Esmat Abdi,Saeid Latifi-Navid,Alireza Panahi
Esmat Abdi
Gynecological malignancies are one of the main causes of cancer-induced mortality. Despite remarkable recent therapeutic advances, current therapeutic options are not sufficient. Regarding the effect of long noncoding RNAs (lncRNAs) on cell...
Sara Green,Barbara Prainsack,Maya Sabatello
Sara Green
Recent advances in personalized cancer immunotherapy with immune checkpoint inhibitors, T cells and vaccines [0.03%]
免疫检查点抑制剂、T细胞和疫苗的个性化癌症免疫治疗最新进展
Elnaz Faghfuri
Elnaz Faghfuri
The results of genomic and molecular profiling of cancer patients can be effectively applied to immunotherapy agents, including immune checkpoint inhibitors, to select the most appropriate treatment. In addition, accurate prediction of neoa...
Successful management of delayed-onset adenosine deaminase deficiency with novel mutation [0.03%]
成功治疗一名腺苷脱氨酶新型基因突变导致的迟发性ADA缺乏症患者
Figen Çelebi Çelik,Özgen Soyöz,Selime Özen Bölük et al.
Figen Çelebi Çelik et al.
A 4-year-old boy presented with acute-onset autoimmune cytopenia with severe, persistent lymphopenia, autoimmune thyroiditis, elevated IgE and glucose 6-phosphate dehydrogenase enzyme deficiency. In immunologic evaluation, lower T, B and na...
Case Reports
Personalized medicine. 2024 Jan;21(1):11-19. DOI:10.2217/pme-2023-0111 2024
Diagnostic utility of the 23-gene expression profile test for an atypical intradermal melanocytic proliferation [0.03%]
用于诊断不典型真皮黑色素细胞增殖的23基因表达谱检测的价值
Etan Marks,Anais A Badia,Matthew S Goldberg
Etan Marks
Ancillary tests such as immunohistochemistry (IHC) and gene expression profile (GEP) testing may be needed to arrive at a definitive diagnosis for some atypical melanocytic neoplasms. A 34-year-old male with a family history of melanoma pre...
Case Reports
Personalized medicine. 2024 Jan;21(1):21-27. DOI:10.2217/pme-2023-0110 2024
Classification and immunotherapy assessment of lung adenocarcinoma based on coagulation-related genes [0.03%]
基于凝血相关基因的肺腺癌分类及免疫治疗评估
Yi Zhou,Wangju Fan,Jian Zhou et al.
Yi Zhou et al.
Introduction: This study on lung adenocarcinoma (LUAD), a common lung cancer subtype with high mortality. Aims: This study focuses on how tumor cell interactions affect immunotherapy responsiveness. Methods: Using public databases, we used ...
CYP2D6 genotyping and the clinical impact on outcomes in breast cancer tamoxifen-treated patients [0.03%]
乳腺癌患者他莫昔芬治疗的临床效果受CYP2D6基因型的影响
Gabriel Ramírez,Marcelo Vital,Carolina Vergara et al.
Gabriel Ramírez et al.
Aims: To report the distribution of allele frequencies of CYP2D6 gene and to evaluate their influence on the clinical outcomes of a group of breast cancer patients receiving adjuvant tamoxifen treatment from Uruguay. Patients & methods: 199...
De novo variants of dominant monogenic disorders in Vietnam detected by a noninvasive prenatal test: a case series [0.03%]
越南通过无创产前检测发现显性单基因疾病的新生变异病例系列研究
Nhat-Thang Tran,Son Ta Vo,Duy-Anh Nguyen et al.
Nhat-Thang Tran et al.
Background: Noninvasive prenatal tests for monogenic diseases (NIPT-SGG) have recently been reported as helpful in early-stage antenatal screening. Our study describes the clinical and genetic features of cases identified by NIPT-SGG. Mater...
Esmat Abdi,Saeid Latifi-Navid,Alireza Panahi et al.
Esmat Abdi et al.
Lung cancer (LC) imposes a significant burden, and is associated with high mortality and morbidity among malignant tumors. Aberrant expression of particular lncRNAs is closely linked to LC. LncRNA polymorphisms cause abnormal expression lev...
IL-6 gene polymorphism predicts PEGylated IFN-α treatment response in hepatitis B surface antigen-positive chronic hepatitis B patients [0.03%]
白细胞介素6基因多态性可预测阳性慢性乙肝患者聚乙二醇干扰素治疗应答
Xiaoqing Wang,Xiu Gu,Fengli Liu
Xiaoqing Wang
Background: Genetic polymorphism can affect the response to antiviral therapy of chronic hepatitis B (CHB) patients. Objective: The study examined the genetic association of the IL-6 rs1800796 polymorphism with PEGylated IFN-α (PegIFN-α) ...