Ana Sofia Patrão,Francisca Dias,Ana Luísa Teixeira et al.
Ana Sofia Patrão et al.
miRNAs are small noncoding RNA molecules that have a very important role in gene expression regulation and, therefore, in cell homeostasis. SNPs in certain miRNA-related genes have been shown to influence cancer risk and prognosis. miRNA ce...
Multi-ethnic SULT1A1 copy number profiling with multiplex ligation-dependent probe amplification [0.03%]
多民族人群SULT1A1基因拷贝数的多重连接依赖探针扩增技术分析
Raymon Vijzelaar,Mariana R Botton,Lisette Stolk et al.
Raymon Vijzelaar et al.
Aim: To develop a SULT1A1 multiplex ligation-dependent probe amplification assay and to investigate multi-ethnic copy number variant frequencies. Methods:...
RICTOR gene amplification is correlated with metastasis and therapeutic resistance in triple-negative breast cancer [0.03%]
里克汀基因扩增与三阴性乳腺癌转移和治疗抵抗有关
Said El Shamieh,Fatima Saleh,Salim Moussa et al.
Said El Shamieh et al.
Triple-negative breast cancer (TNBC) is characterized by its aggressive behavior, metastasis and lack of targeted therapies. Herein, we discuss the clinical, histopathological and genetic profile of a woman diagnosed with TNBC. Since the pa...
Case Reports
Pharmacogenomics. 2018 Jun 1;19(9):757-760. DOI:10.2217/pgs-2018-0019 2018
Systematic evaluation of clinical practice guidelines for pharmacogenomics [0.03%]
药理基因组学临床实践指南的系统评估
Robert D Beckett,David F Kisor,Thomas Smith et al.
Robert D Beckett et al.
Aim: To systematically assess methodological quality of pharmacogenomics clinical practice guidelines. Methods: Guidelines published th...
A gene variant near ATM affects the response to metformin and metformin plasma levels: a post hoc analysis of an RCT [0.03%]
ATM基因变异体影响二甲双胍的反应及二甲双胍的血药浓度：一项基于随机试验的事后分析结果
Mattijs Out,Matthijs L Becker,Ron H van Schaik et al.
Mattijs Out et al.
Aim: To determine the influence of polymorphisms on the effects of metformin on HbA1c, daily dose of insulin and metformin plasma concentration. Methods: In a post hoc analysis of a 4.3 year placebo-controlled randomized ...
Clinical Trial
Pharmacogenomics. 2018 Jun 1;19(8):715-726. DOI:10.2217/pgs-2018-0010 2018
Pharmacogenomics in liver transplantation: testing the recipient and the ex-vivo donor liver [0.03%]
肝脏移植中的药物基因组学：对受体和体外供肝进行检测
David F Kisor,Adam S Bodzin
David F Kisor
Vitamin D pathway gene polymorphisms affecting daclatasvir plasma concentration at 2 weeks and 1 month of therapy [0.03%]
维生素D途径基因多态性影响达克拉特韦血药浓度的研究
Jessica Cusato,Amedeo De Nicolò,Lucio Boglione et al.
Jessica Cusato et al.
Aim: Vitamin D (VD) influences genetic expression through its receptor (VDR). VD pathway gene polymorphisms seem to influence antiviral drug pharmacokinetics and therapeutic outcome/toxicity. We investigated the associati...
The impact of OPRM1's genetic polymorphisms on methadone maintenance treatment in opioid addicts: a systematic review [0.03%]
OPRM1基因多态性对阿片类物质依赖者美沙酮维持治疗效果影响的系统评价
Bilel Oueslati,Olfa Moula,Rim Ghachem
Bilel Oueslati
Aim: Methadone is a long-acting opioid receptor agonist. It is prescribed to patients with opioid-related use disorders. The OPRM1 gene encodes for methadone's main receptor. It appears that polymorphisms in OPRM1 may aff...
Variants in genes coding for glutathione S-transferases and asthma outcomes in children [0.03%]
谷胱甘肽S-转移酶基因多态性与儿童哮喘发病的关系研究
Steve Turner,Ben Francis,Nuha Wani et al.
Steve Turner et al.
Our hypothesis was that children with mutations in genes coding for glutathione S-transferases (GST) have worse asthma outcomes compared with children with active type genotype. Data were collected in five populations. The rs1695 single nuc...
EGFR-TKIs in non-small-cell lung cancer: focus on clinical pharmacology and mechanisms of resistance [0.03%]
非小细胞肺癌中的表皮生长因子受体酪氨酸激酶抑制剂：临床药理学和耐药机制的新进展
Stefano Fogli,Beatrice Polini,Marzia Del Re et al.
Stefano Fogli et al.
The clinical introduction of EGFR-TKIs within the oncologic armamentarium has changed the therapeutic landscape of non-small-cell lung cancer (NSCLC) creating widespread expectations both in patients and clinicians. However, several gaps in...