The pharmacogenetics of rosuvastatin and implications for treatment: a systematic review [0.03%]
罗苏伐他汀的药物基因组学及其对治疗的意义：系统性综述
Eva González-Iglesias,Jesús Novalbos,Francisco Abad-Santos
Eva González-Iglesias
Introduction: Rosuvastatin has become a good choice in the statin group because it has shown greater efficacy in reducing lipid levels than other statins, allowing patients to reach their therapeutic goal more quickly. To...
Genetic polymorphism associated with non-response to therapy in inflammatory bowel disease patients: a review [0.03%]
炎症性肠病患者治疗无反应相关的遗传多态性：综述
Thinagary Jegathesan,Syaratul Dalina Yusoff,Nor Asyikin Mohd Tahir
Thinagary Jegathesan
Inflammatory bowel disease (IBD) poses a major therapeutic challenge due to its chronic course and variable treatment responses. Genetic polymorphisms significantly influence drug efficacy, prompting this review to analyze their role in tre...
Opportunistic analysis of clinically actionable DPYD gene variants in a germline testing cohort in India [0.03%]
在印度遗传学检测队列中针对临床操作性DPYD基因变异体的机会主义分析
Rajdeep Raha,Rahul C Bhoyar,Ranendra Pratap Biswal et al.
Rajdeep Raha et al.
Aims: Dihydropyrimidine dehydrogenase (DPYD) plays a critical role in the metabolism of fluoropyrimidine-based chemotherapies such as 5-fluorouracil (5-FU), capecitabine, and tegafur. Genetic variants in DPYD can lead to ...
Pharmacogenetics of graft-versus-host disease: a path to personalized medicine [0.03%]
移植抗宿主病的药物基因组学——通向个性化医疗之路
Piotr Łacina,Jagoda Siemaszko,Katarzyna Bogunia-Kubik
Piotr Łacina
Graft-versus-host disease (GvHD) remains a significant complication of allogeneic hematopoietic stem cell transplantation (HSCT), contributing to increased morbidity and mortality. Thus, continuous development of novel prophylactic and ther...
Evidence level for pharmacogenetic testing in antidepressant treatment: a systematic review [0.03%]
抗抑郁药治疗药物基因检测的证据等级：系统性综述
Emytis Tavakoli,Leen Magarbeh,Samar Elsheikh et al.
Emytis Tavakoli et al.
Rationale: Preemptive pharmacogenetic (PGx) testing offers a promising approach to personalized antidepressant treatment by identifying genetic variations influencing drug metabolism. By focusing on CYP2D6 and CYP2C19 gen...
Predicting nifedipine responses in preterm labor: a risk score incorporating ABCG2 polymorphisms and clinical factors [0.03%]
一项结合ABCG2多态性和临床因素预测早产的硝地平反应的评分系统
Jungsun Kim,Ji Min Han,Jeong Yee et al.
Jungsun Kim et al.
Background: Nifedipine, a substrate of ATP-binding cassette superfamily G member 2 (ABCG2), is a tocolytic agent. This study aimed to construct a scoring system by exploring the association between ABCG2 polymorphisms and...
From bench to bedside: a spotlight on pharmacogenomics at Nemours Children's Health [0.03%]
从实验室到病床旁：了解纳尔逊儿童健康中心的药物基因组学
Kelsey J Cook,Nathan D Seligson,Benjamin Q Duong et al.
Kelsey J Cook et al.
Nemours Children's Health (NCH) is a large, multi-state pediatric health system in the United States with hospitals and outpatient locations across Delaware, New Jersey, Pennsylvania, and Florida. NCH has maintained consistent effort in pha...
Impact of ABCB1 gene polymorphism on clopidogrel plasma concentration and cardiovascular events in post-PCI patients [0.03%]
ABCB1基因多态性对PCI术后患者氯吡格雷血药浓度及心血管事件的影响
Abdur Razaq,Waheed Iqbal,Syed Tahir Shah et al.
Abdur Razaq et al.
Aim: This study investigated the impact of ABCB1 gene polymorphisms on clopidogrel absorption and therapeutic response by analyzing plasma levels of the clopidogrel carboxylic acid metabolite (CAM), and cardiovascular eve...
Variation in the ABC transporter genes and association with clinical outcomes in colorectal cancer: a brief review [0.03%]
结直肠癌中ABC转运蛋白基因多态性与临床结局的关联：综述
Zari Salahud Din,Maryam Saqib,Sehrish Zafar et al.
Zari Salahud Din et al.
Colorectal cancer is one of the most prevalent cancers worldwide. We have thus focused on studies on the association of genetic polymorphisms with treatment response and adverse effects in colorectal cancer patients. This review highlights ...
Genetic polymorphisms and adverse reactions to antituberculosis therapy [0.03%]
结核病治疗的药物不良反应与遗传多态性的关系研究进展
Hannah M Gunter,Phuti Choshi,Tafadzwa Chimbetete et al.
Hannah M Gunter et al.
Tuberculosis is the leading cause of death from a single infectious agent globally, with the highest burden in low-and middle-income countries. Successful treatment requires prolonged administration of multiple drugs. The increasing threat ...