Population pharmacogenomics: impact on public health and drug development [0.03%]
人口药理基因组学对公共健康和新药开发的影响
George P Patrinos
George P Patrinos
Mara H Hutz,Carlos Rm Rieder
Mara H Hutz
The nuclear factor-kappa B pathway and response to treatment in breast cancer [0.03%]
核因子κB信号途径与乳腺癌治疗反应的关系
Yeon Hee Park
Yeon Hee Park
The nuclear factor-kappa B (NF-κB) pathway is known to contribute to critical signaling in cancer biology, including breast cancer, through promotion of proliferation, angiogenesis, metastasis, tumor progression, inflammation and cell surv...
Molecular network-selected pharmacogenomics in a case of bipolar spectrum disorder [0.03%]
双相障碍光谱系疾病中的分子网络选择药物基因组学
Stefano Fortinguerra,Alessandro Buriani,Vincenzo Sorrenti et al.
Stefano Fortinguerra et al.
Personal genomic analysis was used for molecular diagnosis and pharmacogenomics in a 53-year-old female suffering from alternating depressive and dysphoric episodes. A total of 52 genes and 108 SNPs were analyzed in the whole genome. Result...
Case Reports
Pharmacogenomics. 2017 Dec;18(18):1631-1642. DOI:10.2217/pgs-2017-0133 2017
Pharmacogenetics of drug-induced ototoxicity caused by aminoglycosides and cisplatin [0.03%]
氨基糖苷和顺铂所致药物性耳毒性的药理遗传学研究进展
Claudia Lanvers-Kaminsky,Giuliano Ciarimboli
Claudia Lanvers-Kaminsky
Aminoglycosides and the anticancer drug cisplatin can cause permanent hearing loss, which impacts patients' quality of life and results in considerable subsequent costs. Since patients' individual susceptibility to aminoglycoside- and cispl...
Impact of SNP-SNP interaction among ABCB1, ARRB2, DRD1 and OPRD1 on methadone dosage requirement in Han Chinese patients [0.03%]
ABCB1、ARRB2、DRD1和OPRD1基因多态性及其交互作用与中国汉族海洛因成瘾者美沙酮维持治疗剂量需求的关系
Rui Luo,Xingyuan Li,Shasha Qin et al.
Rui Luo et al.
Aim: To evaluate the potential association of the genetic polymorphisms in ABCB1, ARRB2, DRD1 and OPRD1 genes with methadone dosage requirement among Han Chinese opioid-dependent patients. ...
Yiannis Vasilopoulos
Yiannis Vasilopoulos
miR-509-3p promotes cisplatin-induced apoptosis in ovarian cancer cells through the regulation of anti-apoptotic genes [0.03%]
微RNA-509-3P通过调节抗凋亡基因促进顺铂诱导的卵巢癌细胞凋亡
Wei Chen,Jingjie Du,Xiaodi Li et al.
Wei Chen et al.
Aim: Previous observations have implicated miR-509-3p's ability in regulating cisplatin-triggered apoptosis in ovarian cancer. However, the underlying mechanisms were not fully understood. ...
Nuwan C Hettige,Ali Bani-Fatemi,Vincenzo De Luca
Nuwan C Hettige
Aim: Population stratification is a confounding factor in genetic association studies. Self-report measures, the most common method of collecting ethnicity, may be less reliable for psychiatric patients. This study aims t...
Jing-Ru Jhan,Eran R Andrechek
Jing-Ru Jhan
Breast cancer is composed of several well-recognized subtypes including estrogen receptor, progesterone receptor and HER2 triple-negative breast cancer (TNBC). Without available targeted therapy options, standard of care for TNBC remains ch...