Pharmacogenetic guidelines and decision support tools for depression treatment: application to late-life [0.03%]
抑郁症的药理遗传学指南和决策支持工具在晚发抑郁症中的应用
Donald D Chang,Harris A Eyreeuro,Ryan Abbott et al.
Donald D Chang et al.
Late-life depression (LLD) is a major depressive disorder that affects someone after the age of 60 years. LLD is frequently associated with inadequate response and remission from antidepressants, in addition to polypharmacy. Pharmacogenetic...
Pharmacogenetics to prevent heparin-induced thrombocytopenia: what do we know? [0.03%]
药学遗传学预防肝素诱导的血小板减少症：我们了解多少？
Jason H Karnes
Jason H Karnes
Heparin-induced thrombocytopenia (HIT) is a life-threatening, immune-mediated adverse reaction to heparin anticoagulants. The inability to predict HIT represents a considerable liability associated with heparin administration. Genetic studi...
Pharmacogenetic relevance of endothelial nitric oxide synthase polymorphisms and gene interactions [0.03%]
内皮型一氧化氮合酶多态性和基因交互作用的药理遗传学意义
Marcelo R Luizon,Daniela A Pereira,Jose E Tanus-Santos
Marcelo R Luizon
Endothelial nitric oxide synthase (NOS3) is a key enzyme responsible for nitric oxide (NO) generation in the vascular endothelium. Endothelial dysfunction is characterized by reduced NO production, and is a hallmark of cardiovascular diseas...
Analysis of outpatient HER2 testing in New York state using the statewide planning and research cooperative system [0.03%]
基于纽约州全省规划与研究协作系统对纽约州门诊HER2检测的分析
Erik Hefti,David M Jacobs,Khyatiben Rana et al.
Erik Hefti et al.
Aim: HER2 testing is necessary in the context of therapy with trastuzumab, pertuzumab, lapatinib and neratinib. There is a paucity of reports describing the utilization rates of HER2 testing in large outpatient population...
Amalio Telenti
Amalio Telenti
Nyarai Desiree Soko,Collen Masimirembwa,Collet Dandara
Nyarai Desiree Soko
No association between G1359A CB1 polymorphisms and pain in young northeastern Mexicans [0.03%]
年轻东北墨西哥人中G1359A CB1多态性与疼痛无关
Ismael A Rodríguez-Rodríguez,Karla A Fernandez-Quiroga,Pilar Dc Morales-San Claudio et al.
Ismael A Rodríguez-Rodríguez et al.
Aim: Recent studies show an association between the endocannabinoid system and pain. In this study, we analyzed the association between two CNR1 gene polymorphisms and pain perception in a northeast Mexican population. ...
Breakthrough cancer genome analysis in time and space: novel oncotargets and early drug development [0.03%]
时间和空间下的癌症基因组分析突破：新的抗癌药物标靶及早期开发
Ioannis D Kyrochristos,Demosthenes E Ziogas,Persefoni Antoniou et al.
Ioannis D Kyrochristos et al.
Novel motif of variable number of tandem repeats in TPMT promoter region and evolutionary association of variable number of tandem repeats with TPMT*3 alleles [0.03%]
TPMT启动子区域新颖的串联重复序列模式及其与TPMT*3等位基因进化关联性研究
Dunja Urbančič,Alenka Šmid,Gabriele Stocco et al.
Dunja Urbančič et al.
Aim: SNPs in the gene for TPMT exemplify one of the most successful translations of pharmacogenomics into clinical practice. This study explains the correlation between common SNPs and variable number of tandem repeats (V...
Lynn G Dressler,Gillian C Bell,Karl D Ruch et al.
Lynn G Dressler et al.
The implementation of a de novo personalized medicine program in a rural community health system serving an underserved population is described. Focusing on the safe use of drugs impacted by genetic variations in the non-oncology setting, w...