Clinical pharmacogenomics of carvedilol: the stereo-selective metabolism angle [0.03%]
卡维地洛的临床药物基因组学：立体选择性代谢角度分析
Barbara M Parker,Sara L Rogers,Anastasios Lymperopoulos
Barbara M Parker
Hypersensitivity reactions to nonsteroidal anti-inflammatory drugs: an update on pharmacogenetics studies [0.03%]
非甾体抗炎药超敏反应的药物基因组学研究进展
María Del Carmen Plaza-Serón,Elena García-Martín,Jose Augusto Agúndez et al.
María Del Carmen Plaza-Serón et al.
Nonsteroidal anti-inflammatory drugs are the medications most frequently involved in hypersensitivity reactions to drugs. These can be induced by specific immunological and nonimmunological mechanisms, being the latter the most frequent. Th...
Glucocorticoid receptor single nucleotide polymorphisms are associated with acute crisis pain in sickle cell disease [0.03%]
糖皮质激素受体单核苷酸多态性与镰状细胞病急性危象痛的关系
Ellie H Jhun,Nilanjana Sadhu,Yingwei Yao et al.
Ellie H Jhun et al.
Aim: Pain in sickle cell disease patients is heterogeneous and genetic polymorphisms may predispose an individual to varied vulnerability to painful events. We studied the association of SNPs in the glucocorticoid recepto...
Human liver spheroids in chemically defined conditions for studies of gene-drug, drug-drug and disease-drug interactions [0.03%]
人源化肝球体在化学定义培养基中用于基因-药物、药物-药物及疾病-药物相互作用的研究
Magnus Ingelman-Sundberg,Volker M Lauschke
Magnus Ingelman-Sundberg
Recent phenotypically and functionally relevant human hepatic in vitro systems combine the ability to preserve interindividual molecular differences between patients' livers in culture with the accessibility and high-throughput compatibilit...
Genomic markers of resistance to targeted treatments in gastric cancer: potential new treatment strategies [0.03%]
胃癌针对治疗抵抗的基因标志物：潜在的新治疗策略
Alessandra Raimondi,Federico Nichetti,Giorgia Peverelli et al.
Alessandra Raimondi et al.
Gastric cancer is a highly heterogeneous disease, displaying a complex genomic landscape and an unfavorable outcome with standard therapies. Based on distinctive genomic alterations, novel targeted agents have been developed with the aim of...
Tacrolimus population pharmacokinetic models according to CYP3A5/CYP3A4/POR genotypes in Chinese Han renal transplant patients [0.03%]
汉族肾移植患者细胞色素P450酶(CYP3A5/CYP3A4/POR基因型的他克莫司药物代谢动力学模型研究
Wan Zhu,Ling Xue,Hongwei Peng et al.
Wan Zhu et al.
Aim: To develop a population pharmacokinetic (PK) model of tacrolimus in Chinese Han renal transplant population and establish the influence of different covariates (especially different CYP3A5/3A4/POR genotype) on PK pro...
Marin M Jukic,Volker M Lauschke,Takahiro Saito et al.
Marin M Jukic et al.
The ultrarapid CYP2D6 metabolizer (UM) phenotype is caused by CYP2D6 gene duplications in some, but not all, UM individuals. CYP2D6 and the adjacent pseudogene CYP2D7 are highly homologous; however, CYP2D7 harbors a premature stop codon, wh...
Clinical outcomes of CYP2C19 genotype-guided antiplatelet therapy: existing evidence and future directions [0.03%]
基质金属蛋白酶-19基因分型指导的抗血小板治疗临床疗效：现有证据及未来研究方向
Melissa D Klein,Craig R Lee,George A Stouffer
Melissa D Klein
It is well established that the CYP2C19 nonfunctional *2 and *3 polymorphisms impair the bioactivation and antiplatelet effects of clopidogrel, and increase the risk of adverse cardiovascular events following percutaneous coronary intervent...
Pharmacogenetics and cognitive symptoms in schizophrenia patients treated with antipsychotics [0.03%]
抗精神病药治疗的精神分裂症患者的药物基因和认知症状之间的关系
Richard Musil,Ilja Spellmann
Richard Musil
Association of ABCC2 polymorphism and gender with high-density lipoprotein cholesterol response to simvastatin [0.03%]
ABCC2基因多态性和性别对辛伐他汀升高高密度脂蛋白胆固醇疗效的影响及其机制研究
Na Liu,Guihua Yang,Mei Hu et al.
Na Liu et al.
Aim: The clinical benefits of lipid-lowering therapy with statins are widely recognized. However, the lipid-lowering efficacy of statins shows significant differences between individuals. ABCC2 has been demonstrated to co...
Observational Study
Pharmacogenomics. 2018 Sep 1;19(14):1125-1132. DOI:10.2217/pgs-2018-0084 2018