From pharmacogenetics to imaging pharmacogenetics: elucidating mechanisms of antidepressant response [0.03%]
从药物基因组学研究到影像药理基因组学：阐明抗抑郁药的机制及应答反应
Eva J Brandl,Henrik Walter
Eva J Brandl
Pathway analysis to identify genetic variants associated with efficacy of adalimumab in rheumatoid arthritis [0.03%]
路径分析鉴别与类风湿关节炎adalimumab疗效相关的基因变异体
Frank Eektimmerman,Jesse J Swen,Stefan Böhringer et al.
Frank Eektimmerman et al.
Aim: About 30% of rheumatoid arthritis patients have no clinical benefit from TNF inhibitors. Genome-wide association (GWA) and candidate gene studies tested several putative genetic variants for TNF inhibitor efficacy wi...
Healthcare provider education to support integration of pharmacogenomics in practice: the eMERGE Network experience [0.03%]
eMERGE网络支持药理基因组学整合到实践的医疗保健人员教育体验
Carolyn R Rohrer Vitek,Noura S Abul-Husn,John J Connolly et al.
Carolyn R Rohrer Vitek et al.
Ten organizations within the Electronic Medical Records and Genomics Network developed programs to implement pharmacogenomic sequencing and clinical decision support into clinical settings. Recognizing the importance of informed prescribers...
Prenatal exposure to serotonin reuptake inhibitors and congenital heart anomalies: an exploratory pharmacogenetics study [0.03%]
胎儿接触5-羟色胺再摄取抑制剂与先天性心脏病的药理基因组学研究
Aizati N A Daud,Jorieke E H Bergman,Wilhelmina S Kerstjens-Frederikse et al.
Aizati N A Daud et al.
Aim: To explore the role of pharmacogenetics in determining the risk of congenital heart anomalies (CHA) with prenatal use of serotonin reuptake inhibitors. ...
MRP2/ABCC2 C1515Y polymorphism modulates exposure to lumefantrine during artemether-lumefantrine antimalarial therapy [0.03%]
药物基因组学：MRP2/ABCC2 C1515Y多态性调节 Artemether- Lumefantrine 治疗期间 Lucfectin 的暴露量
Karin Vos,Carlotta Lo Sciuto,Rita Piedade et al.
Karin Vos et al.
Aim: To investigate the potential involvement of the hepatic ATP-binding cassette transporters MRP2 and MDR1 in the disposition of lumefantrine (LUM) among patients with uncomplicated Plasmodium falciparum malaria. ...
MicroRNAs as a tool to aid stratification of colorectal cancer patients and to guide therapy [0.03%]
微小核糖核酸在结直肠癌患者分类及指导治疗中的作用
Matthew Goblirsch,Georg Richtig,Ondrej Slaby et al.
Matthew Goblirsch et al.
Colorectal cancer is a common type of malignant disease with high rates of morbidity and mortality. Although treatment options have been expanded over the last years, the mainstay of curative treatment remains surgical removal of the tumor-...
An enhancer haplotype may influence BCL11A expression levels and the response to hydroxyurea in β-thalassemia patients [0.03%]
一个增强子的基因型可能会影响BCL11A的表达水平以及β-地中海贫血患者的羟基脲治疗反应
Nahal Maroofi,Azita Azarkeivan,Soosan Banihashemi et al.
Nahal Maroofi et al.
Aim: To identify the BCL11A intron-2 enhancer linkage disequilibrium (LD) block, harboring two previously identified SNPs, associating with the hydroxyurea response in β-thalassemia patients and the functional significan...
CYP2D6 and CYP2C19 genotyping in psychiatric patients on psychotropic medication in the former Dutch Antilles [0.03%]
精神病患者在精神病药物治疗过程中的CYP2D6和CYP2C19基因分型研究（荷属安的列斯群岛）
Anne B Koopmans,David J Vinkers,Petra Ja Gelan et al.
Anne B Koopmans et al.
Aim: This study was aimed to asses the prevalence of CYP2D6 and CYP2C19 polymorphisms in psychiatric patients and in volunteers from Dutch caribbean origin. ...
David W Hein,Mark A Doll
David W Hein
Aim: Solithromycin is a new macrolide antibiotic for the potential treatment of bacterial pneumonia. Materials & methods: Solithromycin...
Ruowang Li,Dokyoon Kim,Marylyn D Ritchie
Ruowang Li
The scale and scope of pharmacogenomics research continues to expand as the cost and efficiency of molecular data generation techniques advance. These new technologies give rise to enormous opportunity for the identification of important ge...