Biomarkers and pathways of chemoresistance and chemosensitivity for personalized treatment of pancreatic adenocarcinoma [0.03%]
胰腺导管腺癌化疗耐药与敏感的生物标志物和信号通路：个体化治疗的新策略
Tomas Zemanek,Bohuslav Melichar,Martin Lovecek et al.
Tomas Zemanek et al.
Pancreatic carcinoma is usually diagnosed late when treatment options are limited and is considered a chemo-resistant malignancy. However, early stage, good performance status and specific patient subgroup are thought to have a more favorab...
Pharmacogenetic tests and depressive symptom remission: a meta-analysis of randomized controlled trials [0.03%]
药代遗传学检测与抑郁症缓解症状：随机对照试验的meta分析研究
Chad A Bousman,Katarina Arandjelovic,Serafino G Mancuso et al.
Chad A Bousman et al.
Aim: To conducted a systematic review and meta-analysis of prospective, randomized controlled trials (RCTs) that examined pharmacogenetic-guided decision support tools (DSTs) relevant to depressive symptom remission in ma...
Meta-Analysis
Pharmacogenomics. 2019 Jan;20(1):37-47. DOI:10.2217/pgs-2018-0142 2019
Prevalence of pharmacogenomic variants affecting the efficacy of clopidogrel therapy in the Hispanic Community Health Study/Study of Latinos cohort [0.03%]
Hispanics社区健康研究/拉丁裔研究队列中影响氯吡格雷疗效的药物基因组变异的流行率
Kyle Melin,Jee-Young Moon,Qibin Qi et al.
Kyle Melin et al.
Purpose: Although clopidogrel is the most widely used oral P2Y12 receptor antagonist, up to 10% of acute coronary syndrome patients treated with clopidogrel will experience a recurrent myocardial infarction and 2-3% will ...
Patients carrying CYP2C8*3 have shorter systemic paclitaxel exposure [0.03%]
携带CYP2C8*3的患者的全身紫杉醇暴露时间更短
Lauren A Marcath,Kelley M Kidwell,Adam C Robinson et al.
Lauren A Marcath et al.
Aim: First, evaluate if patients carrying putatively diminished activity CYP2C8 genotype have longer paclitaxel exposure (e.g., time above threshold concentration of 0.05 μM [Tc >0.05]). Second, screen additional pharmac...
Prolonged clonazepam-induced withdrawal symptoms in an NAT2 ultraslow acetylator [0.03%]
NAT2慢代谢引起的氯硝西泮延长停药症状病例报告
Teresa T Ho,Sheeba Varghese Gupta,Amarilis Sanchez-Valle
Teresa T Ho
Clonazepam undergoes nitroreduction to 7-amino-clonazepam via CYP3A4/5, followed by acetylation to 7-acetamido-clonazepam via NAT2 enzyme. While no pharmacological activity is attributed to the metabolites of clonazepam, 7-amino-clonazepam ...
Case Reports
Pharmacogenomics. 2019 Jan;20(2):69-73. DOI:10.2217/pgs-2018-0145 2019
The emerging role of liquid biopsy in diagnosis, prognosis and treatment monitoring of pancreatic cancer [0.03%]
液体活检在胰腺癌诊断、预后和治疗监测中的作用不容小觑
Eleonora Rofi,Caterina Vivaldi,Marzia Del Re et al.
Eleonora Rofi et al.
Circulating tumor DNA, circulating tumor cells and tumor-related exosomes may offer new opportunities to provide insights into the biological and clinical characteristics of a neoplastic disease. They represent alternative routes for diagno...
CYP2C9*61, a rare missense variant identified in a Puerto Rican patient with low warfarin dose requirements [0.03%]
一种罕见的错义变异CYP2C9*61在需要低剂量华法林的波多黎各患者中被发现
Karla I Claudio-Campos,Pablo González-Santiago,Jessica Y Renta et al.
Karla I Claudio-Campos et al.
Warfarin continues to be the mainstay therapy for preventing thrombus formation. Although pharmacogenetic algorithms have shown higher predictability of the optimal warfarin dose and lower occurrence of bleeding episodes, they often do not ...
Case Reports
Pharmacogenomics. 2019 Jan;20(1):3-8. DOI:10.2217/pgs-2018-0143 2019
Involvement of miRNA polymorphism in mucositis development in childhood acute lymphoblastic leukemia treatment [0.03%]
儿童急性淋巴细胞白血病治疗中miRNA多态性在黏膜炎发病中的作用
Ángela Gutierrez-Camino,Maitane Umerez,Elixabet Lopez-Lopez et al.
Ángela Gutierrez-Camino et al.
Aim: Mucositis, linked to methotrexate, daunorubicin or cyclophosphamide, is a frequent childhood acute lymphoblastic leukemia (ALL) therapy side effect. miRNAs regulate the expression of pharmacokinetic/pharmacodynamic p...
Use of polygenic risk scores of nicotine metabolism in predicting smoking behaviors [0.03%]
用于预测吸烟行为的多基因风险评分与尼古丁代谢的关系
Li-Shiun Chen,Sarah M Hartz,Timothy B Baker et al.
Li-Shiun Chen et al.
Aim: This study tests whether polygenic risk scores (PRSs) for nicotine metabolism predict smoking behaviors in independent data. Materials & methods: ...
Meta-Analysis
Pharmacogenomics. 2018 Dec;19(18):1383-1394. DOI:10.2217/pgs-2018-0081 2018
Genetic polymorphism contributes to 131I radiotherapy-induced toxicities in patients with differentiated thyroid cancer [0.03%]
遗传多态性导致分化型甲状腺癌患者131I放射治疗引起的毒性反应
Jianqiu Liu,Xinyue Tang,Feng Shi et al.
Jianqiu Liu et al.
Aim: To investigate the association between SNPs in DNA damage response pathways and toxicities following 131I radiotherapy of differentiated thyroid cancer (DTC). Materials & methods: We identified 22 functional SNPs of ...