Evaluation of pharmacogenomic information in drug labeling: a case study from Jordan [0.03%]
一项药物标签中的药理基因组学信息评估案例研究：以约旦为例
Yazun Jarrar,Nancy Hakooz,Mays Abu Ajamieh et al.
Yazun Jarrar et al.
Background: Pharmacogenomics (PGx) examines how genetic variations influence individual responses to medications, enabling more precise drug and dose selection. Drug labeling communicates PGx information to healthcare pro...
Gastric cancer risk and BRCA1/2 mutations: a systematic review and meta-analysis [0.03%]
BRCA1/2基因突变与胃癌风险的系统评价和meta分析
Francisco Cezar Aquino de Moraes,Gustavo Tadeu Freitas Uchôa Matheus,Maria Eduarda Cavalcanti Souza et al.
Francisco Cezar Aquino de Moraes et al.
Background: Gastric cancer is an aggressive and heterogeneous disease, primarily sporadic, with only 1-3% of cases being hereditary. However, gastric cancer is a component of several hereditary cancer syndromes. The BRCA1...
Effect of miRNA gene polymorphisms on prostate cancer susceptibility: a case-control study and an updated meta-analysis [0.03%]
微小核糖核酸基因多态性与前列腺癌易感性的关联：一项病例对照研究和系统综述及meta分析
Sourabh Sharma,Rahul Gupta,Jyotdeep Kour Raina et al.
Sourabh Sharma et al.
Background: Prostate cancer (CaP) is the most commonly diagnosed malignant tumor and the leading cause of cancer-related deaths among men. Due to their potential functional significance, microRNA genes are considered prom...
Enhancing Parkinson's disease prediction using meta-heuristic optimized machine learning models [0.03%]
基于元启发式优化机器学习模型的帕金森病预测增强方法
Afeez A Soladoye,David B Olawade,Adebimpe O Esan et al.
Afeez A Soladoye et al.
Parkinson's disease is a progressive neurological disorder affecting movement and cognition. Early detection is crucial but challenging with traditional methods. This study applies meta-heuristic optimization to enhance machine learning pre...
Mutational signatures in appendiceal adenocarcinomas: potential for future personalization in hyperthermic intraperitoneal chemotherapy? [0.03%]
阑尾腺癌中的突变特征：未来腹腔热灌注化疗个体化的潜力？
Mason Vierra,Ryan Morgan,Oliver Eng
Mason Vierra
Cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (CRS/HIPEC) has become increasingly utilized in the treatment of appendiceal adenocarcinoma (AA) with peritoneal metastases. There are multiple intraperitoneal chemotherap...
Association of platelet ADP receptor variant rs1371097 with inadequate platelet response to aspirin in Indian patients [0.03%]
血小板ADP受体多态性rs1371097与印度患者阿司匹林反应不足相关性研究
Pandarisamy Sundaravadivel,Rita Christopher,Sadanandavalli Retnaswami Chandra et al.
Pandarisamy Sundaravadivel et al.
Aim: On-aspirin platelet reactivity, wherein patients show sub-optimal or no response to antiplatelet therapy, occurs in 5-60% of subjects. The genetic etiology of such reactivity in patients with vascular diseases, espec...
Hadi Mostafaei,Hanieh Salehi-Pourmehr,Fatemeh Sadeghi Ghyassi et al.
Hadi Mostafaei et al.
Objective: The study aims to develop an Evidence Gap Map (EGM) to summarize the current evidence cited in personalized medicine (PM) in bladder cancer, focusing on systematic reviews and high-level evidence syntheses. ...
Perceived understanding and psychosocial outcomes: employees' responses to learning results of workplace genetic testing [0.03%]
感知的理解和心理社会结果：员工对工作场所基因检测学习结果的反应
Elizabeth Charnysh,Sarah McCain,Alexandra Truhlar et al.
Elizabeth Charnysh et al.
Aims: This study explored employees' understanding of, and psychosocial responses to, workplace genetic testing (wGT) results. Materials & methods: ...
Regional disparities in access to gene therapies in the European Union, the United States, Japan, and China [0.03%]
欧盟、美国、日本和中国的基因治疗准入地区差异
Riya Mohan,Margaux Reckelbus,Pascal Borry
Riya Mohan
Understanding the regional differences in approved gene therapies, clinical trial development, and regulatory frameworks is crucial for ensuring equitable access and addressing justice issues in advanced therapeutics. This review aimed to e...
Clarifying a working definition for 'precision communication': a scoping review of medical literature on communication [0.03%]
澄清精准沟通的定义：医学文献中关于沟通的界定研究综述
Bao-Lam Pham,Brigitte N Durieux,Amanda Bianco et al.
Bao-Lam Pham et al.
Aims: While "tailored communication" and "precision medicine" have been well-defined in medical literature, the concept of "precision communication" in healthcare has yet to be clarified. We sought to review how "precisio...