In silico characterization of MC4R variants reveals insights into Setmelanotide pharmacogenomics and personalized medicine for obesity [0.03%]
MC4R变异体的计算机表征揭示了Setmelanotide药物基因组学和肥胖个性化医疗的见解
Bruno Fonseca Nunes,Valdelúcia Maria Alves de Souza Grinevicius,Rozangela Curi Pedroza et al.
Bruno Fonseca Nunes et al.
Aims: The Melanocortin-4 receptor is a key regulator of energy homeostasis, and loss-of-function variants are the most common cause of monogenic obesity. This study aimed to characterize MC4R genetic variants and evaluate...
Predictive value of miR-132-3p for the onset of sepsis-induced acute kidney injury and its functional role during disease development [0.03%]
miR-132-3p预测脓毒症诱发急性肾损伤发病价值及其功能作用机制研究
CaiHua Lan,MeiRong Shen,Jing Liao et al.
CaiHua Lan et al.
Background: Sepsis-induced acute kidney injury (SI-AKI) is a prevalent critical complication characterized by delayed early diagnosis, inadequate prognosis evaluation, and unclear pathogenesis. MicroRNAs (miRNAs) are prom...
Strengthening the evidence base for precision medicine through the utilization of real-world data and real-world evidence: a narrative review from the U.S. perspective [0.03%]
利用真实世界数据和真实世界证据加强精准医疗循证研究体系：美国视角的文献综述
Emily Nagel,Youssef M Roman
Emily Nagel
The expansion of precision medicine has shifted toward individualized care tailored to a patient's genetic profile. While randomized controlled trials (RCTs) remain the gold standard for establishing efficacy, they often struggle to reflect...
Negin Akbari,Fatemeh Shaban,Jawad Malekzadeh et al.
Negin Akbari et al.
Purpose: The Surviving Sepsis Campaign (SSC) guidelines recommend norepinephrine to achieve a mean arterial pressure (MAP) target of ≥65 mmHg. While norepinephrine counteracts decreased vascularresistance and improves ti...
Prevalence and correlates of pharmacotherapy metabolized by CYP2C19, CYP2C9, CYP2D6, and UGT1A1 in the population sample [0.03%]
药物代谢酶和转运体人群基因分型项目（PGRN）：临床药理标志物的患病率及关联性研究
Nina D Anfinogenova,Vadim A Stepanov,Alina D Kuznetsova et al.
Nina D Anfinogenova et al.
Objective: Telecommunication-based cross-sectional study aimed to assess prevalence and health-related correlates of pharmacogenetic (PGx) drug administration. ...
Integrating host genetics in Helicobacter pylori infection: clinical insights for personalized eradication strategies [0.03%]
整合宿主遗传学的幽门螺旋杆菌感染：个性化根除策略的临床启示
Nazanin Khazali,Paria Ghadersoltani,Parastoo Saniee
Nazanin Khazali
Helicobacter pylori, a Group I carcinogen, infects over half the global population and is a leading cause of gastric cancer. Standard triple therapy with proton pump inhibitors (PPIs) and antibiotics frequently fails, often due to antibioti...
From genomes to metabolomes: adaptive science in personalized medicine [0.03%]
从基因组学到代谢组学：个性化医疗的适应性科学研究
Mélina Richard
Mélina Richard
Assessment of exonic polymorphism of IDH2, KRAS1, TP53, and BRAF2 using PCR-RFLP in hepatocellular carcinoma: a case-control study from Arunachal Pradesh and Sikkim [0.03%]
应用PCR-RFLP技术评估印度阿鲁纳恰尔邦和锡金肝细胞癌患者IDH2、KRAS1、TP53 和BRAF2 外显子多态性的病例对照研究
Chetan Chauhan,Vishal Kumar,Kanwar Narain et al.
Chetan Chauhan et al.
Introduction: The primary liver cancer of greatest concern is hepatocellular carcinoma (HCC). It covers almost 80% of liver cancer in the global population, and in the next two decades, it is expected to increase by 15%. ...
An integrated triple approach - TPMT phenotype, NUDT-15 genotype, and therapeutic drug monitoring of thiopurine metabolites for optimal clinical efficacy: a case series [0.03%]
TPMT表型、NUDT15基因型和硫嘌呤代谢物治疗药物监测的综合三联策略：病例系列分析
Silvia Joseph,Ratna Prabha,David Mathew Thomas et al.
Silvia Joseph et al.
Thiopurines, a widely used immunosuppressant for autoimmune and inflammatory condition, is associated with potentially severe adverse effects, particularly myelosuppression. Genetic polymorphisms in thiopurine S-methyltransferase (TPMT) and...
Association of a common SOD gene variant with ARHL risk: analysis by age, hearing threshold, and enzyme activity [0.03%]
SOD基因的常见变异体与ARHL风险相关性研究：按年龄、听力阈值及酶活性分析
Ali Morabbi,Hasti Balali,Ali Karimian
Ali Morabbi
Aim: This study aimed to investigate the association between the superoxide dismutase 2 (SOD2)-rs4880 polymorphism and age-related hearing loss (ARHL) in an Iranian population, assessing its impact on age, hearing loss se...