Genome diagnostics: a pillar of twenty-first century healthcare and precision medicine [0.03%]
基因诊断：二十一世纪医疗服务和精准医疗的重要支柱
Manjunath Dammalli,Bhavya S G,K R Maruthi et al.
Manjunath Dammalli et al.
Genomic diagnostics is revolutionizing disease management and forms the cornerstone of precision medicine. This review details the multi-stage operational process of genomic testing, encompassing patient counseling, sample logistics, high-t...
The role of real-world data and real-world evidence in advancing regulatory science and targeted therapeutics: a narrative review from the United States perspective [0.03%]
真实世界数据和真实世界证据在推进监管科学和精准治疗方面的作用：美国视角的叙事综述
Emily Nagel,Youssef M Roman
Emily Nagel
Randomized controlled trials (RCTs) encounter feasibility gaps when addressing rare genetic disorders and molecularly defined patient subgroups. The U.S. Food and Drug Administration has increasingly integrated real-world evidence (RWE) int...
Association between polymorphisms in microRNA biosynthesis genes and acute lymphoblastic leukemia susceptibility in Chinese children and adolescents [0.03%]
中国儿童及青少年微小核糖核酸生物合成基因多态性与急性淋巴细胞白血病易感性的关联研究
Xiaoqing Cao,Lingyun Wang,Yurou Kang et al.
Xiaoqing Cao et al.
Aim: This study investigated associations between SNPs in miRNA-related genes (DROSHA, DGCR8, AGO1, TNRC6B) and acute lymphoblastic leukemia (ALL) susceptibility in Chinese children and adolescents. ...
Dual testing with immunohistochemistry and PCR for enhanced accuracy in dMMR/MSI detection in Greek colorectal cancer population: the impact of retesting [0.03%]
希腊结直肠癌人群中dMMR/MSI检测的双重免疫组化和PCR联合检测策略：复测的影响分析
Panagiotis Travlos,Alexandros Pergaris,Andreas C Lazaris et al.
Panagiotis Travlos et al.
Background: Deficient mismatch repair (dMMR) and microsatellite instability (MSI) are pivotal biomarkers in colorectal cancer (CRC). This study aimed to evaluate their prevalence in a Greek CRC cohort and assess the corre...
Study on miRNA-146a-5p rs2910164 polymorphism in attention deficit and hyperactive disorder occurrence and development [0.03%]
关于miRNA-146a-5prs2910164多态性在注意缺陷多动障碍发生发展中的研究
Wenmin Zhuang,Xuemin Ding,Haixia Luo et al.
Wenmin Zhuang et al.
Objectives: This study investigated the role of miR-146a-5p rs2910164 polymorphism in attention deficit hyperactivity disorder (ADHD). Methods: ...
Machine learning-enabled early risk stratification of β-Iactam-induced electrolyte imbalances [0.03%]
基于机器学习的β-内酰胺类抗生素所致电解质紊乱早期风险分层研究
Inho Ryu,Da Hoon Lee,Hyeonwoo Cho et al.
Inho Ryu et al.
Aims: To estimate the incidence of β-lactam/β-lactamase inhibitor - associated electrolyte imbalances and develop an internally validated, interpretable prediction model for early risk identification. ...
A review on prognostic biomarker and phytocompound-mediated modulation of signaling pathways in colorectal cancer [0.03%]
结直肠癌预后生物标志物和植物化合物介导的信号通路调节的研究进展综述
Bhavyaa Krishnakumar,Benedict Christopher Paul,Sabina Evan Prince et al.
Bhavyaa Krishnakumar et al.
Primary objective: This review aims to summarize and synthesize current knowledge on prognostic biomarkers in colorectal cancer (CRC). Rationale: ...
MLH1 rs63749795 variant confers increased risk for endometriosis: a genetic association study [0.03%]
MLH1 Rs63749795变异增加子宫内膜异位症发病风险的遗传关联研究
Niloofar Nazarikhah,Mohammad Javad Mokhtari
Niloofar Nazarikhah
Aims: The present study aimed to investigate the association between two MutL homolog 1 (MLH1) single-nucleotide polymorphisms (SNPs), rs63749795 and rs63749820, and the risk of endometriosis. ...
Association of XRCC4 and XRCC5 gene polymorphisms with polycystic ovarian syndrome in an Indian cohort [0.03%]
XRCC4和XRCC5基因多态性与印度人群多囊卵巢综合征的关系研究
Nikitha Sridhar,Gayathri Venkatakrishnan,Jiby Jolly Benjamin et al.
Nikitha Sridhar et al.
Aim: Polycystic ovary syndrome (PCOS) is a common endocrine disorder in Indian women, with prevalence influenced by ethnicity, lifestyle, and associated metabolic conditions. Given the emerging link between genomic instab...
OMICs data from Tunisian population: challenges and opportunities in the era of precision medicine [0.03%]
突尼斯人群的组学数据：精确医学时代的机遇与挑战
Chaima Hkimi,Hamza Yaiche,Selim Kamoun et al.
Chaima Hkimi et al.
Objective: The transition to precision medicine (PM) is revolutionizing healthcare by enabling diagnostics and treatments tailored to individual molecular and genetic profiles, with omics sciences at its core. In Tunisia,...