Joseph D McInerney,Emily Edelman,Therese Nissen et al.
Joseph D McInerney et al.
Genomic medicine holds the prospect of transforming clinical medicine and public health, but the current understanding of genetics and genomics among health professionals is a major impediment to the integration of genomic technologies into...
Lawrence J Lesko,Julie A Johnson
Lawrence J Lesko
Technology and clinical research has catalyzed the growth of pharmacogenomics and personalized medicine. However, adoption of genetic and genomic findings into clinical practice has occurred at a much slower pace. There are a variety of rea...
Genomic medicine: what are the challenges for the National Health Service? [0.03%]
基因组医学：National Health Service 面临的挑战是什么？
Heather Skirton,Leigh Jackson,Lesley Goldsmith et al.
Heather Skirton et al.
'Personalized medicine' is inextricably linked with current advances in genomics. Although initial claims about the power of genomic tests have been modified, they have the potential to inform a personalized approach to healthcare. Within t...
Michael Forstner
Michael Forstner
The ongoing developments in personalized healthcare are opening new possibilities for the optimization of the benefit-risk profiles of drugs based on the stratification of patients. Beyond this straightforward application of pharmacogenomic...
William E Kraus,Susanne B Haga,Howard L McLeod et al.
William E Kraus et al.
This article provides a meeting report from the Duke Center for Personalized Medicine 2012 Symposium, which took place in Durham, NC, USA, on 29 March 2012. The event titled 'At the Interface of Clinical Research and Clinical Medicine', foc...
The Learning-Adapting-Leveling model: from theory to hypothesis of steps for implementation of basic genome-based evidence in personalized medicine [0.03%]
学习适应分级模型：基于基本基因组证据的精准医疗实施步骤理论到假设
Jonathan A Lal,Anil Vaidya,Iñaki Gutiérrez-Ibarluzea et al.
Jonathan A Lal et al.
We see a backlog in the effective and efficient integration of personalized medicine applications such as genome-based information and technologies into healthcare systems. This article aims to expand on the steps of a published innovative ...
Holly Etchegary,Brenda Wilson
Holly Etchegary
There is growing expectation that advances in genomics herald the age of personalized medicine. Medicine has always been personal; however, the growing availability of genomic tools and technologies enable more precise risk stratification a...
"It's our DNA, we deserve the right to test!" A content analysis of a petition for the right to access direct-to-consumer genetic testing [0.03%]
“这是我们的DNA，我们有权利进行检测！”——一项关于获取直接面向消费者的基因检测权的请愿书的内容分析
Yeyang Su,Pascal Borry,Ina C Otte et al.
Yeyang Su et al.
Aims: Various companies are currently advertising or selling genetic tests over the internet using a model of provision referred to as 'direct-to-consumer' (DTC). This commercial offer of DTC genetic testing (GT) has fuel...
Characterization of CYP2D6 genotypes and metabolic profiles in the Portuguese population: pharmacogenetic implications [0.03%]
葡萄牙人口的CYP2D6基因型和代谢表型的特征及其药物基因组学意义
José Albuquerque,Carolina Ribeiro,Maria Eugenia G Naranjo et al.
José Albuquerque et al.
Aim: CYP2D6 codes for a protein that is vastly involved in the metabolism of various substances. This gene is highly polymorphic, which influences the enzymatic activity and contributes to the huge variability in the enzy...
Utilization of cardiac monitoring tests in women with nonmetastatic breast cancer treated with trastuzumab [0.03%]
赫赛汀治疗非转移性乳腺癌妇女的心脏监测检测的使用情况
Jaekyu Shin,Su-Ying Liang,Michael J Hassett et al.
Jaekyu Shin et al.
Aims: Trastuzumab, one of the best known examples of personalized medicine, requires regular cardiac monitoring because it can cause heart failure. We aimed to assess the utilization of cardiac monitoring in women with no...