EXPRESS: Combination of GABA-derived short peptides and pregabalin in neuropathic pain: in vivo and in silico evaluation [0.03%]
GABA衍生物短肽与普瑞巴林联合用于神经病理性疼痛的体内和体外评价
Naira Adamyan,Arusyak Zhamharyan,Hakob Topchyan et al.
Naira Adamyan et al.
Neuropathic pain is a significant clinical issue due to the limited efficacy and adverse effects of existing therapies. The present study evaluated the analgesic effects of GABA-derived short peptides-pyroglutamylGABA, pyroglutamylGABA ethy...
EXPRESS: RIN1 inhibited TRPV1-dependent pain sensitization in a mouse model of bone cancer pain [0.03%]
RIN1抑制骨癌痛小鼠模型中的TRPV1依赖性痛觉过敏
Yue Zhang,Hai-Feng Jiang,Ya-Ni Guo et al.
Yue Zhang et al.
The Ras and Rab interactor 1 (RIN1) is a multifunctional signaling protein that has been implicated in the regulation of tumor cell migration and proliferation. Here we found that RIN1 was abundant in the dorsal root ganglia (DRG) neurons p...
EXPRESS: CYP gene variants show preliminary evidence of association with patient-reported outcomes in active-duty service members with chronic pain [0.03%]
痛风变异型与现役军人慢性疼痛患者报告结果相关性的初步证据
Nathan Tintle,Nathan Ryder,Jason Westra et al.
Nathan Tintle et al.
Chronic pain is highly prevalent among active-duty service members (ADSMs) and contributes to substantial physical, psychological, and social burden. Genetic factors are recognized as central to pain susceptibility and treatment response. W...
EXPRESS: Serum miR-145-5p as a Predictive Biomarker for Postoperative Pain after Percutaneous Kyphoplasty [0.03%]
血清miR-145-5p作为经皮椎体成形术后疼痛的预测性生物标志物的一项探索性研究
Min Fang,Juan Wang,Yongliang Zhu et al.
Min Fang et al.
Background: Thoracolumbar compression fractures are common in older adults. Percutaneous kyphoplasty (PKP) is a standard minimally invasive treatment, but 30% to 50% of patients still have persistent or inadequate pain re...
EXPRESS: Metformin Exhibits Analgesic Activity in Neuronal Cell Models and CFA-Induced Inflammatory Pain in Mice [0.03%]
研究快报：二甲双胍在神经细胞模型和CFA诱导的小鼠炎症痛中表现出镇痛活性
Thi-Chau-Loan Phan,Jui-Ting Chang,Chih-Hsiang Ma et al.
Thi-Chau-Loan Phan et al.
Inflammatory pain is mediated by complex interactions between immune signaling and sensory neurons, with prostaglandin E2-dependent pathways playing a central role in nociceptive sensitization. Metformin, a first-line antidiabetic drug, has...
Trevor Flanagan,Michael Caterina,Tatiana Muteba et al.
Trevor Flanagan et al.
Normal sensitivity of the Drosophila larval nociceptor requires the activity of the Wg/WNT signaling pathway. When the nociceptor expression of Wg/WNT co-receptor Arrow, Drosophila ortholog of LRP5/6, is impaired by RNA interference, the la...
EXPRESS: Mechanical Needling and Sterile Water Hydrodissection Modulate Nociception via Extracellular Matrix Perturbation and Ion Channels [0.03%]
基于细胞外基质和离子通道的针刺与无菌水介导的组织分离调节疼痛的作用及机制研究
Carl Chen,Areerat Suputtitada
Carl Chen
Background: Musculoskeletal disorders are increasingly recognized as conditions involving extracellular matrix dysregulation, characterized by fibrosis, calcification, fascial adhesions, and altered nociceptor signaling. ...
EXPRESS: Olfactory ensheathing cell transplantation targets macrophage extracellular traps and NKCC1 to alleviate pain after spinal cord injury [0.03%]
嗅觉包裹细胞移植靶向巨噬细胞胞外陷阱和NKCC1以缓解脊髓损伤后的疼痛
Honghui Lei,Tao Liu,Fangyong Wang et al.
Honghui Lei et al.
Spinal cord injury (SCI) triggers neuropathic pain through inflammatory secondary injury. Olfactory ensheathing cells (OECs) hold therapeutic promise, but their pain-relieving mechanisms are unclear. This study investigated whether OEC tran...
EXPRESS: Therapeutic Modulation of Pain-related Affective Disorders by Acupuncture: Mechanistic Review [0.03%]
针刺治疗疼痛相关情感障碍的机制研究综述
Hongchun Xiang,Yiwen Long,Siyi Wang et al.
Hongchun Xiang et al.
As a complex physiological and psychological phenomenon, pain has a wide impact on the quality of life of patients. Chronic pain represents one of the most challenging public health issues, and ensuring effective pain management is not only...
EXPRESS: Systemic curcumin administration mitigates neuropathic pain in a rat model of trigeminal neuralgia by suppressing TNF-α and pSTAT3 signaling [0.03%]
姜黄素通过抑制TNF-α和pSTAT3信号减轻三叉神经痛大鼠模型的神经病理性疼痛
Dara Sari Arini,Lutfi Putra Perdana,Jaime Fabillar Jr et al.
Dara Sari Arini et al.
Trigeminal neuralgia (TN) is a debilitating neuropathic facial pain disorder characterized by sudden, severe paroxysmal pain that markedly impairs quality of life. Although current pharmacological treatments provide pain relief, their adver...