Pharmacogenomic markers associated with drug-induced QT prolongation: a systematic review [0.03%]
与药物引起QT延长有关的药理基因组标记物：系统性回顾
Marlene Schouby Bentestuen,Christian Noe Weis,Caroline Bækmann Jeppesen et al.
Marlene Schouby Bentestuen et al.
Aim: To systematically assess clinical studies involving patients undergoing drug therapy, comparing different genotypes to assess the relationship with changes in QT intervals, with no limitations on study design, settin...
Impact of a pharmacogenomics (PGx) clinic on patient satisfaction and PGx literacy [0.03%]
药效基因组学(PGx)诊所对患者满意度和PGx素养的影响
Amanda Massmann,Jordan Baye,Max Weaver et al.
Amanda Massmann et al.
Introduction: Genetic variants can impact medication response. The study of genetic variants on medications is called pharmacogenomics (PGx). Understanding PGx results can be difficult as results are reported differently ...
Lindy Maska,Roseann S Donnelly,Benjamin J Kerman et al.
Lindy Maska et al.
Aim: To assess patient perspectives following evaluation in a multidisciplinary pharmacogenomics clinic run by a clinical pharmacist, genetic counselor, and physician. ...
Reinterpretation of pharmacogenomic phenotypes after combinatorial psychiatric testing [0.03%]
精神科联合检测后对药物基因组表型的新解释
Michele Cung,John Loftus,Mark A Marzinke et al.
Michele Cung et al.
Aim: Providers can use combinatorial pharmacogenomic panels to aid psychiatric medication prescribing. Results are typically documented in static documents which list the genotype and predicted phenotype (interpretation)....
Treatment of extended RAS/ BRAF wild-type metastatic colorectal cancer with anti-EGFR antibody combinations [0.03%]
抗EGFR抗体组合治疗扩增的RAS/BRAF野生型转移性结直肠癌
Ioannis A Voutsadakis
Ioannis A Voutsadakis
Receptor tyrosine kinase pathways are frequently deregulated in cancer. Inhibiting these pathways with small molecule inhibitors or monoclonal antibodies has become a crucial addition to the therapeutic armamentarium in oncology. Since the ...
Posttransplantation diabetes mellitus (PTDM): pharmacological aspects and genetic predispositions [0.03%]
移植后糖尿病（PTDM）：药物作用和遗传易感性
Dorian Chastagner,Hélène Arnion,Clément Danthu et al.
Dorian Chastagner et al.
Posttransplantation diabetes mellitus (PTDM) is a form of diabetes developed after solid organ or stem cell transplantation. This condition shares physiopathological traits with type 2 diabetes, including insulin resistance and β-cells dys...
Pasquale Paribello,Ulker Isayeva,Claudia Pisanu et al.
Pasquale Paribello et al.
Aims: The present review explores the existing evidence on pharmacogenomic tests for prediction of lithium response in the treatment of bipolar disorder. We focused our research article on reports describing findings from...
Comparing the clinical utility of pharmacogenomic genotyping and next generation sequencing in a military health system adult medicine clinic [0.03%]
在军事卫生系统的成人内科诊所中比较药理基因组分型和下一代测序的临床实用性
David Saunders,Lydia D Hellwig,Austin Pagani et al.
David Saunders et al.
Introduction: Pharmacogenetic (PGx) screening is intended to optimize drug efficacy and reduce adverse drug reactions. Current screening options include genotyping assays for preselected PGx variants and broader next-gene...
TPMT and NUDT15 genotyping, TPMT enzyme activity and metabolite determination for thiopurines therapy: a reference laboratory experience [0.03%]
硫嘌呤治疗中 TPMT 和 NUDT15 基因分型，以及 TPMT 酶活性和代谢物测定：参考实验室经验
Sherin Shaaban,Brandon S Walker,Yuan Ji et al.
Sherin Shaaban et al.
Aim: To share the experience of a US national reference laboratory, offering genotyping for TPMT and NUDT15, TPMT enzyme phenotyping and detection of thiopurine metabolites. ...
Biomarkers for the prediction and monitoring of the antipsychotic/antidepressant-induced hepatotoxicity: study protocol [0.03%]
精神药物诱导肝毒性的预测和监测生物标志物研究方案
Zuzana Kilianova,Natalia Stollarova,Lenka Bies Pivackova et al.
Zuzana Kilianova et al.
Aim: This study is designed to address the connection between antidepressant and antipsychotic-induced hepatotoxicity with pharmacogenetic and epigenetic indicators, using a novel combined approach of CYP450 polymorphism ...