Prior opioid exposure influences parents' sharing of their children's CYP2D6 research results [0.03%]
阿片类药物之前的暴露影响父母分享其孩子CYP2D6研究结果
Melanie F Myers,Xue Zhang,Brooke McLaughlin et al.
Melanie F Myers et al.
Aim: To determine parents' use of their children's CYP2D6 research result. We hypothesized that perceived utility, likelihood of sharing and actual sharing of results would differ between parents with children previously ...
Pharmacogenetics may influence the impact of inflammation on voriconazole trough concentrations [0.03%]
药物基因组学可能会影响炎症对伏立康唑谷浓度的影响
Elodie Gautier-Veyret,Sebastien Bailly,Xavier Fonrose et al.
Elodie Gautier-Veyret et al.
How pharmacogenetics modulates the inhibitory effects of inflammation on voriconazole trough concentration (Cmin) remains unknown. In 29 recipients of allogeneic hematopoietic stem cell transplantation retrospectively studied, both a geneti...
MTRR rs1801394 and its interaction with MTHFR rs1801133 in colorectal cancer: a case-control study and meta-analysis [0.03%]
中国结直肠癌病例对照研究及荟萃分析：MTRR基因rs1801394位点及其与MTHFR rs1801133的相互作用
Monir Sadat Haerian,Batoul Sadat Haerian,Saadat Molanaei et al.
Monir Sadat Haerian et al.
Aim: This study aims to evaluate the association between the MTRR rs1801394 alone or in interaction with the MTHFR rs1801133 and susceptibility to colorectal cancer (CRC) and its characteristics in Iranian population. Add...
Meta-Analysis
Pharmacogenomics. 2017 Jul;18(11):1075-1084. DOI:10.2217/pgs-2017-0030 2017
Pharmacogenetics of inflammatory bowel disease: a focus on Crohn's disease [0.03%]
炎症性肠病的药物遗传学：聚焦克罗恩病
Sara Rufini,Cinzia Ciccacci,Giuseppe Novelli et al.
Sara Rufini et al.
Crohn's disease is an inflammatory bowel disease showing a high heterogeneity in phenotype and a strong genetic component. The treatment is complex, due to different severity of clinical parameters and to the fact that therapies only permit...
Influence of common and rare genetic variation on warfarin dose among African-Americans and European-Americans using the exome array [0.03%]
利用外显子芯片分析常见和罕见遗传变异对非洲裔美国人和欧洲裔美国人的华法林剂量的影响
Nianjun Liu,Marguerite R Irvin,Degui Zhi et al.
Nianjun Liu et al.
Aim: We conducted a genome-wide association study using the Illumina Exome Array to identify coding SNPs that may explain additional warfarin dose variability. ...
Pharmacogenetics and the treatment of functional gastrointestinal disorders [0.03%]
药物基因组学与功能性胃肠病的治疗
Houssam Halawi,Michael Camilleri
Houssam Halawi
The diagnosis and management of functional gastrointestinal disorders (FGIDs) remain very challenging. In the era of precision medicine, it is important to individualize the treatment of these conditions by providing targeted and effective ...
The Ubiquitous Pharmacogenomics consortium: making effective treatment optimization accessible to every European citizen [0.03%]
泛药理基因组学（UPG）联盟：使有效的治疗优化惠及每一个欧洲公民
Lisanne En Manson,Cathelijne H van der Wouden,Jesse J Swen et al.
Lisanne En Manson et al.
Clinical effect of CYP2C9*5/*6 genotype on a patient's warfarin dose requirement [0.03%]
CYP2C9*5/*6基因型对患者华法林剂量需求的临床影响
Alison Lh Quinn,Ina Liko,James C Lee
Alison Lh Quinn
We describe a 38-year-old African-American female treated with warfarin for acute bilateral pulmonary emboli who is a carrier of two rare CYP2C9 variant alleles, *5 and *6, along with VKORC1 -1639GG and CYP4F2 433Val/Val genotypes. Warfarin...
Case Reports
Pharmacogenomics. 2017 Jul;18(11):1051-1057. DOI:10.2217/pgs-2017-0059 2017
Rationale and design of the multiethnic Pharmacogenomics in Childhood Asthma consortium [0.03%]
多族裔儿童哮喘药物基因组学联盟的研究目的和设计
Niloufar Farzan,Susanne J Vijverberg,Anand K Andiappan et al.
Niloufar Farzan et al.
Aim: International collaboration is needed to enable large-scale pharmacogenomics studies in childhood asthma. Here, we describe the design of the Pharmacogenomics in Childhood Asthma (PiCA) consortium. ...