The impact of HER2 overexpression on the miRNA and circRNA transcriptomes in two breast cell lines and their vesicles [0.03%]
HER2过度表达对两种乳腺癌细胞系及其囊泡的miRNA和circRNA转录组的影响
Maria Galli de Amorim,Gabriela Branco,Renan Valieris et al.
Maria Galli de Amorim et al.
HER2 upregulation is related with poor outcome in many tumor types. Whereas anti-HER2 treatment is the standard approach as adjuvant therapy in HER2-overexpressing breast cancer, the frequent relapses reinforce the need for alternative trea...
Systems pharmacogenomics - gene, disease, drug and placebo interactions: a case study in COMT [0.03%]
系统药理基因组学-基因、疾病、药物和安慰剂的相互作用：COMT的一个案例研究
Kathryn T Hall,Joseph Loscalzo,Ted J Kaptchuk
Kathryn T Hall
Disease, drugs and the placebos used as comparators are inextricably linked in the methodology of the double-blind, randomized controlled trial. Nonetheless, pharmacogenomics, the study of how individuals respond to drugs based on genetic s...
Genetics and adverse events with irinotecan treatment: what do we know? [0.03%]
伊立替康治疗过程中的不良事件与遗传学因素：我们了解多少？
David Páez
David Páez
Association between VEGFA gene polymorphisms and bleeding complications in patients maintaining therapeutic international normalized ratio [0.03%]
VEGFA基因多态性与维持治疗国际标准化比值患者的出血并发症的相关性研究
Jeong Yee,Woorim Kim,Byung Chul Chang et al.
Jeong Yee et al.
Aim: This study was designed to identify the possible effects of VEGFA polymorphisms on the occurrence of bleeding complications in patients with mechanical heart valves who have achieved therapeutic international normalized ratio (INR). Ma...
Processes and barriers to implementation of point-of-care genotype-guided dosing of warfarin into UK outpatient anticoagulation clinics [0.03%]
在英国门诊抗凝诊所中，指导华法林用药的基因检测实施过程及遇到的障碍
Gail Fitzgerald,Clare Prince,Jennifer Downing et al.
Gail Fitzgerald et al.
Association between ABCB1 C3435T polymorphism and methotrexate treatment outcomes in rheumatoid arthritis patients: a meta-analysis [0.03%]
ABCB1 C3435T多态性与类风湿关节炎患者甲氨蝶呤治疗效果的关联：一项meta分析
Xiao He,Mingfang Sun,Shenju Liang et al.
Xiao He et al.
Aim: This study was conducted to investigate the relationship between ABCB1 gene C3435T polymorphism and methotrexate treatment outcomes in rheumatoid arthritis patients. Methods: Seven electronic databases (PubMed, EMBASE, Web of Science, ...
Ida Kappel Buhl,Peter Buhl Jensen,Anna Sofie Kappel Buhl et al.
Ida Kappel Buhl et al.
Extremely low therapeutic doses of acenocoumarol in a patient with CYP2C9*3/*3 and VKORC1-1639A/A genotype [0.03%]
一种华法林低剂量治疗病例的药理学分析及遗传学研究
Antigoni Chaidaroglou,Theoni Kanellopoulou,George Panopoulos et al.
Antigoni Chaidaroglou et al.
Vitamin-K antagonists (VKAs) have remained the mainstay of oral anticoagulant therapy for the treatment and prevention of thromboembolism. The management of treatment with VKAs is challenging due to their narrow therapeutic index and the wi...
Implementing pharmacogenetic testing in rural primary care practices: a pilot feasibility study [0.03%]
农村初级保健机构实施药物基因组检测的可行性研究
Lynn G Dressler,Gillian C Bell,Pearl M Abernathy et al.
Lynn G Dressler et al.
Aim: Assess feasibility and perspectives of pharmacogenetic testing/PGx in rural, primary care physician (PCP) practices when PCPs are trained to interpret/apply results and testing costs are covered. Methods: Participants included PCPs who...
Observational Study
Pharmacogenomics. 2019 Apr;20(6):433-446. DOI:10.2217/pgs-2018-0200 2019
Cell-free DNA diagnostics: current and emerging applications in oncology [0.03%]
无细胞DNA诊断技术在肿瘤学中的应用：现状与前景
Penn Muluhngwi,Roland Valdes Jr,Rafael Fernandez-Botran et al.
Penn Muluhngwi et al.
Liquid biopsy is a noninvasive dynamic approach for monitoring disease over time. It offers advantages including limited risks of blood sampling, opportunity for more frequent sampling, lower costs and theoretically non-biased sampling comp...