Pharmacogenetics in the treatment of pre-eclampsia: current findings, challenges and perspectives [0.03%]
先兆子痫的治疗中的药物基因组学：现有的研究发现、挑战和展望
Marcelo R Luizon,Ana Ct Palei,Ricardo C Cavalli et al.
Marcelo R Luizon et al.
Pre-eclampsia (PE) is defined as pregnancy-induced hypertension and proteinuria, and is a major cause of maternal and perinatal morbidity and mortality. A large subgroup of pregnant women with PE is nonresponsive to antihypertensive drugs, ...
Common genetic polymorphisms of adenosine A2A receptor do not influence response to regadenoson [0.03%]
腺苷A2A受体的常见基因多态性不影响regadenoson的反应效果
Mark Berlacher,Ronald Mastouri,Santosh Philips et al.
Mark Berlacher et al.
Aim: Hemodynamic response to regadenoson varies greatly, and underlying mechanisms for variability are poorly understood. We hypothesized that five common variants of adenosine A2A receptor (ADORA2A) are associated with a...
Replicated evidence for aminoacylase 3 and nephrin gene variations to predict antihypertensive drug responses [0.03%]
关于氨基酰酶3和肾素基因变异预测抗高血压药物反应的重复验证证据
Jenni M Rimpelä,Kimmo K Kontula,Frej Fyhrquist et al.
Jenni M Rimpelä et al.
Aim: To replicate the genome-wide associations of the antihypertensive effects of bisoprolol and losartan in GENRES, using the Finnish patients of LIFE study. ...
Randomized Controlled Trial
Pharmacogenomics. 2017 Apr;18(5):445-458. DOI:10.2217/pgs-2016-0204 2017
The influences of SLCO1B1 and ABCB1 genotypes on the pharmacokinetics of simvastatin, in relation to CYP3A4 inhibition [0.03%]
SLCO1B1和ABCB1基因多态性对CYP3A4抑制后辛伐他汀药动学的影响
Fen Jiang,Jong-Yeol Choi,Ju-Hyun Lee et al.
Fen Jiang et al.
Aim: To investigate the combined effects of SLCO1B1 and ABCB1 genotypes on the pharmacokinetics of simvastatin and its active metabolite simvastatin acid, in relation to CYP3A4 inhibition. ...
Clinical Trial
Pharmacogenomics. 2017 Apr;18(5):459-469. DOI:10.2217/pgs-2016-0199 2017
Impact of CYP2D6 genotype on amitriptyline efficacy for the treatment of diabetic peripheral neuropathy: a pilot study [0.03%]
CYP2D6基因多态性对阿米替林治疗糖尿病外周神经痛疗效影响的探索性研究
Mamoonah Chaudhry,Marco Alessandrini,Jacobus Rademan et al.
Mamoonah Chaudhry et al.
Aim: Therapy with low-dose amitriptyline is commonly used to treat painful diabetic peripheral neuropathy. There is a knowledge gap, however, regarding the role of variable CYP2D6-mediated drug metabolism and side effects...
Observational Study
Pharmacogenomics. 2017 Apr;18(5):433-443. DOI:10.2217/pgs-2016-0185 2017
Stijn Lw Koolen,Carin Cd Van der Rijt
Stijn Lw Koolen
Germline genetic predictors of aromatase inhibitor concentrations, estrogen suppression and drug efficacy and toxicity in breast cancer patients [0.03%]
用于预测乳腺癌患者芳香化酶抑制剂浓度、雌激素抑制和药物疗效及毒性的遗传学指标
Daniel L Hertz,N Lynn Henry,James M Rae
Daniel L Hertz
The third-generation aromatase inhibitors (AIs), anastrozole, letrozole and exemestane, are highly effective for the treatment of estrogen receptor-positive breast cancer in postmenopausal women. AIs inhibit the aromatase (CYP19A1)-mediated...
Institutional profile: University of Florida Health Personalized Medicine Program [0.03%]
佛罗里达大学健康个性化医学项目介绍
Larisa H Cavallari,Kristin W Weitzel,Amanda R Elsey et al.
Larisa H Cavallari et al.
The University of Florida (UF) Health Personalized Medicine Program launched in 2012 with CYP2C19 genotyping for clopidogrel response at UF Health Shands Hospital. We have since expanded CYP2C19 genotyping to UF Health Jacksonville and esta...
Stem cell-derived neurons in the development of targeted treatment for schizophrenia and bipolar disorder [0.03%]
基于干细胞神经元的精神分裂症和双向情感障碍的靶向治疗研究
Bradley Watmuff,Bangyan Liu,Rakesh Karmacharya
Bradley Watmuff
The recent advent of induced pluripotent stem cells has enabled the study of patient-specific and disease-related neurons in vitro and has facilitated new directions of inquiry into disease mechanisms. With these approaches, we now have the...
Deferasirox pharmacogenetic influence on pharmacokinetic, efficacy and toxicity in a cohort of pediatric patients [0.03%]
依托珠蛋白药理基因对药代动力学、疗效和毒性的一组儿科患者的影响
Sarah Allegra,Silvia De Francia,Jessica Cusato et al.
Sarah Allegra et al.
Aim: We aimed to evaluate the influence of genetic polymorphisms involved in deferasirox metabolism and transport on its pharmacokinetics and treatment toxicity, in a cohort of β-thalassaemic children. ...