Effect of CYP2C19 and CYP2D6 genotype on tamoxifen treatment outcome indicates endogenous and exogenous interplay [0.03%]
CYP2C19和CYP2D6基因型对他莫昔芬治疗效果的影响表明内源与外源的相互作用
Sarah Sim,John Lövrot,Jonatan D Lindh et al.
Sarah Sim et al.
Aim: We investigated the interaction of CYP2C19 and CYP2D6 genotype on clinical outcome in tamoxifen-treated breast cancer patients. Materials & methods: ...
Charity Nofziger,Markus Paulmichl
Charity Nofziger
Beta-1,4-galactosyltransferase 2 c.909C>T gene variant is predictive of on-clopidogrel platelet reactivity [0.03%]
β-1,4-半乳糖基转移酶2基因c.909C＞T多态性与氯吡格雷抵抗的关系研究
Nicolas Pallet,Tiphaine Belleville-Rolland,Anne Savalle et al.
Nicolas Pallet et al.
CYP2C19 genotype influences clopidogrel response but only accounts for a small part of the variability in platelet reactivity. Recently, exome sequencing identified a variant of the gene encoding B4GALT2 as a potential candidate implicated ...
Observational Study
Pharmacogenomics. 2018 Aug 1;19(12):937-945. DOI:10.2217/pgs-2018-0057 2018
Genetic polymorphisms of CYP2S1, CYP2J2 and CYP2R1 genes in three Chinese populations: Han, Tibetan and Uighur [0.03%]
汉族、藏族和维吾尔族人群CYP2S1、CYP2J2及CYP2R1基因多态性分布研究
Xing Kang,Hailong Shi,Lirong Zhang et al.
Xing Kang et al.
Aim: Cytochrome P450 enzymes CYP2S1, CYP2J2 and CYP2R1 are of interest due to their unknown enzymatic function and disease-specific expression property. The aim of this study was to investigate the genetic variations of C...
CYP2D6 genotype analysis of a Thai population: platform comparison [0.03%]
泰国人群的细胞色素P450 2D6基因分型分析：平台比较
Monpat Chamnanphon,Andrea Gaedigk,Natchaya Vanwong et al.
Monpat Chamnanphon et al.
The highly polymorphic CYP2D6 gene locus leads to a wide range of enzyme activity. Since there are limited data for Thai, the major aim was to investigate CYP2D6 genetic variation in a large Thai population (n = 920). CYP2D6 genotyping was ...
Comparative Study
Pharmacogenomics. 2018 Aug 1;19(12):947-960. DOI:10.2217/pgs-2018-0075 2018
Pharmacogenetics and the treatment of HIV-/HCV-coinfected patients [0.03%]
药物基因组学与HIV-/HCV-合并感染患者的治疗
Mario Frias,Antonio Rivero-Juárez,Pedro López-López et al.
Mario Frias et al.
This review will summarize the role of pharmacogenetics in the natural history of hepatitis C, particularly in patients with HIV/HCV and will take the perspective of pharmacogenetics and its influence on the response to antiviral therapy an...
Kevin M Huang,Shuiying Hu,Alex Sparreboom
Kevin M Huang
The solute carrier superfamily comprises of uptake transporters that can contribute to the absorption and elimination of a broad array of clinically important drugs. Recent studies have suggested that the tissue-specific expression of these...
CYP3A5 and ABCB1 polymorphisms in living donors do not impact clinical outcome after kidney transplantation [0.03%]
活体供者的CYP3A5和ABCB1多态性不会影响肾移植的临床结果
Lin Yang,Brenda Cm de Winter,Ron Hn van Schaik et al.
Lin Yang et al.
Aim: To investigate the association between donor CYP3A5 and ABCB1 polymorphisms and tacrolimus (Tac)-induced nephrotoxicity and renal function in kidney transplant recipients. ...
Long noncoding RNA signature in predicting metastasis following tamoxifen treatment for ER-positive breast cancer [0.03%]
长链非编码RNA在雌激素受体阳性乳腺癌他莫昔芬治疗后复发转移中的预后价值及机制研究
Rong Liu,Rong Hu,Wei Zhang et al.
Rong Liu et al.
Aim: We aimed to develop a long noncoding RNA (lncRNA) expression signature that can predict response to tamoxifen. Materials & methods: ...
Single-tube multiplex real-time PCR assay for rapid and reliable detection of HLA-A*31:01 allele [0.03%]
用于快速准确检测HLA-A*31:01等位基因的多重实时定量PCR方法研究
Tingting Zhang,Ying Xiao,Yanxia Wang et al.
Tingting Zhang et al.
Aim: HLA-A*31:01 has been associated with carbamazepine-induced hypersensitivity reactions. HLA-A*31:01 genetic testing is recommended before the initiation of carbamazepine therapy. ...