Pharmacogenetics of graft-versus-host disease: a path to personalized medicine [0.03%]
移植抗宿主病的药物基因组学——通向个性化医疗之路
Piotr Łacina,Jagoda Siemaszko,Katarzyna Bogunia-Kubik
Piotr Łacina
Graft-versus-host disease (GvHD) remains a significant complication of allogeneic hematopoietic stem cell transplantation (HSCT), contributing to increased morbidity and mortality. Thus, continuous development of novel prophylactic and ther...
Evidence level for pharmacogenetic testing in antidepressant treatment: a systematic review [0.03%]
抗抑郁药治疗药物基因检测的证据等级：系统性综述
Emytis Tavakoli,Leen Magarbeh,Samar Elsheikh et al.
Emytis Tavakoli et al.
Rationale: Preemptive pharmacogenetic (PGx) testing offers a promising approach to personalized antidepressant treatment by identifying genetic variations influencing drug metabolism. By focusing on CYP2D6 and CYP2C19 gen...
Predicting nifedipine responses in preterm labor: a risk score incorporating ABCG2 polymorphisms and clinical factors [0.03%]
一项结合ABCG2多态性和临床因素预测早产的硝地平反应的评分系统
Jungsun Kim,Ji Min Han,Jeong Yee et al.
Jungsun Kim et al.
Background: Nifedipine, a substrate of ATP-binding cassette superfamily G member 2 (ABCG2), is a tocolytic agent. This study aimed to construct a scoring system by exploring the association between ABCG2 polymorphisms and...
From bench to bedside: a spotlight on pharmacogenomics at Nemours Children's Health [0.03%]
从实验室到病床旁：了解纳尔逊儿童健康中心的药物基因组学
Kelsey J Cook,Nathan D Seligson,Benjamin Q Duong et al.
Kelsey J Cook et al.
Nemours Children's Health (NCH) is a large, multi-state pediatric health system in the United States with hospitals and outpatient locations across Delaware, New Jersey, Pennsylvania, and Florida. NCH has maintained consistent effort in pha...
Impact of ABCB1 gene polymorphism on clopidogrel plasma concentration and cardiovascular events in post-PCI patients [0.03%]
ABCB1基因多态性对PCI术后患者氯吡格雷血药浓度及心血管事件的影响
Abdur Razaq,Waheed Iqbal,Syed Tahir Shah et al.
Abdur Razaq et al.
Aim: This study investigated the impact of ABCB1 gene polymorphisms on clopidogrel absorption and therapeutic response by analyzing plasma levels of the clopidogrel carboxylic acid metabolite (CAM), and cardiovascular eve...
Variation in the ABC transporter genes and association with clinical outcomes in colorectal cancer: a brief review [0.03%]
结直肠癌中ABC转运蛋白基因多态性与临床结局的关联：综述
Zari Salahud Din,Maryam Saqib,Sehrish Zafar et al.
Zari Salahud Din et al.
Colorectal cancer is one of the most prevalent cancers worldwide. We have thus focused on studies on the association of genetic polymorphisms with treatment response and adverse effects in colorectal cancer patients. This review highlights ...
Genetic polymorphisms and adverse reactions to antituberculosis therapy [0.03%]
结核病治疗的药物不良反应与遗传多态性的关系研究进展
Hannah M Gunter,Phuti Choshi,Tafadzwa Chimbetete et al.
Hannah M Gunter et al.
Tuberculosis is the leading cause of death from a single infectious agent globally, with the highest burden in low-and middle-income countries. Successful treatment requires prolonged administration of multiple drugs. The increasing threat ...
Genomewide association analysis on green tea chemoprevention of colorectal adenoma: the importance of SLCO1A2 variants [0.03%]
基于全基因组关联分析的绿茶预防结直肠腺瘤作用研究：SLCO1A2变异的重要性
J Stingl,C Scholl,M Steffens et al.
J Stingl et al.
Background: Green tea extract was tested for the secondary prevention of colorectal adenoma in the placebo-controlled MIRACLE trial. Genome-wide screening on adenoma recurrence was performed in n = 550 participants 3 year...
Hypertension precision medicine: the promise and pitfalls of pharmacogenomics [0.03%]
高血压的精准医疗：药物基因组学的应用前景与潜在问题
Nhu Ngoc Le,Iain Frater,Stefanie Lip et al.
Nhu Ngoc Le et al.
Pharmacogenomics (PGx) has the potential to revolutionize hypertension management by tailoring antihypertensive therapy based on genetic profiles. Despite significant advances in genomic research, the clinical translation of PGx in hyperten...
Machine learning models for pharmacogenomic variant effect predictions - recent developments and future frontiers [0.03%]
药理遗传学变异效应预测的机器学习模型——近期进展与未来前景
Roman Tremmel,Antoine Honore,Yoomi Park et al.
Roman Tremmel et al.
Pharmacogenomic variations in genes involved in drug disposition and in drug targets is a major determinant of inter-individual differences in drug response and toxicity. While the effects of common variants are well established, millions o...