornerstone of immunosuppressive therapy in kidney transplantation. However, it exhibits significant pharmacokinetic (PK) variability among patients. Therefore, Population Pharmacokinetic (...
Association between CYP11B2 rs1799998 genetic variant with essential hypertension and antihypertensive response [0.03%]
遗传多态性CYP11B2 rs1799998与原发性高血压及降压反应之间的关系分析
Dalia Abdelrazaq,Yazun Jarrar,Hussein Alhawari et al.
Dalia Abdelrazaq et al.
Background: Essential hypertension (EH) is influenced by genetic and environmental factors. The CYP11B2 gene, encoding aldosterone synthase, plays a major role in blood pressure regulation. This study investigated the ass...
Homozygous GBA1 p.T82I variant in type 1 Gaucher disease: clinical and biochemical characterization [0.03%]
GBA1 p.T82I纯合子变异型1型戈谢病的临床和生化特征
Selin Genc,Filiz Mercantepe,Fahri Bayram
Selin Genc
Background: Gaucher disease (GD) is the most common lysosomal storage disorder caused by biallelic pathogenic variants in GBA1, resulting in deficient β-glucocerebrosidase activity. Clinical characterization of rare GBA1...
The genetic association of IL-17A rs8193036 with the susceptibility to Alzheimer's disease [0.03%]
IL-17A基因多态性与阿尔茨海默病遗传易感性的相关性分析
Yanni Luo,Jinpeng Huang,Zhongcheng An et al.
Yanni Luo et al.
Aim: This study aims to validate the relevance of IL-17A rs8193036 polymorphisms in susceptibility to Alzheimer's disease. Materials and methods: ...
Molecularly guided precision therapy in metastatic adamantinoma: a case report [0.03%]
分子导向的精准治疗腺瘤样鳞癌肝转移一例报告
Aram A Musaelyan,Svetlana V Odintsova,Alexander O Ivantsov et al.
Aram A Musaelyan et al.
Adamantinoma is a rare bone tumor characterized by a propensity for local recurrence and distant metastasis. Management of metastatic disease remains challenging owing to the absence of standardized therapy and the limited efficacy of conve...
Study of association between rs72703442 and rs55683539 genetic variants in MIR31HG and the risk of breast cancer [0.03%]
MIR31HG基因rs72703442和rs55683539遗传变异与乳腺癌风险的相关性研究
Omar Jamal Khalaf Al-Nasani,Somayeh Reiisi
Omar Jamal Khalaf Al-Nasani
Background: Genetic variations in non-coding RNAs, including MIR31HG, which hosts microRNA-31, have been linked to breast cancer (BC) susceptibility. Current study aimed to evaluate the correlation between two MIR31HG var...
Evaluating the impact of infectious disease pharmacy services on voriconazole dose individualization in pediatric oncology [0.03%]
评估传染病药学服务对儿科肿瘤学伏立康唑剂量个体化的影响
Mai Samy Azab,Dalia Makhlouf,Omneya Ahmed et al.
Mai Samy Azab et al.
Background: The application of personalized medication management for Voriconazole(VCZ), such as therapeutic drug monitoring (TDM), is the gold standard for attaining therapeutic goals in invasive fungal infections. Infec...
Maria Cristina Sini,Milena Casula,Marina Pisano et al.
Maria Cristina Sini et al.
Melanoma is a malignant tumour arising from melanocytes and is the most aggressive type of skin cancer. In advanced disease standard treatments are largely ineffective. About 40% of cutaneous melanomas carry BRAF mutations-more common in yo...