CYP2D6 genotyping in a Korean cohort: comparative analysis with Asian, Caucasian, and African populations [0.03%]
韩国人群的细胞色素P450 2D6基因分型与亚洲、高加索和非洲后裔人群的比较分析
Tak Don Kim,Jung-Sook Kwak,Jae-Gook Shin et al.
Tak Don Kim et al.
Background: Cytochrome P450 2D6 (CYP2D6) is a highly polymorphic enzyme responsible for metabolizing approximately 20% of commonly prescribed drugs. Its genetic variability contributes to interindividual and interethnic d...
Joel E Pacyna,Suzette J Bielinski,Janet E Olson et al.
Joel E Pacyna et al.
Background: Preemptive pharmacogenomic (PGx) testing is a candidate for broad implementation because of its potential to improve medication safety and outcomes. However, little is known about how patients may process pree...
Scoping review of associations between cytochrome P450 3A4/5 single nucleotide polymorphisms and risk factors for fentanyl overdose [0.03%]
关于细胞色素P450 3A4/5单核苷酸多态性与芬太尼过量风险因素之间关联的综述研究
Dan Petrovitch,Katie P Himes,Jason J Bischof et al.
Dan Petrovitch et al.
Introduction: Fentanyl overdose is a public health crisis in the United States, as fentanyl was implicated in nearly 70% of drug overdose deaths in 2023. To provide insight into genetic factors that may influence risk of ...
How to implement pre-emptive pharmacogenetic testing in the acute hospital setting [0.03%]
急性护理环境中如何实施主动性的药物基因检测
John Henry McDermott,Ali Shoaib,Jessica Keen et al.
John Henry McDermott et al.
Your hospital has decided to introduce a pharmacogenomics program. What do you need to do to realize this ambition? In this paper, we set out the elements that should be considered, including the team and resources required to establish a s...
Assessing patient understanding of pharmacogenomic test results: a qualitative study [0.03%]
评估患者对药物基因组检测结果的理解：一项定性研究
Tom A Doyle,Samantha L Vershaw,Karen K Schmidt et al.
Tom A Doyle et al.
Aim: To examine whether patients with depression or chronic/acute pain understand the results of pharmacogenomic testing they had done as part of clinical research. ...
Exploring precision medicine by utilizing individual genetic information for the management of Alzheimer's disease [0.03%]
利用个体遗传信息指导精准医疗以管理阿尔茨海默病
Anmol Kanda,Anjna Rani,Avijit Mazumder
Anmol Kanda
Alzheimer's Disease (AD) represents a formidable challenge in neurology, characterized by progressive neurodegeneration and cognitive decline. Traditional therapeutic approaches have failed to deliver significant outcomes, underscoring the ...
Joe Chalhoub,Mélissa El Hajj,Tia Kreidy et al.
Joe Chalhoub et al.
Breast cancer is the most common malignancy in women worldwide. While personalized treatment options are obstructed by the limitations of conventional biopsy follow-up, the liquid biopsy could detect the tumor's characteristics in order to ...
A genome-wide association study of stroke risk in Asian statin users: evidence from KoGES and UK Biobank [0.03%]
一项亚洲他汀类药物使用者的卒中风险全基因组关联研究：来自韩国基因与环境协会和英国生物样本库的证据
Da Hoon Lee,Yoon-A Park,Jung Sun Kim et al.
Da Hoon Lee et al.
Background: Despite proven efficacy of statins in stroke prevention, genetic factors may influence individual stroke risk among statin users. With increasing precision medicine approaches and growing evidence of populatio...
Pharmacogenomic variants affecting efficacy and safety of medicines acting on central nervous system among Sri Lankans [0.03%]
斯里兰卡人群中枢神经系统药物效应和安全性的药理遗传变异的影响
Priyanga Ranasinghe,Charindie Peiris,Hajanthy Jeyapragasam et al.
Priyanga Ranasinghe et al.
Background: Ensuring the efficacy and safety of medicines acting on the central nervous system (CNS) remains a challenge due to their complex pharmacokinetics and inter-individual variability in response. We describe the ...
Lakshmi Aravindan,Sanjana Velu,Inesh Sivam et al.
Lakshmi Aravindan et al.
Buprenorphine, a semi-synthetic opioid, is used to treat Opioid Use Disorder (OUD) and as an analgesic. Buprenorphine's benefits over other opioids include longer duration of action, lower abuse potential, and a ceiling effect to serious ad...