Is there a role for pharmacogenetics in the treatment of sickle cell disease? [0.03%]
药物基因组学在镰状细胞病治疗中的作用探讨
Ambroise Wonkam
Ambroise Wonkam
CYP2D6 pharmacogenetic and oxycodone pharmacokinetic association study in pediatric surgical patients [0.03%]
儿科手术镇痛患者中CYP2D6药理基因与氧可酮药代动力学关联研究
Rajiv Balyan,Marc Mecoli,Raja Venkatasubramanian et al.
Rajiv Balyan et al.
Aim: Oxycodone is partly metabolized to the active metabolite oxymorphone by hepatic CYP2D6 in the liver. Significant genetic variability in CYP2D6 activity affects oxymorphone formation. This study aimed to associate CYP...
Clinical Trial
Pharmacogenomics. 2017 Mar;18(4):337-348. DOI:10.2217/pgs-2016-0183 2017
NFATC1 genotypes affect acute rejection and long-term graft function in cyclosporine-treated renal transplant recipients [0.03%]
环孢素治疗的肾移植受者的NFATC1基因型影响急性排斥和长期移植物功能
Qinxia Xu,Xiaoyan Qiu,Zheng Jiao et al.
Qinxia Xu et al.
Aim: To investigate the effects of SNPs in the cyclophilin A/calcineurin/nuclear factor of activated T-cells (NFATs) pathway genes (PPIA, PPP3CB, PPP3R1, NFATC1 and NFATC2) on cyclosporine (CsA) efficacy in renal transpla...
The need for precision medicine clinical trials in childhood asthma: rationale and design of the PUFFIN trial [0.03%]
儿童哮喘精准医疗临床试验的必要性：PUFFIN试验的设计与原理
Susanne Jh Vijverberg,Mariëlle W Pijnenburg,Anke M Hövels et al.
Susanne Jh Vijverberg et al.
A 'one-size fits all'-approach does not fit all pediatric asthma patients. Current evidence suggests that in children with persistent asthma, ADRB2 genotype-guided treatment can improve treatment outcomes, yet this evidence is mainly derive...
No impact of eight NTRK2 genetic polymorphisms on 6-month antidepressant efficacy in depressed patients [0.03%]
NTRK2基因多态性与抑郁症患者抗抑郁药疗效无关
Eric Deflesselle,Céline Verstuyft,Anne-Cécile Petit et al.
Eric Deflesselle et al.
Aim: NTRK2 is the main receptor of the brain derived neurotrophic factor, which is involved in antidepressant efficacy. We assessed the impact of eight NTRK2 SNPs pertaining to response and remission after antidepressant ...
Assessing feasibility of delivering pharmacogenetic testing in a community pharmacy setting [0.03%]
社区药房开展药物基因组检测的可行性评估
Susanne B Haga,Jivan Moaddeb,Rachel Mills et al.
Susanne B Haga et al.
Aim: To describe the rationale and design of a study evaluating the delivery of pharmacogenetic (PGx) testing in community pharmacies. Study rationale: Pharmacists have expressed interest in offering PGx testing; however,...
Randomized Controlled Trial
Pharmacogenomics. 2017 Mar;18(4):327-335. DOI:10.2217/pgs-2016-0175 2017
The role of pharmacogenetics in the new ESMO colorectal cancer guidelines [0.03%]
药物基因组学在新版ESMO结直肠癌诊疗指南中的作用
Marta Schirripa,Letizia Procaccio,Sara Lonardi et al.
Marta Schirripa et al.
A nationwide survey of pharmacists' perception of pharmacogenetics in the context of a clinical decision support system containing pharmacogenetics dosing recommendations [0.03%]
全国药剂师临床决策支持系统中包含药物基因分型剂量建议下的药物基因组学感知调查 khảo sát
Paul Cd Bank,Jesse J Swen,Henk-Jan Guchelaar
Paul Cd Bank
Aim: To benchmark Dutch pharmacists knowledge, experience and attitudes toward pharmacogenetics (PGx) with a specific focus on the effects of awareness of the Dutch Pharmacogenetics Working Group guidelines. ...