Effects of SLCO1B1 polymorphisms on plasma estrogen concentrations in women with breast cancer receiving aromatase inhibitors exemestane and letrozole [0.03%]
SLCO1B1多态性对乳腺癌患者服用阿那曲唑和依西美坦后血浆雌激素浓度的影响
Jacqueline M Dempsey,Kelley M Kidwell,Christina L Gersch et al.
Jacqueline M Dempsey et al.
Aim: This study tested for associations between SLCO1B1 polymorphisms and circulating estrogen levels in women with breast cancer treated with letrozole or exemestane. Patients & methods: Postmenopausal women with hormone-receptor positive ...
Randomized Controlled Trial
Pharmacogenomics. 2019 Jun;20(8):571-580. DOI:10.2217/pgs-2019-0020 2019
Big data in pharmacogenomics: current applications, perspectives and pitfalls [0.03%]
药物基因组学中的大数据：当前应用、展望和潜在问题
Claire-Cécile Barrot,Jean-Baptiste Woillard,Nicolas Picard
Claire-Cécile Barrot
The efficiency of new generation sequencing methods and the reduction of their cost has led pharmacogenomics to gradually supplant pharmacogenetics, leading to new applications in personalized medicine along with new perspectives in drug de...
The importance and challenges of developing a pharmacogenetics test for hypertension [0.03%]
高血压药物基因组检测的研发之重要性及其挑战
Eric M Snyder,Eli F Kelley,Ryan Sprissler et al.
Eric M Snyder et al.
NR3C1, ABCB1, TNF and CYP2C19 polymorphisms association with the response to the treatment of erythema nodosum leprosum [0.03%]
NR3C1、ABCB1、TNF和CYP2C19多态性与结节性肢皮病治疗反应相关的关联研究
Perpétua do Socorro Silva Costa,Thayne Woycinck Kowalski,Lucas Rosa Fraga et al.
Perpétua do Socorro Silva Costa et al.
Aim: To evaluate the effects of gene polymorphisms in the treatment of erythema nodosum leprosum with prednisone/thalidomide. Patients & methods: A total of 152 patients from different regions of Brazil were included. Generalized estimating...
Vid Mlakar,Janja Marc,Vangelis G Manolopoulos et al.
Vid Mlakar et al.
In September 2018, the European Society of Pharmacogenomics and Personalised Therapy (ESPT), with the support of the Swiss Personalized Health Network (SPHN), organized its 4th biennial summer school, entitled 'Precision Medicine and Person...
Genomic profiling and predicting treatment response in acute myeloid leukemia [0.03%]
急性髓系白血病的基因组分析及预测治疗方法的效果
Alessandro Isidori,Federica Loscocco,Antonio Curti et al.
Alessandro Isidori et al.
Between a rock and a hard place: a high-risk patient with resistance to multiple P2Y12 antagonists [0.03%]
进退维谷：对多种P2Y12受体拮抗剂耐药的高危患者病例
Brittney H Davis,Chrisly Dillon,Anping Cai et al.
Brittney H Davis et al.
Impaired response to P2Y12 receptor antagonists, such as clopidogrel and prasugrel, can have devastating consequences for patients that require prolonged or indefinite therapy with these agents, including those with a left ventricular assis...
Case Reports
Pharmacogenomics. 2019 May;20(7):475-481. DOI:10.2217/pgs-2018-0201 2019
The impact of CYP2C19 and CYP4F2 variants and clinical factors on treatment outcomes during antiplatelet therapy [0.03%]
临床因素和基因变异对接受抗血小板治疗患者预后的影响研究——与CYP2C19和CYP4F2相关
Vacis Tatarunas,Nora Kupstyte-Kristapone,Rita Norvilaite et al.
Vacis Tatarunas et al.
Aim: The aim of this study was to determine the impact of genetic and nongenetic factors on treatment outcomes in patients receiving dual antiplatelet therapy after percutaneous coronary intervention and stent implantation. Materials & meth...
The GNAS SNP c.393C>T (rs7121) as a marker for disease progression and survival in cancer [0.03%]
GNAS基因多态性c.393C>T（rs7121）与肿瘤发生发展及预后的相关性研究
Birte Möhlendick,Kurt W Schmid,Winfried Siffert
Birte Möhlendick
G-protein receptor signaling plays a key role in multiple signal transduction pathways. Aberrant activity of the stimulatory Gsα subunit has been frequently associated with cancer. GNAS sequence alterations and conformational changes of Gs...
Influence of CYP3A5 and SLCO1B1 polymorphisms on atazanavir/r concentrations in Thai HIV-infected patients [0.03%]
CYP3A5和SLCO1B1基因多态性对泰国艾滋病患者阿扎那韦血药浓度的影响
Noppaket Singkham,Anchalee Avihingsanon,Narukjaporn Thammajaruk et al.
Noppaket Singkham et al.
Aim: To evaluate the influence of genetic polymorphisms on plasma trough concentrations of atazanavir (ATV) and ritonavir (RTV). Patients & methods: The concentration-to-dose ratios were compared between different genotype groups of CYP3A5,...