Proton-coupled folate transporter as a biomarker of outcome to treatment for pleural mesothelioma [0.03%]
质子偶联叶酸转运蛋白作为胸膜间皮瘤治疗预后的生物标志物
Giovanna Li Petri,Stella Cascioferro,Barbara Parrino et al.
Giovanna Li Petri et al.
Implication of critical pharmacokinetic gene variants on therapeutic response to metformin in Type 2 diabetes [0.03%]
线粒体基因多态性对中国汉族人群二甲双胍治疗反应的影响研究
Nagaraja M Phani,Manik Vohra,Ananth Kakar et al.
Nagaraja M Phani et al.
Aim: Metformin, an oral hypoglycemic drug is the first line of treatment for Type 2 diabetes individuals. We studied the effect of critical gene single nucleotide polymorphisms on the glucose lowering effect of metformin....
Prolactin levels: sex differences in the effects of risperidone, 9-hydroxyrisperidone levels, CYP2D6 and ABCB1 variants [0.03%]
培高利特水平：利培酮的性别差异效应、9-羟基利培酮水平、CYP2D6和ABCB1变异体的影响
Georgios Schoretsanitis,Jose de Leon,Francisco J Diaz
Georgios Schoretsanitis
Aim: The role of sex on the association of plasma prolactin levels with risperidone (R) and 9-hydroxyrisperidone (9-OHR) concentrations is investigated. M...
From genes to treatments: a systematic review of the pharmacogenetics in smoking cessation [0.03%]
从基因到治疗：系统评价吸烟戒断的药物基因组学研究进展
Naji C Salloum,Erica L F Buchalter,Swati Chanani et al.
Naji C Salloum et al.
Smoking cessation treatment outcomes may be heavily influenced by genetic variations among smokers. Therefore, identifying specific variants that affect response to different pharmacotherapies is of major interest to the field. In the curre...
Codeine-induced acute generalized exanthematous pustulosis without IL36RN mutations [0.03%]
无IL36RN基因突变的可卡因诱导急性一般化脓性皮肤病病例
Zohra Chadli,Chayma Ladhari,Emna Kerkeni et al.
Zohra Chadli et al.
Recent studies have suggested an association between mutations in the IL-36RN gene and the onset of pustular generalized. In the literature, only one case of acute generalized exanthematous pustulosis (AGEP) induced by codeine in a patient ...
Case Reports
Pharmacogenomics. 2018 Jul 1;19(11):889-893. DOI:10.2217/pgs-2017-0200 2018
Standardization can accelerate the adoption of pharmacogenomics: current status and the path forward [0.03%]
标准化可以加速药物基因组学的采用：现状及未来之路
Kelly E Caudle,Nicholas J Keeling,Teri E Klein et al.
Kelly E Caudle et al.
Successfully implementing pharmacogenomics into routine clinical practice requires an efficient process to order genetic tests and report the results to clinicians and patients. Lack of standardized approaches and terminology in clinical la...
Pharmacogenetic of voriconazole antifungal agent in pediatric patients [0.03%]
儿科患者抗真菌药物伏立康唑的药物基因组学研究进展
Sarah Allegra,Giovanna Fatiguso,Silvia De Francia et al.
Sarah Allegra et al.
Aim: We explored the role of SNPs within the SLCO1B3, SLCO1B1, SLC22A6, ABCB1, ABCG2, SLCO3A1, CYP2C19, ABCC2, SLC22A1, ABCB11 and NR1I2 genes on voriconazole pharmacokinetics. ...
Preventing the exacerbation of health disparities by iatrogenic pharmacogenomic applications: lessons from warfarin [0.03%]
警惕医源性药物基因组应用对健康差异的加剧作用——来自华法林应用的启示
Jorge Duconge,Gualberto Ruaño
Jorge Duconge
Projected impact of a multigene pharmacogenetic test to optimize medication prescribing in cardiovascular patients [0.03%]
多基因药物基因组检测在心血管疾病患者中的应用效果预测研究
Olivia M Dong,Amy Li,Oscar Suzuki et al.
Olivia M Dong et al.
Aim: To determine the projected impact of a multigene pharmacogenetic (PGx) test on medication prescribing. Materials & methods: A retr...
Computational functional genomics-based approaches in analgesic drug discovery and repurposing [0.03%]
基于计算功能基因组学的镇痛药物发现与再定位方法学研究
Catharina Lippmann,Dario Kringel,Alfred Ultsch et al.
Catharina Lippmann et al.
Persistent pain is a major healthcare problem affecting a fifth of adults worldwide with still limited treatment options. The search for new analgesics increasingly includes the novel research area of functional genomics, which combines dat...