CYP2C19 genotype, physician prescribing pattern, and risk for long QT on serotonin selective reuptake inhibitors [0.03%]
临床医师处方习惯、CYP2C19基因型与选择性5-羟色胺再摄取抑制剂所致长QT综合征风险之间的关联
Natasha Petry,Roxana Lupu,Ahmed Gohar et al.
Natasha Petry et al.
Aim: To examine the impact of CYP2C19 genotype on selective serotonin reuptake inhibitor (SSRI) prescribing patterns. Patients & methods: Observational cohort containing 507 unique individuals receiving an SSRI prescription with CYP2C19 gen...
Observational Study
Pharmacogenomics. 2019 Apr;20(5):343-351. DOI:10.2217/pgs-2018-0156 2019
Anuradha Thiagarajan,N Gopalakrishna Iyer
Anuradha Thiagarajan
Radiotherapy is an important modality in the management of squamous cell cancers with 50% of patients receiving radiotherapy at some point. Despite technological advances, the risk of severe toxicity in a proportion of radiosensitive patien...
Perplexed by PGx? Exploring the impact of pharmacogenomic results on medical management, disclosures and patient behavior [0.03%]
对PGx困惑？探索药理基因组结果对医疗管理、披露和患者行为的影响
Larissa Waldman,Cheryl Shuman,Iris Cohn et al.
Larissa Waldman et al.
Pharmacogenomic (PGx) tests represent significant advances in precision medicine. Our aim was to explore perceptions following the return of PGx results, medication management, and disclosure to providers. We surveyed clients who had PGx te...
Identification of a single-nucleotide polymorphism within CDH2 gene associated with bone morbidity in childhood acute lymphoblastic leukemia survivors [0.03%]
CDH2基因单核苷酸多态性与儿童急性淋巴细胞白血病存活者骨病变的相关性研究
Michelle Aaron,Geneviève Nadeau,Erika Ouimet-Grennan et al.
Michelle Aaron et al.
Aim: To identify genetic markers associated with late treatment-related skeletal morbidity in survivors of childhood acute lymphoblastic leukemia (ALL). Patients & methods: To this end, we measured the association between reduction in bone ...
Impact of CYP3A5 phenotype on tacrolimus concentrations after sublingual and oral administration in lung transplant [0.03%]
CYP3A5基因型对肺移植后口服和舌下给药他克莫司浓度的影响
Amy L Pasternak,Kelley M Kidwell,Jacqueline M Dempsey et al.
Amy L Pasternak et al.
Aim: This study evaluated the impact of CYP3A5 genotype and other patient characteristics on sublingual (SL) tacrolimus exposure and compared the relationship with oral administration. Patients & methods: Tacrolimus concentrations were retr...
VMAT2 gene (SLC18A2) variants associated with a greater risk for developing opioid dependence [0.03%]
与阿片类物质依赖发病风险增加相关的VMAT2基因(SLC18A2)变异体
Matthew Randesi,Wim van den Brink,Orna Levran et al.
Matthew Randesi et al.
Aim: To determine if selected serotonergic and noradrenergic gene variants are associated with heroin addiction. Subjects & methods: A total of 126 variants in 19 genes in subjects with Dutch European ancestry from The Netherlands. Subjects...
A systematic review of genome-wide association studies of antipsychotic response [0.03%]
抗精神病药物反应的全基因组关联研究系统评价
Josiah D Allen,Jeffrey R Bishop
Josiah D Allen
Clinical symptom response to antipsychotic medications is highly variable. Genome-wide association studies (GWAS) provide a 'hypothesis-free' method of interrogating the genome for biomarkers of antipsychotic response. We performed a system...
Contemporary pharmacogenetic assays in view of the PharmGKB database [0.03%]
参考PharmGKB数据库的当代药物基因组检测方法
Laurentijn Tilleman,Jana Weymaere,Björn Heindryckx et al.
Laurentijn Tilleman et al.
Aim: Six modern PGx assays were compared with the Pharmacogenomics Knowledge Base (PharmGKB) to determine the proportion of the currently known PGx genotypes that are assessed by these assays. ...
GLP1R variant is associated with response to exenatide in overweight Chinese Type 2 diabetes patients [0.03%]
中国肥胖型2型糖尿病患者注射艾塞那肽疗效与GLP-1受体变异相关性研究
Mingjun Yu,Kaiyu Wang,Haiming Liu et al.
Mingjun Yu et al.
Aim: Exenatide is a glucagon-like peptide 1receptor agonist, having both glycemic and weight loss benefits. Given that previous pharmacogenetic studies reported inconsistent evidence of association between variants in the...
Differential long noncoding RNAs expression in cancer-associated fibroblasts of non-small-cell lung cancer [0.03%]
非小细胞肺癌相关癌旁成纤维细胞差异性长链非编码RNA表达谱分析
Cuifang Teng,Guolin Huang,Yanmei Luo et al.
Cuifang Teng et al.
Aim: The aim of this study was to investigate the role of long noncoding RNAs (lncRNAs) profiles in cancer-associated fibroblasts (CAFs) during non-small-cell lung cancer (NSCLC) progression. ...