Increased DNA methylation in the parvalbumin gene promoter is associated with methamphetamine dependence [0.03%]
帕值基因启动子DNA甲基化程度增加与冰毒成瘾相关
Siriluk Veerasakul,Paritat Watiktinkorn,Samur Thanoi et al.
Siriluk Veerasakul et al.
Aim: The parvalbumin (PV)-containing subgroup of GABAergic neurons is particularly affected in schizophrenia and animal models of psychosis, including after methamphetamine (METH) administration. We investigated whether M...
DNA methylation profiling opens a new phase in the search of targeted therapy against Ewing sarcoma [0.03%]
DNA甲基化谱分析开启了寻找尤因肉瘤靶向治疗的新纪元
Santi Rello-Varona,Oscar M Tirado
Santi Rello-Varona
The Pharmacogenetics Laboratory of the Department of Pharmacology and Toxicology at the American University of Beirut Faculty of Medicine [0.03%]
美国贝鲁特大学医学院药理学和毒理学系药物基因组学实验室
Nathalie K Zgheib
Nathalie K Zgheib
The pharmacogenetics (PGx) laboratory at the Department of Pharmacology and Toxicology at the American University of Beirut Faculty of Medicine was established in October 2007. Several projects on the genetic polymorphisms of drug metaboliz...
miRNA profiling for diagnosis, prognosis and stratification of cancer treatment in cholangiocarcinoma [0.03%]
用于肝内胆管癌诊断、预后及治疗分层的微小核糖核酸谱分析
Jisce R Puik,Laura L Meijer,Tessa Ys Le Large et al.
Jisce R Puik et al.
Cholangiocarcinoma (CCA) is a lethal malignancy originating from the biliary tract epithelium. Most patients are diagnosed at an advanced stage. Even after resection with curative intent, prognosis remains poor. Previous studies have report...
Reappraisal of the genetic diversity and pharmacogenetic assessment of CES1 [0.03%]
CESP1的遗传多样性和药物基因组学的再评价
Laura Ferrero-Miliani,Ditte Bjerre,Claus Stage et al.
Laura Ferrero-Miliani et al.
The CES1 gene encodes a hydrolase that metabolizes important drugs. Variants generated by exchange of segments with CES1P1 complicate genotyping of CES1. Using a highly specific procedure we examined DNA samples from 200 Caucasians and iden...
Sarah Jones
Sarah Jones
Falls: the adverse drug reaction of the elderly and the impact of pharmacogenetics [0.03%]
老年患者跌倒与药物不良反应以及药物基因组学的影响分析
Katja Susanne Just,Katharina Luise Schneider,Marlen Schurig et al.
Katja Susanne Just et al.
Falls is a frequent type of adverse drug reactions causing significant morbidity and mortality in the elderly. We reviewed, with which drugs the risk of falls is relevant and might depend on genomic variation. Pharmacogenetic variability ma...
María Isidoro-García,Almudena Sánchez-Martín,Asunción García-Sánchez et al.
María Isidoro-García et al.
Heterogeneity defines both the natural history of asthma as well as patient's response to treatment. Pharmacogenomics contribute to understand the genetic basis of drug response and thus to define new therapeutic targets or molecular biomar...
Using pharmacogenetics to prevent severe adverse reactions to capecitabine [0.03%]
药物基因组学在预防卡培他滨严重不良反应中的应用
Xandra García-González,Luis A López-Fernández
Xandra García-González
Prospect for immune checkpoint blockade: dynamic and comprehensive monitorings pave the way [0.03%]
免疫检查点抑制剂疗法展望：动态全程监测开启个体化医疗之门
Weili Wang,Jie Liu,Yijing He et al.
Weili Wang et al.
Immune checkpoint blockade, which releases the brake of the immune system to enhance anticancer immune response, stands out in the cancer immunotherapy field due to their remarkable and long-lasting effect. However, the overall response rat...