Role of miRNAs in treatment response and toxicity of childhood acute lymphoblastic leukemia [0.03%]
微RNA在儿童急性淋巴细胞白血病治疗反应及毒副反应中的作用研究
Maitane Umerez,Susana Garcia-Obregon,Idoia Martin-Guerrero et al.
Maitane Umerez et al.
Childhood acute lymphoblastic leukemia survival rates have increased remarkably during last decades due, in part, to intensive treatment protocols. However, therapy resistance and toxicity are still two important barriers to survival. In th...
BCL11A and MDR1 expressions have prognostic impact in patients with acute myeloid leukemia treated with chemotherapy [0.03%]
化疗治疗的急性髓系白血病患者中BCL11A和MDR1表达具有预后价值
Guo Xutao,Shi PengCheng,Li Yin et al.
Guo Xutao et al.
Acute myeloid leukemia (AML) is a heterogeneous malignant disease. Many different genetic factors can affect a patient's clinical outcome. Aim: The aim of...
Detection of a rare CYP3A4 variant in a transplant patient characterized by a tacrolimus poor metabolizer phenotype [0.03%]
在移植患者中检测到一种罕见的CYP3A4变异体，该变异体表现出他克莫司贫代谢表型
Nuria Lloberas,Dennis A Hesselink,Ron Hn van Schaik et al.
Nuria Lloberas et al.
A validated CYP3A genotype classification system allows clustering patients into poor, intermediate and extensive metabolizer phenotypes. However, substantial overlap exists between the clusters. A rare CYP3A4 allele, named CYP3A4*20 (rs676...
Genetic variations in genes of the stress response pathway are associated with prolonged abstinence from heroin [0.03%]
应激反应通路基因多态性与海洛因戒断持续时间有关联
Orna Levran,Einat Peles,Matthew Randesi et al.
Orna Levran et al.
Aim: This study assesses whether genetic variants in stress-related genes are associated with prolonged abstinence from heroin in subjects that are not in long-term methadone treatment. ...
Novel approach for CES1 genotyping: integrating single nucleotide variants and structural variation [0.03%]
一种新颖的CES1基因分型方法：整合单核苷酸变异和结构变异
Ditte Bjerre,Henrik Berg Rasmussen,The Indices Consortium
Ditte Bjerre
Aim: Development of a specific procedure for genotyping of CES1A1 (CES1) and CES1A2, a hybrid of CES1A1 and the pseudogene CES1P1. Materials & methods: ...
Improving decision making on DPYD and UGT1A1*28 patients' profiling with an innovative reimbursement strategy [0.03%]
创新报销策略改善DPYD和UGT1A1*28患者检测决策
Rossana Roncato,Erika Cecchin,Giuseppe Toffoli
Rossana Roncato
The pharmacoepigenomics informatics pipeline defines a pathway of novel and known warfarin pharmacogenomics variants [0.03%]
药理表观遗传信息学管道定义了一个新的和已知的华法林药物基因组变异路径
Ari Allyn-Feuer,Alex Ade,Jasmine A Luzum et al.
Ari Allyn-Feuer et al.
Aim: 'Pharmacoepigenomics' methods informed by omics datasets and pre-existing knowledge have yielded discoveries in neuropsychiatric pharmacogenomics. Now we evaluate the generality of these methods by discovering an ext...
Potential therapeutic and economic value of risk-stratified treatment as initial treatment of multiple myeloma in Europe [0.03%]
欧洲作为多发性骨髓瘤初始治疗的风险分层治疗的潜在疗效和经济价值
Jennifer G Gaultney,Therese W Ng,Carin A Uyl-de Groot et al.
Jennifer G Gaultney et al.
Biomarkers associated with prognosis in multiple myeloma (MM) can be used to stratify patients into risk categories. An attractive alternative to uniform treatment (UT), risk-stratified treatment (RST) is proposed where high-risk patients r...
miRNAs as potential regulators of mTOR pathway in renal cell carcinoma [0.03%]
microRNA可能是肾细胞癌中mTOR信号通路的调节因子
Inês Nogueira,Francisca Dias,Ana Luísa Teixeira et al.
Inês Nogueira et al.
Renal cell carcinoma (RCC) is the most commonly occurring solid cancer of the adult kidney with the majority of RCC cases being detected accidentally. The most aggressive subtype is clear cell RCC (ccRCC). miRNAs, a family of small noncodin...
Impact of CYP2D6 on venlafaxine metabolism in Trinidadian patients with major depressive disorder [0.03%]
CYP2D6对特立尼达和多巴哥群岛居民抑郁症患者文拉法辛代谢的影响
Lazara Karelia Montané Jaime,Jeffrey Paul,Anthony Lalla et al.
Lazara Karelia Montané Jaime et al.
Aim: This study aimed to assess the impact of CYP2D6 and CYP2C19 variation on venlafaxine (VEN) at steady state in patients from Trinidad and Tobago of Indian and African descent with major depressive disorder. ...