Prediction of tacrolimus dosage in the early period after heart transplantation: a population pharmacokinetic approach [0.03%]
人群药代动力学方法在心脏移植术后早期他克莫司剂量预测中的应用
Yong Han,Hong Zhou,Jie Cai et al.
Yong Han et al.
Aim: The aim of this study was to evaluate tacrolimus population pharmacokinetics and investigate factors that explain tacrolimus variability in adult heart transplant patients. ...
Integrated CYP2D6 interrogation for multiethnic copy number and tandem allele detection [0.03%]
整合的CYP2D6检测用于多民族拷贝数和串联基因型的检测
Wanqiong Qiao,Suparna Martis,Geetu Mendiratta et al.
Wanqiong Qiao et al.
Aim: To comprehensively interrogate CYP2D6 by integrating genotyping, copy number analysis and novel strategies to identify CYP2D6*36 and characterize CYP2D6 duplications. ...
Sarah Jones
Sarah Jones
Association of endothelin receptor type A rs5333 gene polymorphism with steroid response in Egyptian children with idiopathic nephrotic syndrome [0.03%]
内皮素受体基因多态性与埃及儿童原发性肾病综合征糖皮质激素反应性的相关性研究
Ghada M Ezzat,Ahlam B Ali,Nahed A Mohamed et al.
Ghada M Ezzat et al.
Aim: To investigate ENDRA rs5333 gene polymorphism distribution in idiopathic nephrotic syndrome (INS) and to analyze their association with response to steroid therapy, and biochemical markers of INS. ...
Polymorphisms in IGF2/H19 gene locus are associated with platinum-based chemotherapeutic response in Chinese patients with epithelial ovarian cancer [0.03%]
IGF2 / H19基因多态性与上皮性卵巢癌患者对以铂类为基础的化疗的反应有关
Ying Zeng,Tai-Lin Li,Hai-Bo Zhang et al.
Ying Zeng et al.
Aim: The present study aimed to assess the association between IGF2/H19 genetic variants and susceptibility to platinum-based chemotherapy in epithelial ovarian cancer (EOC). ...
Association between genetic polymorphisms and angiotensin-converting enzyme inhibitor-induced cough: a systematic review and meta-analysis [0.03%]
血管紧张素转换酶抑制剂致咳嗽的遗传因素：系统评价和Meta分析
Guangyan Mu,Qian Xiang,Shuang Zhou et al.
Guangyan Mu et al.
Aim: Genetic polymorphisms may influence the incidence of angiotensin-converting enzyme (ACE) inhibitor-induced cough. This study aims to investigate this association. ...
Meta-Analysis
Pharmacogenomics. 2019 Feb;20(3):189-212. DOI:10.2217/pgs-2018-0157 2019
Genetic variation of kinases and activation of nucleotide analog reverse transcriptase inhibitor tenofovir [0.03%]
激酶的基因变异与阿德福韦酯逆转录酶抑制作用的激活
Allyson N Hamlin,Joseph Tillotson,Namandjé N Bumpus
Allyson N Hamlin
As antiretroviral therapy has become more accessible across the world and coformulations have improved patient compliance; the morbidity and mortality of HIV/AIDS has decreased. However, there is still a substantial gap in knowledge regardi...
Validation of a clinical pharmacogenetic model to predict methotrexate nonresponse in rheumatoid arthritis patients [0.03%]
验证用于预测类风湿关节炎患者甲氨蝶呤无效的临床药物基因组模型
Frank Eektimmerman,Cornelia F Allaart,Johanna M Hazes et al.
Frank Eektimmerman et al.
Aim: To study the performance of a clinical pharmacogenetic model for the prediction of nonresponse in rheumatoid arthritis (RA) patients treated with methotrexate (MTX) in combination with other synthetic or biologic dis...
Cost-effectiveness analysis of UGT1A1*6/*28 genotyping for preventing FOLFIRI-induced severe neutropenia in Chinese colorectal cancer patients [0.03%]
UGT1A1*6/*28基因分型预防中国结直肠癌患者FOLFIRI诱导的严重中性粒细胞减少症的成本效益分析
XiaoXia Wei,JiaQin Cai,Hong Sun et al.
XiaoXia Wei et al.
Aim: To assess the cost-effectiveness of UGT1A1*6/*28 genotyping compared with no genotyping or no dose adjustment before irinotecan administration in China. ...
NF1 regulates apoptosis in ovarian cancer cells by targeting MCL1 via miR-142-5p [0.03%]
BRAF通过靶向MCL1调控卵巢癌细胞凋亡的新机制
Jiancheng Su,Shaolin Ruan,Shengkun Dai et al.
Jiancheng Su et al.
Aim: NF1 loss confers chemoresistance in multiple cancers. However, the etiology remains largely unknown. Our study aimed to scrutinize the role of NF1 in chemoresistant ovarian cancer and its underlying mechanism. ...