Patrick N Cunningham,Arlene B Chapman
Patrick N Cunningham
The interleukin-17 G-197A polymorphism is associated with cyclosporine metabolism and transplant rejection in liver transplant recipients [0.03%]
白细胞介素17 G-197A多态性与肝移植受者的环孢素代谢及移植物排斥反应相关性研究
Bo Sun,Junwei Gao,Weifeng Shi et al.
Bo Sun et al.
Aim: This study aimed to investigate the effect of and mechanism involved in the IL-17 SNP on cyclosporine metabolism and outcomes of liver transplantation (LT). Materials & methods: The IL-17 genotype, IL-17 expression, postoperative outco...
Drug-gene and drug-drug interactions associated with tramadol and codeine therapy in the INGENIOUS trial [0.03%]
INGENIOUS研究中曲马多和可待因治疗相关的药物-基因及药物-药物相互作用
Cathy R Fulton,Yong Zang,Zeruesenay Desta et al.
Cathy R Fulton et al.
Background: Tramadol and codeine are metabolized by CYP2D6 and are subject to drug-gene and drug-drug interactions. Methods: This interim analysis examined prescribing behavior and efficacy in 102 individuals prescribed tramadol or codeine ...
Clinical Trial
Pharmacogenomics. 2019 Apr;20(6):397-408. DOI:10.2217/pgs-2018-0205 2019
Evaluation of the predictive performance of Bayesian dosing for warfarin in Chinese patients [0.03%]
华法林在中国患者的贝叶斯剂量预测性能评估
Jing Dong,Guo-Hua Shi,Man Lu et al.
Jing Dong et al.
Aim: To evaluate the accuracy and predictive performance of Bayesian dosing for warfarin in Chinese patients. Materials & methods: Six ...
Genome-wide association studies of therapeutic response: addressing the complexities [0.03%]
治疗反应的全基因组关联研究：解决复杂性问题
Jennifer H Barrett
Jennifer H Barrett
Impact of pharmacogenetics and pregnancy on tenofovir and emtricitabine pharmacokinetics [0.03%]
药理遗传学和怀孕对替诺福韦和恩曲他滨药代动力学的影响
Joshua Gini,Adeniyi Olagunju,Laura Dickinson et al.
Joshua Gini et al.
Aim: Treatment and prevention of mother-to-child transmission of HIV in pregnancy utilizes tenofovir (TFV) and emtricitabine (FTC) as NRTI backbone in combination with a third agent from a different class. We hypothesized...
Population pharmacokinetic and pharmacogenetics of imatinib in Chinese patients with chronic myeloid leukemia [0.03%]
中国慢性髓性白血病患者中伊马替尼的群体药代动力学和药物基因组学研究
Qing Wang,Zhi-Ping Jiang,Er-Qian Yu et al.
Qing Wang et al.
Aim: This study aimed to establish a population pharmacokinetic (PPK) model in Chinese patients with chronic myeloid leukemia, and to quantify the effects of pharmacogenetics on pharmacokinetic parameters of imatinib. ...
Genetics of clozapine-associated neutropenia: recent advances, challenges and future perspective [0.03%]
氯氮平相关中性粒细胞减少症的遗传学：最近的研究进展、面临的挑战及未来前景
Sophie E Legge,James Tr Walters
Sophie E Legge
Clozapine is the only effective antipsychotic for treatment-resistant schizophrenia but remains widely under prescribed, at least in part due to its potential to cause agranulocytosis and neutropenia. In this article, we provide an overview...
Effects of genetic variability on rifampicin and isoniazid pharmacokinetics in South African patients with recurrent tuberculosis [0.03%]
基因变异对南非复发结核病患者利福平和异烟肼药代动力学影响的研究
Anushka Naidoo,Maxwell Chirehwa,Veron Ramsuran et al.
Anushka Naidoo et al.
Aim: We report the prevalence and effect of genetic variability on pharmacokinetic parameters of isoniazid and rifampicin. Materials & methods: ...
Association between SLCO1B1 rs4149056 and tegafur-uracil-induced hepatic dysfunction in breast cancer [0.03%]
SLCO1B1基因rs4149056多态性与乳腺癌患者卡培他滨引起肝功能异常的相关性分析
Hidenori Kamio,Toshitaka Uchiyama,Hitoshi Kanno et al.
Hidenori Kamio et al.
Aim: The aim of this study was to identify pharmacogenomic biomarkers to predict tegafur-uracil (UFT)-induced liver dysfunction. Patients & methods: A total of 68 patients, who were administered UFT, were evaluated using a two-step pharmaco...