B‑cell activating factor gene polymorphisms rs9514828 and rs1041569 increase preeclampsia risk [0.03%]
B细胞活化因子基因多态性rs9514828和rs1041569增加子痫前期风险
Kosar Shirvani Baghbabouie,Danial Jahantigh,Forough Forghani et al.
Kosar Shirvani Baghbabouie et al.
Aims: This study investigated the association between BAFF gene polymorphisms (rs1041569 and rs9514828) and preeclampsia (PE) susceptibility in an Iranian population, with a focus on disease severity and onset timing. ...
The historical evolution, technological transformation, and future vision of personalized medicine: a narrative review [0.03%]
个性化医学的历史演变、技术变革和未来愿景：叙述性回顾
Rümeysa Karaismailoğlu,Nilgün Bozbuğa
Rümeysa Karaismailoğlu
Introduction: The paradigm of personalized medicine is rapidly shifting from traditional, evidence-based genomics to advanced, data-driven ecosystems. Understanding this transition, supported by the computational tools of...
Clinical implication of transcriptional dysregulation in the SHH-GLI pathway involving the GLI1 rs61739569 (T>C) variant toward chronic obstructive pulmonary disease (COPD) in North Indians [0.03%]
北印度人中SHH-GLI信号通路转录调控异常（含GLI1rs61739569[T>C]变异）向慢性阻塞性肺疾病发展的临床意义
Nidhi Mahajan,Vishal Chopra,Kranti Garg et al.
Nidhi Mahajan et al.
Background: Chronic obstructive pulmonary disease (COPD) ranks among the leading causes of morbidity and mortality globally. Genomic susceptibility factors are acknowledged as critical modulators of disease variability an...
The impact of the rise of the chatbots: transforming genetics clinical delivery and research [0.03%]
聊天机器人兴起的影响：转型遗传学临床服务和研究
Susanne B Haga,Meghan MacNeal
Susanne B Haga
Aims: The rapid integration of genetics into clinical care and research has outpaced the supply of genetic professionals, creating persistent challenges in patient education, communication, and clinical follow-up. Chatbot...
Digital biomarkers in chronic disease management: a systematic review of personalization and ethical challenges [0.03%]
慢性病管理中数字生物标志物的个性化和伦理挑战系统综述
Shrivats Manikandan,Steiv Shore,Daniel Waszczuk et al.
Shrivats Manikandan et al.
Introduction: Chronic diseases remain leading contributors to global mortality, yet digital biomarkers offer transformative potential for personalized management. This systematic review evaluates the clinical performance ...
Toward a harmonized assessment of MRD by NGS: blinded pilot study of NGS assays by MPAACT consortium [0.03%]
基于NGS的MRD评估的一致性研究：MPAACT联盟的盲法试点研究
Vanessa Obourn,Shalaka Patel,Gonzalo Lopez et al.
Vanessa Obourn et al.
Background: Measurable residual disease (MRD) is a key prognostic factor in acute myeloid leukemia (AML). The Measurable residual disease Partnership and Alliance in Acute Myeloid Leukemia Clinical Treatment (MPAACT) Cons...
Expression levels of microRNA-550a-5p in patients with spinal metastases from non-small cell lung cancer [0.03%]
非小细胞肺癌脊柱转移患者中微核糖核酸-550a-5p的表达水平分析
Haifa Guo,Jiawei Li,Tao Li et al.
Haifa Guo et al.
Objective: This study aimed to investigate the expression levels of microRNA-550a-5p (miR-550a-5p) in patients with spinal metastases from non-small cell lung cancer (NSCLC) and to explore its clinical significance. ...
Epigenetic and genetic insights for tailored therapeutic strategies in multiple sclerosis [0.03%]
表观遗传和基因多发性硬化症的精准治疗策略研究进展
Aliakbar Mariki,Seyed Mohammad Mousavi,Kristi Anne Kohlmeier et al.
Aliakbar Mariki et al.
Multiple sclerosis (MS) is a complex neurological disorder with inflammation, demyelination, and neurodegeneration in the CNS. Disease-modifying therapies (DMTs) exist, but their efficacy is limited by MS's varied nature, highlighting the n...
Deciphering the multi-organ anti-fibrotic mechanisms of pirfenidone and nintedanib via network pharmacology [0.03%]
基于网络药理学的吡非尼酮和尼达尼布抗纤维化多靶点机制研究
Vishal S Patil,Chandragouda R Patil,Rohit Paul et al.
Vishal S Patil et al.
Background: Fibrosis is a systemic disorder driven by inflammation, immune imbalance, and extracellular matrix remodeling. Pirfenidone (PFD) and nintedanib (NTB), approved for idiopathic pulmonary fibrosis, may exert broa...
Association between microRNA 155 gene polymorphism and sporadic Parkinson's disease [0.03%]
微RNA155基因多态性与散发性帕金森病的关系
Siwei Luo,Jinrong Li,Yu Zhang et al.
Siwei Luo et al.
Introduction: The functional single nucleotide polymorphism (SNP) rs767649 in the miR-155 gene has been linked to other neurological disorders, but its association with sporadic Parkinson's disease (PD) remains unclear. ...