Patient ethnicity and the risk of immune-mediated adverse drug reactions [0.03%]
患者种族与免疫介导的药物不良反应风险关系研究
Ana Alfirevic
Ana Alfirevic
The μ-opioid receptor nonsynonymous variant 118A>G is associated with prolonged abstinence from heroin without agonist treatment [0.03%]
μ-阿片受体非 synonymous 基因变异 118A>G 与海洛因脱毒相关
Orna Levran,Einat Peles,Matthew Randesi et al.
Orna Levran et al.
Aim: This study assesses whether opioid-related gene variants contribute to reduced vulnerability to relapse to heroin in persons who are not treated with μ-opioid receptor agonist. ...
Epistatic interactions among CYP2C19*2, CYP3A4 and GSTP1 on the cyclophosphamide therapy in lupus nephritis patients [0.03%]
CYP2C19*2、CYP3A4和GSTP1在狼疮性肾炎患者环磷酰胺治疗中的上位效应交互作用研究
Konda Kumaraswami,Shiva Krishna Katkam,Amita Aggarwal et al.
Konda Kumaraswami et al.
Aim: To investigate the impact of genetic variants in CYP2C9, CYP2C19, CYP3A4, GSTT1, GSTM1 and GSTP1 on the efficacy of cyclophosphamide (CYC) therapy in patients with lupus nephritis. ...
Solomon M Adams,Yvette P Conley,Amy K Wagner et al.
Solomon M Adams et al.
Pharmacotherapy for traumatic brain injury (TBI) is focused on resuscitation, prevention of secondary injury, rehabilitation and recovery. Pharmacogenomics may play a role in TBI for predicting therapies for sedation, analgesia, seizure pre...
SLCO1A2, SLCO1B1 and SLCO2B1 polymorphisms influences chloroquine and primaquine treatment in Plasmodium vivax malaria [0.03%]
SLCO1A2，SLCO1B1和SLCO2B1多态性影响氯喹和伯氨喹治疗间日疟的效果
Vinicius A Sortica,Juliana D Lindenau,Maristela G Cunha et al.
Vinicius A Sortica et al.
Aim: The association of transporters gene polymorphisms with chloroquine/primaquine malaria treatment response was investigated in a Brazilian population. ...
Advancing psychiatric pharmacogenomics using drug development paradigms [0.03%]
利用药物研发范式推进精神疾病药理基因组学研究
Ryan M Smith
Ryan M Smith
Drugs used to treat psychiatric disorders, even when taken as directed, fail to provide adequate relief for a sizeable proportion of patients. Despite our advancements in understanding human genetics and development of high-throughput tools...
Influence of CYP3A and ABCB1 polymorphisms on cyclosporine concentrations in renal transplant recipients [0.03%]
CYP3A和ABCB1基因多态性对肾移植受者的环孢素血药浓度的影响
Bo Sun,Yankun Guo,Junwei Gao et al.
Bo Sun et al.
Aim: Cyclosporine is a substrate of CYP3A and ABCB1. This study examined the role of CYP3A and ABCB1 polymorphisms on cyclosporine pharmacokinetics in renal transplant recipients. ...
Pharmacoepigenomics of opiates and methadone maintenance treatment: current data and perspectives [0.03%]
阿片类药物与美沙酮维持治疗的药理表观遗传学：现有数据和未来展望
Cynthia Marie-Claire,Clément Jourdaine,Jean-Pierre Lépine et al.
Cynthia Marie-Claire et al.
Current treatments of opioid addiction include primarily maintenance medications such as methadone. Chronic exposure to opiate and/or long-lasting maintenance treatment induce modulations of gene expression in brain and peripheral tissues. ...
Nisha Nair,Anthony G Wilson,Anne Barton
Nisha Nair
Rheumatoid arthritis (RA) is a complex disease affecting approximately 0.5-1% of the population. While there are effective biologic therapies, in up to 40% of patients, disease activity remains inadequately controlled. Therefore, identifyin...
An epigenome-wide association study of inflammatory response to fenofibrate in the Genetics of Lipid Lowering Drugs and Diet Network [0.03%]
关于血脂调节药物与饮食网络研究中的苯扎贝特引起炎症反应的表观基因组相关性研究
Nabiha Yusuf,Bertha Hidalgo,Marguerite R Irvin et al.
Nabiha Yusuf et al.
Aim: Fenofibrate, a PPAR-α inhibitor used for treating dyslipidemia, has well-documented anti-inflammatory effects that vary between individuals. While DNA sequence variation explains some of the observed variability in ...