From Homer and Hippocrates to modern personalized medicine: is there a role for pharmacoepigenomics in the treatment of alcohol addiction? [0.03%]
从荷马和希波克拉底到现代精准医疗：药物表观基因学在酒精成瘾治疗中的作用？
Georgia Ragia,Vangelis G Manolopoulos
Georgia Ragia
From the earliest times to the present, alcohol has evolved as part of life and culture. For most adults, moderate alcohol use is harmless, however, it lies at one end of a range that moves through alcohol abuse to alcohol addiction. Alcoho...
Are haplotypes in a single methotrexate pathway more predictive for response in rheumatoid arthritis than in different pathways? [0.03%]
单个甲氨蝶呤代谢途径的单倍型是否比不同代谢途径更能预测类风湿关节炎患者的疗效？
Tomas Soukup,Ivan Barvik,Jana Nekvindova et al.
Tomas Soukup et al.
Letter to the editor with respect to: Lima A, Bernardes M, Azevedo R, Seabra V and Medeiros R. Moving toward personalized medicine in rheumatoid arthritis: SNPs in methotrexate intracellular pathways are associated with methotrexate therape...
Changing vision: a review of pharmacogenetic studies for treatment response in age-related macular degeneration patients [0.03%]
治疗年龄相关性黄斑变性患者的药物基因组学研究进展及展望——治疗反应综述
Janan Arslan,Paul N Baird
Janan Arslan
Nonresponsiveness to age-related macular degeneration (AMD) treatments has become a growing concern in ophthalmology. Disparity among publications that have assessed pharmacogenetic (PGx) connections between AMD disease genes and treatments...
Kevin A Friede,Deepak Voora
Kevin A Friede
Pharmacogenetics and the treatment of chronic myeloid leukemia: how relevant clinically? An update [0.03%]
药理基因组学与慢性粒细胞白血病的治疗：临床意义更新及展望
Ravindran Ankathil,Husin Azlan,Abu Abdullah Dzarr et al.
Ravindran Ankathil et al.
Despite the excellent efficacy and improved clinical responses obtained with imatinib mesylate (IM), development of resistance in a significant proportion of chronic myeloid leukemia (CML) patients on IM therapy have emerged as a challengin...
Allelic frequencies of 60 pharmacogene variants assessed within a Burmese population residing in northeast Indiana, USA [0.03%]
美国中印州东北部缅甸人群中60种药物基因多态性的等位基因频率分布研究
Carrie C Hoefer,Emily J Brick,Ann Savariar et al.
Carrie C Hoefer et al.
Aim: The aim of this study was to investigate 60 SNPs pertaining to drug metabolism and pharmacodynamics in the Burmese refugee population in the Fort Wayne, Indiana area to better inform patient care. ...
SNPs affecting the clinical outcomes of regularly used immunosuppressants [0.03%]
影响常规免疫抑制剂临床疗效的基因多态性研究
Huan-Yu Meng,Zhao-Hui Luo,Bo Hu et al.
Huan-Yu Meng et al.
Recent studies have suggested that genomic diversity may play a key role in different clinical outcomes, and the importance of SNPs is becoming increasingly clear. In this article, we summarize the bioactivity of SNPs that may affect the se...
Genetic predictors of efficacy and toxicity of iguratimod in patients with rheumatoid arthritis [0.03%]
预测伊加鲁替莫治疗类风湿性关节炎疗效和毒性的遗传预测因素
Wenjing Xiao,Jian-Ping Guo,Chun Li et al.
Wenjing Xiao et al.
Iguratimod (IGU) is a novel disease-modifying anti-rheumatic drug (DMARD) in rheumatoid arthritis (RA). Like other DMARDs, IGU exhibited significant differences in effectiveness and safety. ...
A nationwide cross-sectional survey of pharmacy students on pharmacogenetic testing in The Netherlands [0.03%]
荷兰全国药学学生药物基因组检测横断面调查
Paul Cd Bank,Jesse J Swen,Henk-Jan Guchelaar
Paul Cd Bank
Aim: To benchmark knowledge and attitude of pharmacy students toward pharmacogenetics (PGx) and PGx testing and compare the results with practicing colleagues. ...
Patient perspectives following pharmacogenomics results disclosure in an integrated health system [0.03%]
患者全基因组测序结果的整合医疗体系反馈意见
Amy A Lemke,Peter J Hulick,Dyson T Wake et al.
Amy A Lemke et al.
Aim: To assess patient perceptions and utilization of pharmacogenomics (PGx) testing in an integrated community health system. Methods: ...