Dyfrig A Hughes,Catrin O Plumpton
Dyfrig A Hughes
Pharmacogenetic tests are being used increasingly to prevent rare and potentially life-threatening adverse drug reactions. For many tests, however, cost-effectiveness is hard to demonstrate, and with the exception of a few cases, widespread...
Eva Dreussi,Fabrizio Ecca,Lucia Scarabel et al.
Eva Dreussi et al.
The immune system is a double-edged sword with regard to the prostate cancer (PCa) battle. Immunogenetics, the study of the potential role of immune-related polymorphisms, is taking its first steps in the treatment of this malignancy. This ...
Insights and barriers to clinical use of serotonin transporter pharmacogenetics in antidepressant therapy [0.03%]
血清素转运体药物基因组学在抗抑郁药治疗中的临床应用洞察与障碍分析
James M Stevenson
James M Stevenson
Effect of genetic polymorphisms in SREBF-SCAP pathway on therapeutic response to rosuvastatin in Saudi metabolic syndrome patients [0.03%]
遗传多态性对沙乌地代谢症候群患者rosuvastatin疗效的影响机制研究--透过SREBF-SCAP路径之探讨
Misbahuddin Mohd Rafeeq,Hamed Said Habib,Hussam Aly Sayed Murad et al.
Misbahuddin Mohd Rafeeq et al.
Aim: Genetic variants contribute to statins' therapeutic variability. SREBF-SCAP pathway is a key player in lipid homeostasis. Hence, effect of SREBF-SCAP polymorphisms on therapeutic response was studied. ...
Clinical Trial
Pharmacogenomics. 2018 Feb;19(3):185-196. DOI:10.2217/pgs-2017-0181 2018
Shangchen Xie,Wenjuan Ma,Qulian Guo et al.
Shangchen Xie et al.
General anesthesia is a state of unconsciousness, amnesia, analgesia and akinesia induced by drugs including opioids, hypnotic-sedative agents, muscle relaxants and antiemetics. Clinical and genetic factors are reported to influence the eff...
Attempted validation of 44 reported SNPs associated with tacrolimus troughs in a cohort of kidney allograft recipients [0.03%]
验证44个报道与他克莫司浓度相关的SNP在肾移植队列中有效性尝试
William S Oetting,Baolin Wu,David P Schladt et al.
William S Oetting et al.
Aim: Multiple genetic variants have been associated with variation in tacrolimus (TAC) trough concentrations. Unfortunately, additional studies do not confirm these associations, leading one to question if a reported asso...
Sarah Jones
Sarah Jones
Pharmacogenetic landscape of DPYD variants in south Asian populations by integration of genome-scale data [0.03%]
通过整合基因组规模数据集成的南亚人群DPYD变异的药物基因组学景观
Judith M Hariprakash,Shamsudheen K Vellarikkal,Pavithran Keechilat et al.
Judith M Hariprakash et al.
Aim: Adverse drug reactions to 5-Fluorouracil(5-FU) is frequent and largely attributable to genetic variations in the DPYD gene, a rate limiting enzyme that clears 5-FU. The study aims at understanding the pharmacogenetic...
Predictive role of NUDT15 variants on thiopurine-induced myelotoxicity in Asian inflammatory bowel disease patients [0.03%]
NUDT15变异在亚洲炎症性肠病患者硫嘌呤诱导的骨髓毒性中的预测作用
Natalia Sutiman,Sylvia Chen,Khoon Lin Ling et al.
Natalia Sutiman et al.
Background: Genetic variants of TPMT and NUDT15 have been reported to predict the inter-patient variability in response and toxicity profiles of patients receiving thiopurine therapy. However, the clinical utility of TPMT...
Dopamine gene variants in opioid addiction: comparison of dependent patients, nondependent users and healthy controls [0.03%]
多巴胺基因变异在阿片类药物成瘾中：依赖患者、非依赖使用者和健康对照者之间的比较研究
Matthew Randesi,Wim van den Brink,Orna Levran et al.
Matthew Randesi et al.
Aim: To determine whether specific dopaminergic system gene variants are associated with opioid dependence. Patients & methods: Subject...